Combined expression of the non-receptor protein tyrosine kinases FAK and Src in primary colorectal cancer is associated with tumor recurrence and metastasis formation

European Journal of Surgical Oncology

Volumn 34, Issue 11, 2008, Pages 1253-1261

  de Heer, P ^a   Koudijs, M M ^a   van de Velde, C J H ^a   Aalbers, R I J M ^a   Tollenaar, R A E M ^a   Putter, H ^a   Morreau, J ^a   van de Water, B ^b   Kuppen, P J K ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Colorectal cancer; Focal adhesion kinase (FAK); Paxillin; Prognosis; Src

Indexed keywords

FOCAL ADHESION KINASE; PAXILLIN; SRC PROTEIN; STEROID RECEPTOR COACTIVATOR 1; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; COLORECTAL CANCER; DISEASE COURSE; HUMAN; HUMAN TISSUE; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR RECURRENCE;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; COLORECTAL NEOPLASMS; FEMALE; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; INFANT, NEWBORN; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PAXILLIN; PROGNOSIS; SRC-FAMILY KINASES; TUMOR MARKERS, BIOLOGICAL;

EID: 54049091130     PISSN: 07487983     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejso.2008.05.003     Document Type: Article

References (25)

1. Webb D.J., Parsons J.T., and Horwitz A.F. Adhesion assembly, disassembly and turnover in migrating cells - over and over and over again. Nat Cell Biol 4 (2002) E97-E100
2. Mitra S.K., Hanson D.A., and Schlaepfer D.D. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 6 (2005) 56-68
3. Schlaepfer D.D., Hanks S.K., Hunter T., and van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372 (1994) 786-791
4. Thomas J.W., Cooley M.A., Broome J.M., et al. The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin. J Biol Chem 274 (1999) 36684-36692
5. Bellis S.L., Miller J.T., and Turner C.E. Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. J Biol Chem 270 (1995) 17437-17441
6. van Nimwegen M.J., Verkoeijen S., van Buren L., Burg D., and van de Water B. Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation. Cancer Res 65 (2005) 4698-4706
7. Hsia D.A., Mitra S.K., Hauck C.R., et al. Differential regulation of cell motility and invasion by FAK. J Cell Biol 160 (2003) 753-767
8. Frisch S.M., Vuori K., Ruoslahti E., and Chan-Hui P.Y. Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 134 (1996) 793-799
9. Oktay M.H., Oktay K., Hamele-Bena D., Buyuk A., and Koss L.G. Focal adhesion kinase as a marker of malignant phenotype in breast and cervical carcinomas. Hum Pathol 34 (2003) 240-245
10. Madan R., Smolkin M.B., Cocker R., Fayyad R., and Oktay M.H. Focal adhesion proteins as markers of malignant transformation and prognostic indicators in breast carcinoma. Hum Pathol 37 (2006) 9-15
11. Kornberg L.J. Focal adhesion kinase and its potential involvement in tumor invasion and metastasis. Head Neck 20 (1998) 745-752
12. Cance W.G., Harris J.E., Iacocca M.V., et al. Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res 6 (2000) 2417-2423
13. Owens L.V., Xu L., Craven R.J., et al. Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res 55 (1995) 2752-2755
14. Han N.M., Fleming R.Y., Curley S.A., and Gallick G.E. Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation. Ann Surg Oncol 4 (1997) 264-268
15. Weiner T.M., Liu E.T., Craven R.J., and Cance W.G. Expression of focal adhesion kinase gene and invasive cancer. Lancet 342 (1993) 1024-1025
16. Lark A.L., Livasy C.A., Calvo B., et al. Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses. Clin Cancer Res 9 (2003) 215-222
17. Ayaki M., Komatsu K., Mukai M., et al. Reduced expression of focal adhesion kinase in liver metastases compared with matched primary human colorectal adenocarcinomas. Clin Cancer Res 7 (2001) 3106-3112
18. Sood A.K., Coffin J.E., Schneider G.B., et al. Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion. Am J Pathol 165 (2004) 1087-1095
19. Fujii T., Koshikawa K., Nomoto S., et al. Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor. J Hepatol 41 (2004) 104-111
20. Recher C., Ysebaert L., Beyne-Rauzy O., et al. Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis. Cancer Res 64 (2004) 3191-3197
21. Itoh S., Maeda T., Shimada M., et al. Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. Clin Cancer Res 10 (2004) 2812-2817
22. Theocharis S.E., Kouraklis G.P., Kakisis J.D., et al. Focal adhesion kinase expression is not a prognostic predictor in colon adenocarcinoma patients. Eur J Surg Oncol 29 (2003) 571-574
23. Aligayer H., Boyd D.D., Heiss M.M., et al. Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis. Cancer 94 (2002) 344-351
24. Hanks S.K., Ryzhova L., Shin N.Y., and Brabek J. Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Front Biosci 8 (2003) d982-d996
25. Brabletz T., Jung A., Spaderna S., Hlubek F., and Kirchner T. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 5 (2005) 744-749