The association between SCN5A, KCNQ1 and KCNE1 gene polymorphisms and complex ventricular arrhythmias in survivors of myocardial infarction

Kardiologia Polska

Volumn 66, Issue 8, 2008, Pages 845-853

  Olszak Waśkiewicz, Marlena ^a,d   Kubik, Leszek ^b   Dziuk, Mirosław ^b   Sidło, Ewa ^b   Kucharczyk, Krzysztof ^c   Kaczanowski, Radosław ^c  

^a LUX MED Medical Clinic   (Poland)

^b MILITARY INSTITUTE OF MEDICINE   (Poland)

^c Kucharczyk Techniki Elektroforetyczne Sp z oo   (Poland)

^d Centrum Medyczne Lux Med SA   (Poland)

Author keywords

Myocardial infarction; QT interval; Single nucleotide polymorphisms; Ventricular arrhythmia

Indexed keywords

POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; PROTEIN SCN5A; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HEART ARREST; HEART INFARCTION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; HOLTER MONITORING; HUMAN; MAJOR CLINICAL STUDY; MALE; PHYSICAL EXAMINATION; QT DISPERSION; QT INTERVAL; QT PROLONGATION; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVOR;

EID: 54049092446     PISSN: 00229032     EISSN: 00229032     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Strzelecki Z. (ed.). Wybrane problemy zdrowotne ludności. Choroby układu kra̧żenia w Polsce. Sytuacja epidemiologiczna. Raport 2005-2006. Sytuacja demograficzna Polski. Rza̧dowa Rada Ludnościowa. Warszawa 2006.
2. Priori SG, Napolitano C, Humphries S, et al. Zagadnienia genetyczne w chorobach układu kra̧żenia. In: Camm AJ, Lüscher TF, Serruys PW (ed.). Choroby serca i naczyń. Podrȩcznik Europejskiego Towarzystwa Kardiologicznego. Termedia 2006; 197-224.
3. Splawski I, Timothy KW, Tateyama M, et al. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science 2002; 297: 1333-6.
4. Wang Q, Curran ME, Splawski I, et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations causa cardiac arrhythmias. Nat Genet 1996; 12: 17-23.
5. Larsen LA, Andersen PS, Kanters JK, et al. A single stand conformation polymorphism/heteroduplex (SSCP/HD) method for detection of mutations in 15 exons of the KVLQT1 gene, associated with long QT syndrome. Clin Chim Acta 1999; 280: 113-25.
6. Priori SG, Aliot E, Blømstrom-Lundqvist C, et al. Task force on sudden cardiac death of the European Society of Cardiology. Eur Hart J 2001; 22: 1374-450.
7. Kaczanowski R, Trzeciak L, Kucharczyk K. Multitemperature single-strand conformation polymorphism. Electrophoresis 2001; 22: 3539-45.
8. Sesti F, Abbott GW, Wei J, et al. A common polymorphism associated with antibiotic - induced cardiac arrhythmia. Proc Natl Acad Sci USA 2000; 97: 10613-8.
9. Kubota T, Shimizu W, Kamakura S, et al. Hypokalemia-induced long QT syndrome with an underlying novel missense mutation in S4-S5 linker of KCNQ1. J Cardiovasc Electrophysiol 2000; 11: 1048-54.
10. Napolitano C, Schwartz PJ, Brown AM, et al. Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias. J Cardiovasc Elektrophysiol 2000; 11: 691-6.
11. Hu D, Viskin S, Oliva A, et al. Novel mutation in the SCN5A gene associated with arrhythmic storm development during acute myocardial infarction. Heart Rhythm 2007; 4: 1072-80.
12. Gouas L, Nicaud V, Berthet M, et al. Association of KCNQ1, KCNE1, KCNH2 and SCN5A polymorphisms with QTc interval length in healthy population. Eur J Hum Genet 2005; 13: 1213-22.
13. Yang P, Kanki H, Drolet B, et al. Alleli variants in Long-QT disease genes in patients with drug-associated torsades de pointes. Circulation 2002; 105: 1943-8.
14. Akyol M, Jalilzadeh S, Sinner MF, et al. The common non-synonymous variant G38S of the KCNE1-(minK) gene is not associated to QT interval in Central European Caucasians: results from the KORA study. Eur Heart J 2007; 28: 305-9.
15. Higham PD, Campbell RW. QT dispersion. Br Heart J 1994; 71: 508-10.
16. Zabel M, Klingenheben T, Franz MR, et al. Assessment of QT dispersion for prediction of mortality or arrhythmic events after myocardial infarction: results of a prospective, long-term follow-up study. Circulation 1998; 97: 2543-50.
17. Zhang L, Vincent GM, Baralle M, et al. An intronic mutation causes long QT syndrome. J Am Coll Cardiol 2004; 44: 1283-91.
18. Baralle D, Baralle M. Splicing in action: assessing disease causing sequence changes. J Med Genet 2005; 42: 737-48.
19. Buratti E, Baralle M, Baralle FE. Defectiva splicing, disease and therapy: searching for master checkpoints in exon definition. Nucleic Acids Res 2006; 34: 3494-510.