Functional computed tomographic quantification of angiogenesis in rabbit VX2 soft-tissue tumor before and after interventional therapy

Journal of Computer Assisted Tomography

Volumn 32, Issue 5, 2008, Pages 697-705

  Zhang, Jingfeng ^a   Wang, Renfa ^b   Lou, Haiyan ^a   Zou, Yu ^a   Zhang, Minming ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Interventional; Neoplasm; Neovascularization; Pathological; Perfusion; Radiology; Tomography; X ray computed

Indexed keywords

BLOOD; BLOOD VESSELS; CONTRAST MEDIA; ENDOTHELIAL CELLS; HEMODYNAMICS; RADIOLOGY; TUMORS;

BLOOD FLOW; BLOOD VOLUMES; INTERVENTIONAL; MEAN TRANSIT TIME; NEO-VASCULARIZATION; NEOPLASM; PATHOLOGICAL; PERFUSION; VX2 TUMOR; X-RAY COMPUTED;

COMPUTERIZED TOMOGRAPHY;

IOPROMIDE; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL EMBOLISM; BLOOD FLOW; BLOOD VESSEL PERMEABILITY; BLOOD VOLUME; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; MALE; MICROVASCULATURE; MONITORING; MULTIDETECTOR COMPUTED TOMOGRAPHY; MUSCLE; NONHUMAN; OPTICAL DENSITY; PRIORITY JOURNAL; RABBIT; SOFT TISSUE TUMOR; THIGH; ANIMAL; COMPUTER ASSISTED TOMOGRAPHY; IMMUNOHISTOCHEMISTRY; METHODOLOGY; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PATHOPHYSIOLOGY; RADIOGRAPHY;

ANIMALS; EMBOLIZATION, THERAPEUTIC; IMMUNOHISTOCHEMISTRY; NEOVASCULARIZATION, PATHOLOGIC; RABBITS; SOFT TISSUE NEOPLASMS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 54049103972     PISSN: 03638715     EISSN: None     Source Type: Journal    
DOI: 10.1097/RCT.0b013e31815b7dcf     Document Type: Article

References (19)

1. Folkman J. The role of angiogenesis in tumor growth. Semin Cancer Biol. 1992;3:65-71.
2. Nugent LJ, Jain RK. Extravascular diffusion in normal and neoplastic tissues. Cancer Res. 1984;44:238-244.
3. Miles KA. Functional computed tomography in oncology [review]. Eur J Cancer. 2002;38:2079-2084.
4. Miles KA. Perfusion CT for the assessment of tumour vascularity: which protocol? Br J Radiol. 2003;76(S1):36-42.
5. Pollard RE, Garcia TC, Stieger SM, et al. Quantitative evaluation of perfusion and permeability of peripheral tumors using contrast-enhanced computed tomography. Invest Radiol. 2004;39:340-349.
6. Weidner N. Tumor vascularity and proliferation: clear evidence of a close relationship. J Pathol. 1999;189:297-299.
7. Lee TY. Functional CT: physiological models. Trends Biotechnol. 2002;20(Sl):S3-S10.
8. Miles KA, Griffiths MR. Perfusion CT: a worthwhile enhancement? Br J Radiol. 2003;76:220-231.
9. Cenic A, Nabavi DG, Craen RA, et al. Dynamic CT measurement of cerebral blood flow: a validation study. AJNR Am J Neuroradiol. 1999;20:63-73.
10. Cenic A, Nabavi DG, Craen RA, et al. A CT method to measure hemodynamics in brain tumors: validation and application of cerebral blood flow maps. AJNR, Am J Neuroradiol. 2000;21:462-470.
11. Eastwood JD, Lev MH, Azhari T, et al. CT perfusion scanning with deconvolution analysis: pilot study in patients with acute middle cerebral artery stroke. Radiology. 2002;222:227-236.
12. Purdie TG, Henderson E, Lee TY. Functional CT imaging of angiogenesis in rabbit VX2 soft-tissue tumor. Phys Med Biol. 2001;46:3161-3175.
13. Miles KA. Functional CT imaging in oncology. Eur Radiol. 2003;13(S5): 134-138.
14. Zhang J, Wang R, Wang M, et al. Experimental study of multi-slice spiral CT perfusion imaging in VX2 soft-tissue tumor of rabbits. J Huazhong Univ Sci Technol Med Sci. 2006;26(3):341-343.
15. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9:669-676.
16. Liao XF, Yi JL, Li XR, et al. Angiogenesis in rabbit hepatic tumor after transcatheter arterial embolization. World J Gastroenterol. 2004;10: 1885-1889.
17. Dvorak HF, Brown LF, Detmar M, et al. Vascular permeability factor/ vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol. 1995;146:1029-1039.
18. Jain RK. Normalizing tumor vasculature with antiangiogenic therapy: a new paradigm for combination therapy. Nat Med. 2001;7:987-989.
19. Sahani DV, Kalva SP, Hamberg LM, et al. Assessing tumor perfusion and treatment response in rectal cancer with multisection CT: initial observations. Radiology. 2005;234:785-792.