A depletable pool of adenosine in area CA1 of the rat hippocampus

Journal of Neuroscience

Volumn 21, Issue 7, 2001, Pages 2298-2307

  Pearson, Tim ^b   Nuritova, Feruza ^b   Caldwell, Darren ^b   Dale, Nicholas ^a   Frenguelli, Bruno G ^b  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Adenosine; Adenosine deaminase; Depletion; Glutamate; Head injury; Hippocampus; Hypoxia; Ischemia; Neuroprotection; Nucleoside phosphorylase; Replenishment; Sensor; Stroke; TBI; TIA; Xanthine oxidase

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR ANTAGONIST; GLUTAMATE RECEPTOR; NUCLEOSIDE PHOSPHORYLASE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN SLICE; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; HEAD INJURY; HIPPOCAMPUS; MALE; NEUROPROTECTION; NONHUMAN; NUCLEOSIDE TRANSPORT; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; REOXYGENATION; STRESS; SYNAPTIC TRANSMISSION;

EID: 0035313598     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-07-02298.2001     Document Type: Article

References (52)

1. Endogenous adenosine mediates the sustained inhibition of excitatory synaptic transmission during moderate hypoxia
2. Release of adenosine from ischemic brain
3. Pathology
4. Ischemic tolerance in the brain
5. Anoxia produces smaller changes in synaptic transmission, membrane potential, and input resistance in immature rat hippocampus
6. Delayed production of adenosine underlies temporal modulation of swimming in frog embryo
7. Direct measurement of adenosine release during hypoxia in the CA1 region of the rat hippocampal slice
8. Adenosine: Does it have a neuroprotective role after all?
9. Adenosine depletion alters postictal hypoxic cerebral vasodilation in the newborn pig
10. Concentration dependence of adenosine and the protection of rat cortical neurones during anoxia
11. Adenosine and suppression of seizures
12. Extracellular adenosine concentrations in hippocampal brain slices and the tonic inhibitory modulation of evoked excitatory responses
13. Potassium conductance causing hyperpolarization of CA1 hippocampal neurons during hypoxia
14. Adenosine antagonists delay hypoxia-induced depressions of neuronal activity in hippocampal brain slice
15. The effects of metabolic stress on glutamate receptor-mediated depolarisations in the in vitro rat hippocampal slice
16. Reduction in cerebral ischemic injury in the newborn rat by potentiation of endogenous adenosine
17. Dissociation of adenosine levels from bioenergetic state in experimental brain trauma: Potential role in secondary injury
18. Increased vulnerability of the mildly traumatized rat brain to cerebral ischemia: The use of controlled secondary ischemia as a research tool to identify common or different mechanisms contributing to mechanical and ischemic brain injury
19. Adenosine kinase inhibition protects brain against transient focal ischemia in rats
20. Nucleoside transporter of cerebral microvessels and choroid plexus
21. Adenosine antagonists prevent hypoxia-induced depression of excitatory but not inhibitory synaptic currents
22. Neuronal damage following non-lethal but repeated cerebral ischemia in the gerbil
23. Neuronal damage following repeated brief ischemia in the gerbil
24. Role of the excitotoxic mechanism in the development of neuronal damage following repeated brief cerebral ischemia in the gerbil: Protective effects of MK-801 and pentobarbital
25. Repeated focal cerebral ischemia in gerbils is associated with development of infarction
26. Increase in plasma adenosine during brain ischemia in man: A study during transient ischemic attacks, and stroke
27. Effects of experimental fluid-percussion injury of the brain on cerebrovascular reactivity of hypoxia and to hypercapnia
28. Differing neurochemical and morphological sequelae of global ischemia: Comparison of single- and multiple-insult paradigms
29. Pre- and peristroke treatment with the adenosine kinase inhibitor, 5′-deoxyiodotubercidin, significantly reduces infarct volume after temporary occlusion of the middle cerebral artery in rats
30. Effect of repeated cerebral ischemia on metabolites and metabolic rate in gerbil cortex
31. Effects of pretreatment with sublethal ischemia on the extracellular glutamate concentrations during secondary ischemia in the gerbil hippocampus evaluated with intracerebral microdialysis
32. Selective vulnerability of hippocampal CA3 neurons to hypoxia after mild concussion in the rat
33. Adenosine and the concept of retaliatory metabolites
34. Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats
35. Volume-regulated anion channels do not contribute extracellular adenosine during the hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus
36. Investigations into the adenosine outflow from hippocampal slices evoked by ischemia-like conditions
37. Rapid preconditioning protects rats against ischemic neuronal damage after 3 but not 7 d of reperfusion following global cerebral ischemia
38. Deoxycoformycin antagonizes ischemia-induced neuronal degeneration
39. Neuroprotective role of adenosine in cerebral ischaemia
40. Hippocampal synapses: Do they talk to their neighbours?
41. Cerebral metabolism in ischaemia: Neurochemical basis for therapy
42. Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice
43. Neuroprotective effects of adenosine in cerebral ischemia: Window of opportunity
44. Experimental model for repetitive ischemic attacks in the gerbil: The cumulative effect of repeated ischemic insults
45. Extracellular ischaemia markers in repeated global ischaemia and secondary hypoxaemia monitored by microdialysis in rat brain
46. Neonatal seizures
47. Adenosine and cerebral ischemia: Therapeutic future or death of a brave concept?
48. Adenosine: A sensitive indicator of cerebral ischemia during carotid endarterectomy
49. Changes in brain adenosine during bicuculline-induced seizures in rats. Effects of hypoxia and altered systemic blood pressure
50. The effect of age on susceptibility to hypoxic-ischemic brain damage
51. Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms
52. Adenosine release is a major cause of failure of synaptic transmission during hypoglycaemia in rat hippocampal slices