Genomic imbalances in urothelial cancer: Intratumor heterogeneity versus multifocality

Diagnostic Molecular Pathology

Volumn 17, Issue 3, 2008, Pages 134-140

  Prat, Esther ^a   Del Rey, Javier ^a   Camps, Jordi ^a   Ponsa, Immaculada ^a   Lloreta, Josep ^a   Egozcue, Josep ^a   Gelabert, Antoni ^a   Campillo, Mercedes ^a   Miro, Rosa ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Chromosome imbalances; Heterogeneity; Multifocal; Synchronous; Urothelial cancer

Indexed keywords

AGED; ARTICLE; BLADDER TUMOR; CHROMOSOMAL INSTABILITY; CHROMOSOME 17Q; CHROMOSOME 1Q; CHROMOSOME 2P; CHROMOSOME 4Q; CHROMOSOME LOSS; CHROMOSOME NUMBER; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CYTOGENETICS; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; CHROMOSOME ABERRATION; CLUSTER ANALYSIS; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; NUCLEIC ACID HYBRIDIZATION; PATHOLOGY; TRANSITIONAL CELL CARCINOMA;

AGED; AGED, 80 AND OVER; CARCINOMA, TRANSITIONAL CELL; CHROMOSOME ABERRATIONS; CLUSTER ANALYSIS; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; NUCLEIC ACID HYBRIDIZATION; URINARY BLADDER NEOPLASMS;

EID: 54049107373     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/PDM.0b013e31815ce4e6     Document Type: Article

References (28)

1. Yao A, Rubin H. A critical test of the role of population density in producing transformation. Proc Natl Acad Sci USA. 1994;91: 7712-7716.
2. Sidransky D, Frost P, Von Eschenbach A, et al. Clonal origin bladder cancer. N Engl J Med. 1992;326:737-740.
3. Harris AL, Neal DE. Bladder cancer - field versus clonal origin. N Engl J Med. 1992;326:759-761.
4. Li M, Cannizzaro LA. Identical clonal origin of synchronous and metachronous low-grade, noninvasive papillary transitional cell carcinomas of the urinary tract. Hum Pathol. 1999;30:1197-1200.
5. Takahashi T, Habuchi T, Kakehi Y, et al. Clonal and chronological genetic analysis of multifocal cancers of the bladder and upper urinary tract. Cancer Res. 1998;58:5835-5841.
6. Louhelainen J, Wijkstrom H, Hemminki K. Allelic losses demonstrate monoclonality of multifocal bladder tumors. Int J Cancer. 2000;87:522-527.
7. Dalbagni G, Ren ZP, Herr H, et al. Genetic alterations in tp53 in recurrent urothelial cancer: a longitudinal study. Clin Cancer Res. 2001;7:2797-2801.
8. van Tilborg AA, de Vries A, de Bont M, et al. Molecular evolution of multiple recurrent cancers of the bladder. Hum Mol Genet. 2000;9:2973-2980.
9. Fadl-Elmula I, Gorunova L, Mandahl N, et al. Cytogenetic monoclonality in multifocal uroepithelial carcinomas: evidence of intraluminal tumour seeding. Br J Cancer. 1999;81:6-12.
10. Simon R, Eltze E, Schafer KL, et al. Cytogenetic analysis of multifocal bladder cancer supports a monoclonal origin and intraepithelial spread of tumor cells. Cancer Res. 2001;61:355-362.
11. Denzinger S, Mohren K, Knuechel R, et al. Improved clonality analysis of multifocal bladder tumors by combination of histopathologic organ mapping, loss of heterozygosity, fluorescence in situ hybridization, and p53 analyses. Hum Pathol. 2006;37:143-151.
12. Hafner C, Knuechel R, Stoehr R, et al. Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies. Int J Cancer. 2002;101:1-6.
13. Duggan BJ, Gray SB, McKnight JJ, et al. Oligoclonality in bladder cancer: the implication for molecular therapies. J Urol. 2004; 171:419-425.
14. Takahashi T, Kakehi Y, Mitsumori K, et al. Distinct microsatellite alterations in upper urinary tract tumors and subsequent bladder tumors. J Urol. 2001;165:672-677.
15. Hartmann A, Schlake G, Zaak D, et al. Occurrence of chromosome 9 and p53 alterations in multifocal dysplasia and carcinoma in situ of human urinary bladder. Cancer Res. 2002;62:809-818.
16. Yamamoto S, Romanenko A, Wei M, et al. Specific p53 gene mutations in urinary bladder epithelium after the Chernobyl accident. Cancer Res. 1999;59:3606-3609.
17. Cheng L, Gu J, Ulbright TM, et al. Precise microdissection of human bladder carcinomas reveals divergent tumor subclones in the same tumor. Cancer. 2002;94:104-110.
18. Cheng L, Jones TD, McCarthy RP, et al. Molecular genetic evidence for a common clonal origin of urinary bladder small cell carcinoma and coexisting urothelial carcinoma. Am J Pathol. 2005;166: 1533-1539.
19. Mostofi FK, Sorbin LH, Torloni H. Histological Typing of Urinary Bladder Tumors. International Histological Classification of Tumors. Geneva, Switzerland: World Health Organization; 1973.
20. Harmer MH. Union Internationale contre le Cancer. TNM Classification of Malignant Tumors. 3rd ed. Berlin: Springer Verlag; 1978.
21. Sambrook J, Fritch E, Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbour: Cold Spring Harbour Laboratory Press; 1989.
22. Prat E, Bernues M, Caballin MR, et al. Detection of chromosomal imbalances in papillary bladder tumors by comparative genomic hybridization. Urology. 2001;57:986-992.
23. Kuukasjarvi T, Karhu R, Tanner M, et al. Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer. Cancer Res. 1997;57:1597-1604.
24. Pasca di Magliano M, Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer. 2003;3: 903-911.
25. Xiaoli Ma TS, Zhang Y, Zhang X, et al. Hedgehog signaling is activated in subsets of esophageal cancers. Int J Cancer. 2006;118: 139-148.
26. Simon R, Richter J, Wagner U, et al. High-throughput tissue microarray analysis of 3p25 (RAF1) and 8p12 (FGFR1) copy number alterations in urinary bladder cancer. Cancer Res. 2001; 61:4514-4519.
27. Letessier A, Sircoulomb F, Ginestier C, et al. Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers. BMC Cancer. 2006; 6:245.
28. Gisselsson D, Jonson T, Petersen A, et al. Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc Natl Acad Sci USA. 2001;98:12683-12688.