메뉴 건너뛰기




Volumn 18, Issue 3, 2008, Pages 245-250

L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; BETA1 INTEGRIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FOCAL ADHESION KINASE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NERVE CELL ADHESION MOLECULE; NERVE CELL ADHESION MOLECULE CHL1; NERVE CELL ADHESION MOLECULE L1; NEUROPILIN 1; PLATELET DERIVED GROWTH FACTOR RECEPTOR; POLYSIALIC ACID; PROTEIN KINASE FYN; PROTEIN TYROSINE PHOSPHATASE; SCLEROPROTEIN; SEMAPHORIN 3A; SYNTAXIN; UNCLASSIFIED DRUG;

EID: 53949096095     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.conb.2008.07.015     Document Type: Review
Times cited : (186)

References (47)
  • 1
    • 33845882730 scopus 로고    scopus 로고
    • Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration
    • Maness P.F., and Schachner M. Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration. Nat Neurosci 10 (2007) 19-26
    • (2007) Nat Neurosci , vol.10 , pp. 19-26
    • Maness, P.F.1    Schachner, M.2
  • 2
    • 0037096430 scopus 로고    scopus 로고
    • The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins
    • Thelen K., Kedar V., Panicker A.K., Schmid R.S., Midkiff B.R., and Maness P.F. The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins. J Neurosci 22 (2002) 4918-4931
    • (2002) J Neurosci , vol.22 , pp. 4918-4931
    • Thelen, K.1    Kedar, V.2    Panicker, A.K.3    Schmid, R.S.4    Midkiff, B.R.5    Maness, P.F.6
  • 3
    • 0034717802 scopus 로고    scopus 로고
    • Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment
    • Silletti S., Mei F., Sheppard D., and Montgomery A.M. Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment. J Cell Biol 149 (2000) 1485-1502
    • (2000) J Cell Biol , vol.149 , pp. 1485-1502
    • Silletti, S.1    Mei, F.2    Sheppard, D.3    Montgomery, A.M.4
  • 4
    • 11244255723 scopus 로고    scopus 로고
    • Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling
    • Schmid R.S., Midkiff B.R., Kedar V.P., and Maness P.F. Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling. Neuroreport 15 (2004) 2791-2794
    • (2004) Neuroreport , vol.15 , pp. 2791-2794
    • Schmid, R.S.1    Midkiff, B.R.2    Kedar, V.P.3    Maness, P.F.4
  • 5
    • 0034214218 scopus 로고    scopus 로고
    • A MAP kinase signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis
    • Schmid R.S., Pruitt W.M., and Maness P.F. A MAP kinase signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis. J Neurosci 11 (2000) 4177-4188
    • (2000) J Neurosci , vol.11 , pp. 4177-4188
    • Schmid, R.S.1    Pruitt, W.M.2    Maness, P.F.3
  • 6
    • 3142733866 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion
    • Silletti S., Yebra M., Perez B., Cirulli V., McMahon M., and Montgomery A.M. Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. J Biol Chem 279 (2004) 28880-28888
    • (2004) J Biol Chem , vol.279 , pp. 28880-28888
    • Silletti, S.1    Yebra, M.2    Perez, B.3    Cirulli, V.4    McMahon, M.5    Montgomery, A.M.6
  • 7
    • 38049048081 scopus 로고    scopus 로고
    • Organizing the fluid membrane bilayer: diseases linked to spectrin and ankyrin
    • Bennett V., and Healy J. Organizing the fluid membrane bilayer: diseases linked to spectrin and ankyrin. Trends Mol Med 14 (2008) 28-36
    • (2008) Trends Mol Med , vol.14 , pp. 28-36
    • Bennett, V.1    Healy, J.2
  • 8
    • 33744764926 scopus 로고    scopus 로고
    • MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin binding site regulates neuronal growth
    • Whittard J.D., Sakurai T., Cassella M.R., Gazdoiu M., and Felsenfeld D.P. MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin binding site regulates neuronal growth. Mol Biol Cell 17 (2006) 2696-2706
    • (2006) Mol Biol Cell , vol.17 , pp. 2696-2706
    • Whittard, J.D.1    Sakurai, T.2    Cassella, M.R.3    Gazdoiu, M.4    Felsenfeld, D.P.5
  • 9
    • 38149141710 scopus 로고    scopus 로고
    • L1 interaction with ankyrin regulates mediolateral topography in the retinocollicular projection
    • Buhusi M., Schlatter M.C., Demyanenko G.P., Thresher R., and Maness P.F. L1 interaction with ankyrin regulates mediolateral topography in the retinocollicular projection. J Neurosci 28 (2008) 177-188
    • (2008) J Neurosci , vol.28 , pp. 177-188
    • Buhusi, M.1    Schlatter, M.C.2    Demyanenko, G.P.3    Thresher, R.4    Maness, P.F.5
  • 10
    • 5444260773 scopus 로고    scopus 로고
    • Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at Purkinje axon initial segment
    • The authors used BAC transgenic reporter mice expressing green fluorescent protein in an interneuron subpopulation to show that a subcellular gradient of the Neurofascin 186 isoform along the dendritic-somal-axon initial segment axis of cerebellar Purkinje cells is formed by the direct interaction with an ankyrin B isoform, and is responsible for axon targeting of basket interneurons to the axon initial segment. AnkyrinG-associated Neurofascin 186 is suggested to be required for the formation or stabilization of pinceau synapses at the axon initial segment.
    • Ango F., di Cristo G., Higashiyama H., Bennett V., Wu P., and Huang Z.J. Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at Purkinje axon initial segment. Cell 119 (2004) 257-272. The authors used BAC transgenic reporter mice expressing green fluorescent protein in an interneuron subpopulation to show that a subcellular gradient of the Neurofascin 186 isoform along the dendritic-somal-axon initial segment axis of cerebellar Purkinje cells is formed by the direct interaction with an ankyrin B isoform, and is responsible for axon targeting of basket interneurons to the axon initial segment. AnkyrinG-associated Neurofascin 186 is suggested to be required for the formation or stabilization of pinceau synapses at the axon initial segment.
    • (2004) Cell , vol.119 , pp. 257-272
    • Ango, F.1    di Cristo, G.2    Higashiyama, H.3    Bennett, V.4    Wu, P.5    Huang, Z.J.6
  • 11
    • 7044222373 scopus 로고    scopus 로고
    • Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex
    • This study demonstrated for the first time a function for a cell adhesion molecule, CHL1, in cortical neuron migration and laminar positioning. CHL1 knockout mice were crossed with a fluorescent reporter strain (Thy1-YFP) to label layer V pyramidal neurons to reveal malpositioning of neurons to deeper layers specifically in caudal cortical areas (somatosensory and visual cortex) where CHL1 is normally expressed.
    • Demyanenko G.P., Schachner M., Anton E., Schmid R., Feng G., Sanes J., and Maness P.F. Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex. Neuron 44 (2004) 423-437. This study demonstrated for the first time a function for a cell adhesion molecule, CHL1, in cortical neuron migration and laminar positioning. CHL1 knockout mice were crossed with a fluorescent reporter strain (Thy1-YFP) to label layer V pyramidal neurons to reveal malpositioning of neurons to deeper layers specifically in caudal cortical areas (somatosensory and visual cortex) where CHL1 is normally expressed.
    • (2004) Neuron , vol.44 , pp. 423-437
    • Demyanenko, G.P.1    Schachner, M.2    Anton, E.3    Schmid, R.4    Feng, G.5    Sanes, J.6    Maness, P.F.7
  • 13
    • 24944585820 scopus 로고    scopus 로고
    • Reelin, integrin and Dab1 interactions during embryonic cerebral cortical development
    • Schmid R.S., Jo R., Shelton S., Kreidberg J.A., and Anton E.S. Reelin, integrin and Dab1 interactions during embryonic cerebral cortical development. Cereb Cortex 15 (2005) 1632-1636
    • (2005) Cereb Cortex , vol.15 , pp. 1632-1636
    • Schmid, R.S.1    Jo, R.2    Shelton, S.3    Kreidberg, J.A.4    Anton, E.S.5
  • 14
    • 37249047911 scopus 로고    scopus 로고
    • Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex
    • Belvindrah R., Graus-Porta D., Goebbels S., Nave K.A., and Muller U. Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci 27 (2007) 13854-13865
    • (2007) J Neurosci , vol.27 , pp. 13854-13865
    • Belvindrah, R.1    Graus-Porta, D.2    Goebbels, S.3    Nave, K.A.4    Muller, U.5
  • 16
    • 38049051162 scopus 로고    scopus 로고
    • Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha
    • Ye H., Tan Y.L., Ponniah S., Takeda Y., Wang S.Q., Schachner M., Watanabe K., Pallen C.J., and Xiao Z.C. Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha. EMBO J 27 (2008) 188-200
    • (2008) EMBO J , vol.27 , pp. 188-200
    • Ye, H.1    Tan, Y.L.2    Ponniah, S.3    Takeda, Y.4    Wang, S.Q.5    Schachner, M.6    Watanabe, K.7    Pallen, C.J.8    Xiao, Z.C.9
  • 17
    • 18644374595 scopus 로고    scopus 로고
    • Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex
    • Sasaki Y., Cheng C., Uchida Y., Nakajima O., Ohshima T., Yagi T., Taniguchi M., Nakayama T., Kishida R., Kudo Y., et al. Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35 (2002) 907-920
    • (2002) Neuron , vol.35 , pp. 907-920
    • Sasaki, Y.1    Cheng, C.2    Uchida, Y.3    Nakajima, O.4    Ohshima, T.5    Yagi, T.6    Taniguchi, M.7    Nakayama, T.8    Kishida, R.9    Kudo, Y.10
  • 19
    • 0034611809 scopus 로고    scopus 로고
    • Semaphorin 3A is a chemoattractant for cortical apical dendrites
    • Polleux F., Morrow T., and Ghosh A. Semaphorin 3A is a chemoattractant for cortical apical dendrites. Nature 404 (2000) 567-573
    • (2000) Nature , vol.404 , pp. 567-573
    • Polleux, F.1    Morrow, T.2    Ghosh, A.3
  • 21
    • 0033678716 scopus 로고    scopus 로고
    • Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance [see comments]
    • This important work revealed a novel function for L1 in mediating repellent axon guidance and growth cone collapse to Sema3A. Using cocultures of cortical slices and spinal cord explants from wild-type and L1-minus mice, the authors demonstrate that this mechanism underlies repellent guidance of cortico-spinal tract axons in response to Sema3A in the ventral spinal cord, which may contribute guidance at the pyramidal decussation in vivo. It is also shown that L1 forms a stable cis-interacting complex with the Sema3A receptor Neuropilin-1, and that soluble L1 protein as a ligand converts the repulsive response into attraction.
    • Castellani V., Chedotal A., Schachner M., Faivre-Sarrailh C., and Rougon G. Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance [see comments]. Neuron 27 (2000) 237-249. This important work revealed a novel function for L1 in mediating repellent axon guidance and growth cone collapse to Sema3A. Using cocultures of cortical slices and spinal cord explants from wild-type and L1-minus mice, the authors demonstrate that this mechanism underlies repellent guidance of cortico-spinal tract axons in response to Sema3A in the ventral spinal cord, which may contribute guidance at the pyramidal decussation in vivo. It is also shown that L1 forms a stable cis-interacting complex with the Sema3A receptor Neuropilin-1, and that soluble L1 protein as a ligand converts the repulsive response into attraction.
    • (2000) Neuron , vol.27 , pp. 237-249
    • Castellani, V.1    Chedotal, A.2    Schachner, M.3    Faivre-Sarrailh, C.4    Rougon, G.5
  • 23
    • 0037011182 scopus 로고    scopus 로고
    • Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A
    • Castellani V., De Angelis E., Kenwrick S., and Rougon G. Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A. EMBO J 21 (2002) 6348-6357
    • (2002) EMBO J , vol.21 , pp. 6348-6357
    • Castellani, V.1    De Angelis, E.2    Kenwrick, S.3    Rougon, G.4
  • 24
    • 0345550397 scopus 로고    scopus 로고
    • FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies
    • Beggs H.E., Schahin-Reed D., Zang K., Goebbels S., Nave K.A., Gorski J., Jones K.R., Sretavan D., and Reichardt L.F. FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron 40 (2003) 501-514
    • (2003) Neuron , vol.40 , pp. 501-514
    • Beggs, H.E.1    Schahin-Reed, D.2    Zang, K.3    Goebbels, S.4    Nave, K.A.5    Gorski, J.6    Jones, K.R.7    Sretavan, D.8    Reichardt, L.F.9
  • 26
    • 0037193470 scopus 로고    scopus 로고
    • Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis
    • Niethammer P., Delling M., Sytnyk V., Dityatev A., Fukami K., and Schachner M. Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J Cell Biol 157 (2002) 521-532
    • (2002) J Cell Biol , vol.157 , pp. 521-532
    • Niethammer, P.1    Delling, M.2    Sytnyk, V.3    Dityatev, A.4    Fukami, K.5    Schachner, M.6
  • 27
    • 0034653487 scopus 로고    scopus 로고
    • Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway
    • Kolkova K., Novitskaya V., Pedersen N., Berezin V., and Bock E. Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway. J Neurosci 20 (2000) 2238-2246
    • (2000) J Neurosci , vol.20 , pp. 2238-2246
    • Kolkova, K.1    Novitskaya, V.2    Pedersen, N.3    Berezin, V.4    Bock, E.5
  • 28
    • 0038488948 scopus 로고    scopus 로고
    • The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands
    • The authors find that NCAM can act as a coreceptor for the GDNF receptor GFRα1 to activate FAK and Fyn signaling without the known GDNF signaling receptor RET. The NCAM-GFRα1 interaction downregulates NCAM-NCAM homophilic binding, suggesting that cis-interacting GFRα1 induces conformation changes in NCAM that regulates its ability to interact with different ligands.
    • Paratcha G., Ledda F., and Ibanez C.F. The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands. Cell 113 (2003) 867-879. The authors find that NCAM can act as a coreceptor for the GDNF receptor GFRα1 to activate FAK and Fyn signaling without the known GDNF signaling receptor RET. The NCAM-GFRα1 interaction downregulates NCAM-NCAM homophilic binding, suggesting that cis-interacting GFRα1 induces conformation changes in NCAM that regulates its ability to interact with different ligands.
    • (2003) Cell , vol.113 , pp. 867-879
    • Paratcha, G.1    Ledda, F.2    Ibanez, C.F.3
  • 29
    • 14644400390 scopus 로고    scopus 로고
    • GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons
    • Pozas E., and Ibanez C.F. GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons. Neuron 45 (2005) 701-713
    • (2005) Neuron , vol.45 , pp. 701-713
    • Pozas, E.1    Ibanez, C.F.2
  • 30
    • 30044438894 scopus 로고    scopus 로고
    • Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule
    • The authors generated PSA-negative, NCAM-positive mice by deletion of two polysialyltransferase genes, STX and PST, to reveal for the first time that loss of a glycan can be more important than loss of the glyco-conjugated protein for brain development. Loss of PSA caused a more severe phenotype of axonal tract defects, hydrocephalus, and lethality, which were rescued in a triple knockouts lacking NCAM. Thus, a major function of PSA is to mask NCAM function at certain times and places enabling NCAM contacts to form in an orderly manner.
    • Weinhold B., Seidenfaden R., Rockle I., Muhlenhoff M., Schertzinger F., Conzelmann S., Marth J.D., Gerardy-Schahn R., and Hildebrandt H. Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule. J Biol Chem 280 (2005) 42971-42977. The authors generated PSA-negative, NCAM-positive mice by deletion of two polysialyltransferase genes, STX and PST, to reveal for the first time that loss of a glycan can be more important than loss of the glyco-conjugated protein for brain development. Loss of PSA caused a more severe phenotype of axonal tract defects, hydrocephalus, and lethality, which were rescued in a triple knockouts lacking NCAM. Thus, a major function of PSA is to mask NCAM function at certain times and places enabling NCAM contacts to form in an orderly manner.
    • (2005) J Biol Chem , vol.280 , pp. 42971-42977
    • Weinhold, B.1    Seidenfaden, R.2    Rockle, I.3    Muhlenhoff, M.4    Schertzinger, F.5    Conzelmann, S.6    Marth, J.D.7    Gerardy-Schahn, R.8    Hildebrandt, H.9
  • 31
    • 34748840775 scopus 로고    scopus 로고
    • Polysialic acid-directed migration and differentiation of neural precursors are essential for mouse brain development
    • Angata K., Huckaby V., Ranscht B., Terskikh A., Marth J.D., and Fukuda M. Polysialic acid-directed migration and differentiation of neural precursors are essential for mouse brain development. Mol Cell Biol 27 (2007) 6659-6668
    • (2007) Mol Cell Biol , vol.27 , pp. 6659-6668
    • Angata, K.1    Huckaby, V.2    Ranscht, B.3    Terskikh, A.4    Marth, J.D.5    Fukuda, M.6
  • 34
    • 84954358667 scopus 로고    scopus 로고
    • NCAM in neuropsychiatric and neurodegenerative disorders
    • [epub ahead of print]
    • Brennaman L.H., and Maness P.F. NCAM in neuropsychiatric and neurodegenerative disorders. Neurochem Res (2008) [epub ahead of print]
    • (2008) Neurochem Res
    • Brennaman, L.H.1    Maness, P.F.2
  • 35
    • 37249033781 scopus 로고    scopus 로고
    • NCAM is ubiquitylated, endocytosed and recycled in neurons
    • Diestel S., Schaefer D., Cremer H., and Schmitz B. NCAM is ubiquitylated, endocytosed and recycled in neurons. J Cell Sci 120 (2007) 4035-4049
    • (2007) J Cell Sci , vol.120 , pp. 4035-4049
    • Diestel, S.1    Schaefer, D.2    Cremer, H.3    Schmitz, B.4
  • 36
    • 41149135274 scopus 로고    scopus 로고
    • Developmental regulation of GABAergic interneuron branching and synaptic development in the prefrontal cortex by soluble neural cell adhesion molecule
    • Brennaman L.H., and Maness P.F. Developmental regulation of GABAergic interneuron branching and synaptic development in the prefrontal cortex by soluble neural cell adhesion molecule. Mol Cell Neurosci 37 (2008) 781-793
    • (2008) Mol Cell Neurosci , vol.37 , pp. 781-793
    • Brennaman, L.H.1    Maness, P.F.2
  • 39
    • 0034730463 scopus 로고    scopus 로고
    • Dysregulation of the neural cell adhesion molecule and neuropsychiatric disorders
    • Vawter M.P. Dysregulation of the neural cell adhesion molecule and neuropsychiatric disorders. Eur J Pharmacol 405 (2000) 385-395
    • (2000) Eur J Pharmacol , vol.405 , pp. 385-395
    • Vawter, M.P.1
  • 40
    • 84954358611 scopus 로고    scopus 로고
    • Neural cell adhesion molecule in cancer: expression and mechanisms
    • [epub ahead of print]
    • Zecchini S., and Cavallaro U. Neural cell adhesion molecule in cancer: expression and mechanisms. Neurochem Res (2008) [epub ahead of print]
    • (2008) Neurochem Res
    • Zecchini, S.1    Cavallaro, U.2
  • 43
    • 39149107444 scopus 로고    scopus 로고
    • Antibodies directed against L1-CAM synergize with Genistein in inhibiting growth and survival pathways in SKOV3ip human ovarian cancer cells
    • Novak-Hofer I., Cohrs S., Grunberg J., Friedli A., Schlatter M.C., Pfeifer M., Altevogt P., and Schubiger P.A. Antibodies directed against L1-CAM synergize with Genistein in inhibiting growth and survival pathways in SKOV3ip human ovarian cancer cells. Cancer Lett 261 (2008) 193-204
    • (2008) Cancer Lett , vol.261 , pp. 193-204
    • Novak-Hofer, I.1    Cohrs, S.2    Grunberg, J.3    Friedli, A.4    Schlatter, M.C.5    Pfeifer, M.6    Altevogt, P.7    Schubiger, P.A.8
  • 44
    • 0034639938 scopus 로고    scopus 로고
    • Neural cell recognition molecule L1: relating biological complexity to human disease mutations
    • Kenwrick S., Watkins A., and Angelis E.D. Neural cell recognition molecule L1: relating biological complexity to human disease mutations. Hum Mol Genet 9 (2000) 879-886
    • (2000) Hum Mol Genet , vol.9 , pp. 879-886
    • Kenwrick, S.1    Watkins, A.2    Angelis, E.D.3
  • 47
    • 34247103564 scopus 로고    scopus 로고
    • NCAM1 association study of bipolar disorder and schizophrenia: polymorphisms and alternatively spliced isoforms lead to similarities and differences
    • Atz M.E., Rollins B., and Vawter M.P. NCAM1 association study of bipolar disorder and schizophrenia: polymorphisms and alternatively spliced isoforms lead to similarities and differences. Psychiatr Genet 17 (2007) 55-67
    • (2007) Psychiatr Genet , vol.17 , pp. 55-67
    • Atz, M.E.1    Rollins, B.2    Vawter, M.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.