The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition

Neuropharmacology

Volumn 55, Issue 7, 2008, Pages 1251-1258

  Wall, Mark J ^a   Wigmore, Geoffery ^a   Lopatář, Ján ^a   Frenguelli, Bruno G ^a   Dale, Nicholas ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

ATP; Biosensor; Cerebellum; Hippocampus; NTPDase; Synaptic transmission

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 8 CYCLOPENTYLTHEOPHYLLINE; ADENOSINE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; BETA,GAMMA DIBROMOMETHYLENE 6 N,N DIETHYLADENOSINE TRIPHOSPHATE; ENZYME INHIBITOR; KYNURENIC ACID; METAL COMPLEX; NUCLEOTIDASE; NUCLEOTIDE; PURINERGIC P2 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; RECOMBINANT ENZYME; SODIUM POLYOXOTUNGSTATE; TUNGSTEN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOSENSOR; CEREBELLUM; CONTROLLED STUDY; ENZYME INHIBITION; EXCITATORY POSTSYNAPTIC POTENTIAL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SYNAPTIC TRANSMISSION;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; BIOSENSING TECHNIQUES; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLORING AGENTS; ENZYME INHIBITORS; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; HIPPOCAMPUS; PURKINJE CELLS; ROSANILINE DYES; SYNAPTIC TRANSMISSION; TUNGSTEN COMPOUNDS;

EID: 54049087303     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.08.005     Document Type: Article

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