Identification of residues important for cleavage of the extracellular signaling peptide CSF of Bacillus subtilis from its precursor protein

Journal of Bacteriology

Volumn 190, Issue 20, 2008, Pages 6668-6675

  Lanigan Gerdes, Sara ^a   Briceno, Geraldine ^a   Dooley, Alek N ^b   Faull, Kym F ^b   Lazazzera, Beth A ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BACTERIAL PROTEIN; CSF PEPTIDE; MUTANT PROTEIN; PEPTIDE; PHOA PROTEIN; PHRC PROTEIN; PROTEIN PRECURSOR; SIGNAL PEPTIDE; SUBTILISIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; CARBOXY TERMINAL SEQUENCE; CELL WALL; CONTROLLED STUDY; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; STRAIN DIFFERENCE; WHOLE CELL; WILD TYPE;

ALKALINE PHOSPHATASE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTIFICIAL GENE FUSION; BACILLUS SUBTILIS; BACTERIAL PROTEINS; GENES, REPORTER; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SORTING SIGNALS; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS;

BACILLUS SUBTILIS; POSIBACTERIA;

EID: 53849146360     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.00910-08     Document Type: Article

References (36)

1. Auchtung, J. M., C. A. Lee, and A. D. Grossman. 2006. Modulation of the ComA-dependent quorum response in Bacillus subtilis by multiple Rap proteins and Phr peptides. J. Bacteriol. 188:5273-5285.
2. Auchtung, J. M., C. A. Lee, R. E. Monson, A. P. Lehman, and A. D. Grossman. 2005. Regulation of a Bacillus subtilis mobile genetic element by intercellular signaling and the global DNA damage response. Proc. Natl. Acad. Sci. USA 102:12554-12559.
3. Bassler, B., P. Gibbons, and S. Roseman. 1989. Chemotaxis to chitin oligosaccharides by Vibrio furnissii, a chitinivorous marine bacterium. Biochem. Biophys. Res. Commun. 161:1172-1176.
4. Bongiorni, C., S. Ishikawa, S. Stephenson, N. Ogasawara, and M. Perego. 2005. Synergistic regulation of competence development in Bacillus subtilis by two Rap-Phr systems. J. Bacteriol. 187:4353-4361.
5. Bongiorni, C., R. Stoessel, D. Shoemaker, and M. Perego. 2006. Rap phosphatase of virulence plasmid pXO1 inhibits Bacillus anthracis sporulation. J. Bacteriol. 188:487-498.
6. Comella, N., and A. D. Grossman. 2005. Conservation of genes and processes controlled by the quorum response in bacteria: characterization of genes controlled by the quorum-sensing transcription factor ComA in Bacillus subtilis. Mol. Microbiol. 57:1159-1174.
7. Core, L., and M. Perego. 2003. TPR-mediated interaction of RapC with ComA inhibits response regulator-DNA binding for competence development in Bacillus subtilis. Mol. Microbiol. 49:1509-1522.
8. Guerout-Fleury, A. M., N. Frandsen, and P. Stragier. 1996. Plasmids for ectopic integration in Bacillus subtilis. Gene 180:57-61.
9. Harwood, C. R., and S. M. Cutting. 1990. Molecular biological methods for Bacillus. John Wiley & Sons Ltd, Chichester, England.
10. Hayashi, K., T. Kensuke, K. Kobayashi, N. Ogasawara, and M. Ogura. 2006. Bacillus subtilis RghR (YvaN) represses rapG and rapH, which encode inhibitors of expression of the srfA operon. Mol. Microbiol. 59:1714-1729.
11. Hense, B. A., C. Kuttler, J. Muller, M. Rothballer, A. Hartmann, and J. U. Kreft. 2007. Does efficiency sensing unify diffusion and quorum sensing? Nat. Rev. Microbiol. 5:230-239.
12. Jiang, M., R. Grau, and M. Perego. 2000. Differential processing of propeptide inhibitors of Rap phosphatases in Bacillus subtilis. J. Bacteriol. 182:303-310.
13. Kanaya, S., Y. Yamada, Y. Kudo, and T. Ikemura. 1999. Studies of codon usage and tRNA genes of 18 unicellular organisms and quantification of Bacillus subtilis tRNAs: gene expression level and species-specific diversity of codon usage based on multivariate analysis. Gene 238:143-155.
14. Koetje, E. J., A. Hajdo-Milasinovic, R. Kiewiet, S. Bron, and H. Tjalsma. 2003. A plasmid-borne Rap-Phr system of Bacillus subtilis can mediate cell-density controlled production of extracellular proteases. Microbiology 149:19-28.
15. Lanigan-Gerdes, S., A. N. Dooley, K. F. Faull, and B. A. Lazazzera. 2007. Identification of subtilisin, Epr and Vpr as enzymes that produce CSF, an extracellular signalling peptide of Bacillus subtilis. Mol. Microbiol. 65:1321-1333.
16. Lazazzera, B. A., I. G. Kurtser, R. S. McQuade, and A. D. Grossman. 1999. An autoregulatory circuit affecting peptide signaling in Bacillus subtilis. J. Bacteriol. 181:5193-5200.
17. Lazazzera, B. A., J. M. Solomon, and A. D. Grossman. 1997. An exported peptide functions intracellularly to contribute to cell density signaling in B. subtilis. Cell 89:917-925.
18. LeDeaux, J. R., and A. D. Grossman. 1995. Isolation and characterization of kinC, a gene that encodes a sensor kinase homologous to the sporulation sensor kinases KinA and KinB in Bacillus subtilis. J. Bacteriol. 177:166-175.
19. Lyon, G. J., and R. P. Novick. 2004. Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria. Peptides 25:1389-1403.
20. Magnuson, R., J. Solomon, and A. D. Grossman. 1994. Biochemical and genetic characterization of a competence pheromone from B. subtilis. Cell 77:207-216.
21. Mueller, J. P., G. Bukusoglu, and A. L. Sonenshein. 1992. Transcriptional regulation of Bacillus subtilis glucose starvation-inducible genes: control of gsiA by the ComP-ComA signal transduction system. J. Bacteriol. 174:4361-4373.
22. Nicholson, W. L., and P. Setlow. 1990. Sporulation, germination, and outgrowth, p. 391-429. In C. R. Harwood and S. M. Cutting (ed.), Molecular biological methods for Bacillus. John Wiley & Sons, Chichester, England.
23. Ogura, M., K. Shimane, K. Asai, N. Ogasawara, and T. Tanaka. 2003. Binding of response regulator DegU to the aprE promoter is inhibited by RapG, which is counteracted by extracellular PhrG in Bacillus subtilis. Mol. Microbiol. 49:1685-1697.
24. Ogura, M., H. Yamaguchi, K. Yoshida, Y. Fujita, and T. Tanaka. 2001. DNA microarray analysis of Bacillus subtilis DegU, ComA and PhoP regulons: an approach to comprehensive analysis of B. subtilis two-component regulatory systems. Nucleic Acids Res. 29:3804-3813.
25. Perego, M. 1997. A peptide export-import control circuit modulating bacterial development regulates protein phosphatases of the phosphorelay. Proc. Natl. Acad. Sci. USA 94:8612-8617.
26. Perego, M., and J. A. Brannigan. 2001. Pentapeptide regulation of aspartylphosphate phosphatases. Peptides 22:1541-1547.
27. Perego, M., and J. A. Hoch. 1988. Sequence analysis and regulation of the hpr locus, a regulatory gene for protease production and sporulation in Bacillus subtilis. J. Bacteriol. 170:2560-2567.
28. Pottathil, M., and B. A. Lazazzera. 2003. The extracellular Phr peptide-Rap phosphatase signaling circuit of Bacillus subtilis. Front. Biosci. 8:32-45.
29. Slamti, L., and D. Lereclus. 2002. A cell-cell signaling peptide activates the PlcR virulence regulon in bacteria of the Bacillus cereus group. EMBO J. 21:4550-4559.
30. Smits, W. K., C. Bongiorni, J. W. Veening, L. W. Hamoen, O. P. Kuipers, and M. Perego. 2007. Temporal separation of distinct differentiation pathways by a dual specificity Rap-Phr system in Bacillus subtilis. Mol. Microbiol. 65:103-120.
31. Solomon, J. M., B. A. Lazazzera, and A. D. Grossman. 1996. Purification and characterization of an extracellular peptide factor that affects two different developmental pathways in Bacillus subtilis. Genes Dev. 10:2014-2024.
32. Solomon, J. M., R. Magnuson, A. Srivastava, and A. D. Grossman. 1995. Convergent sensing pathways mediate response to two extracellular competence factors in Bacillus subtilis. Genes Dev. 9:547-558.
33. Stephenson, S., C. Mueller, M. Jiang, and M. Perego. 2003. Molecular analysis of Phr peptide processing in Bacillus subtilis. J. Bacteriol. 185:4861-4871.
34. Tzeng, Y. L., V. A. Feher, J. Cavanagh, M. Perego, and J. A. Hoch. 1998. Characterization of interactions between a two-component response regulator, Spo0F, and its phosphatase, RapB. Biochemistry 37:16538-16545.
35. Vasantha, N., and E. Freese. 1980. Enzyme changes during Bacillus subtilis sporulation caused by deprivation of guanine nucleotides. J. Bacteriol. 144:1119-1125.
36. Youngman, P., H. Poth, B. Green, K. York, G. Olmedo, and K. Smith (ed.). 1989. Methods for genetic manipulation, cloning, and functional analysis of sporulation genes in Bacillus subtilis. American Society for Microbiology, Washington, DC.