Advances in treatment options of endometriosis

Gynecologic and Obstetric Investigation

Volumn 67, Issue 2, 2009, Pages 81-91

  Özkan, Sebiha ^a,c   Arici, Aydin ^b  

^a KOCAELI UNIVERSITY   (Turkey)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NONE   (Turkey)

Author keywords

Endometriosis; Evidence based treatments; Infertility; Pain

Indexed keywords

ANDROGEN; ANGIOGENESIS INHIBITOR; AROMATASE INHIBITOR; DANAZOL; ESTROGEN; GESTAGEN; GESTRINONE; GONADORELIN; GONADORELIN AGONIST; LEVONORGESTREL; MATRIX METALLOPROTEINASE INHIBITOR; MEDROXYPROGESTERONE; MIFEPRISTONE; NANDROLONE DERIVATIVE; ORAL CONTRACEPTIVE AGENT; PENTOXIFYLLINE; PLACEBO; PROGESTERONE; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

ANALGESIA; BLEEDING; BREAST TENDERNESS; CLINICAL TRIAL; DEPRESSION; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; DYSMENORRHEA; EDEMA; ENDOMETRIOSIS; FERTILITY; FERTILIZATION IN VITRO; HIRSUTISM; HOMEOPATHY; HORMONE SUBSTITUTION; HOT FLUSH; HUMAN; HYSTERECTOMY; INFERTILITY; INSOMNIA; INTRAUTERINE CONTRACEPTIVE DEVICE; INTRAUTERINE INSEMINATION; LAPAROSCOPIC SURGERY; LAPAROSCOPY; LAPAROTOMY; LIBIDO DISORDER; LIVER TOXICITY; MONOTHERAPY; MOOD CHANGE; NAUSEA; OSTEOPOROSIS; PAIN ASSESSMENT; PRIORITY JOURNAL; PSEUDOPREGNANCY; RECURRENT DISEASE; REFLEXOLOGY; REVIEW; SALPINGOOOPHORECTOMY; SIDE EFFECT; THROMBOSIS; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; VAGINA BLEEDING; VAGINAL DRYNESS; VOICE CHANGE; WEIGHT GAIN;

ADULT; COMBINED MODALITY THERAPY; DRUG THERAPY, COMBINATION; ENDOMETRIOSIS; EVIDENCE-BASED MEDICINE; FEMALE; FORECASTING; GYNECOLOGIC SURGICAL PROCEDURES; HORMONE ANTAGONISTS; HORMONES; HUMANS; INFERTILITY, FEMALE; MIDDLE AGED; PAIN MEASUREMENT; PELVIC PAIN; PROGNOSIS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; YOUNG ADULT;

EID: 53849145710     PISSN: 03787346     EISSN: None     Source Type: Journal    
DOI: 10.1159/000163071     Document Type: Review

References (83)

1. Kennedy S, Bergqvist A, Chapron C, et al: ESHRE guidelines for the diagnosis and treatment of endometriosis. Hum Reprod 2005;20:2698-2704.
2. Ozawa Y, Murakami T, Terada Y, et al: Management of the pain associated with endometriosis: an update of the painful problems. Tohoku J Exp Med 2006;210:175-188.
3. Olive DL, Pritts EA: Treatment of endometriosis. N Engl J Med 2001;345:266-275.
4. Adamson D: Surgical management of endometriosis. Semin Reprod Med 2003;21:223-233.
5. Valle RF, Sciarra JJ: Endometriosis: treatment strategies. Ann NY Acad Sci 2003;997:229-239.
6. Giudice LC: Endometriosis. Lancet 2004;364:1789-1799.
7. The Practice Committee of the American Society for Reproductive Medicine: Treatment of pelvic pain associated with endometriosis. Fertil Steril 2006;86:18-27.
8. Olive DL: Medical therapy of endometriosis. Semin Reprod Med 2003;21:209-221.
9. Crosignani PG, Luciano A, Ray A, Bergquist A: Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis associated pain. Obstet Gynecol Survey 2006;61:321-322.
10. Vercellini P, Frontino G, De Giorgi O, Aimi G, Zaina B, Crosignani PG: Comparison of a levonorgestrel releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study. Fertil Steril 2003;80:305-309.
11. Prentice A, Deary AJ, Goldbeck-Wood S, Farquhar C, Smith SK: Gonadotropin-releasing hormone analogues for pain associated with endometriosis. Cochrane Database Syst Rev 2000;2:CD000346.
12. Olive DL, Lindheim SR, Pritts EA: New medical treatments for endometriosis. Best Prac and Res Clin Obstet Gynecol 2004;18:319-328.
13. Proctor ML, Murphy PA: Herbal and dietary therapies for primary and secondary dysmenorrhea (Cochrane Review). In the Cochrane Library, Issue 3. Chichester, Wiley, 2004.
14. Proctor ML, Smith CA, Farquhar CM, Stones RW: Transcutaneous electrical nerve stimulation and acupuncture for primary dysmenorrhea. In the Cochrane Library, Issue 3. Chichester, Wiley, 2004.
15. Sutton C, Pooley AS, Jones KD, Dover RW, Haines P: A prospective randomized double blind controlled trial of laparoscopic uterine nerve ablation in the treatment of pelvic pain associated with endometriosis. Gynecol Endosc 2001;10:217-222.
16. Prentice A, Deary AJ, Bland E: Progestagens and antiprogestagens for pain associated with endometriosis. Cochrane Database Syst Rev 2000;2:CD002122.
17. Moore J, Kennedy S, Prentice A: Modern combined oral contraceptives for pain associated with endometriosis. Cochrane Database Syst Rev 2000;2:CD00101.
18. Selak V, Farquhar C, Prentice A, Singla A: Danazol for pelvic pain associated with endometriosis. Cochrane Database Syst Rev 2001;4:CD000068.
19. Dlugi AM, Miller JD, Knittle J: Lupron depot (leuprolide acetate for depot suspension) in the treatment of endometriosis: a randomized, placebo controlled, double blind study. Fertil Steril 1990;54:419-427.
20. Vercellini P, Trespidi L, Colombo A, et al: A gonadotropin releasing hormone agonist versus a low dose oral contraceptive for pelvic pain associated with endometriosis. Fertil Steril 1993;60:75-79.
21. Vercellini P, Frontino G, De Giorgi O, et al: Continous use of an oral contraceptive (OC) for endometriosis-associated recurrent dysmenorrhea that does not respond to a cyclic pill regimen. Fertil Steril 2003;80:560-563.
22. Ling FW: Randomized controlled trial of depot leuprolide in patients with chronic pelvic pain and clinically suspected endometriosis. Obstet Gynecol 1999;93:51-58.
23. Fedele L, Bianchi S, Viezzoli T, Arcaini L, Cendiani GB: Gestrinone versus danazol in the treatment of endometriosis. Fertil Steril 1989;51:781-785.
24. The Gestrinone Italian Study Group: Gestrinone versus a gonadotropin releasing hormone agonist for the treatment of pelvic pain associated with endometriosis: a multicenter randomised, double blind study. Fertil Steril 1996;66:911-919.
25. Surrey ES, Hornstein MD: Prolonged GnRH agonist and add back therapy for symptomatic endometriosis: long-term follow-up. Obstet Gynecol 2002;99:709-719.
26. Vercellini P, Cortesi I, Crosignani PG: Progestogens for symptomatic endometriosis: a critical analysis of the evidence. Fertil Steril 1997;68:393-401.
27. Telimaa S, Puolakka J, Ronnberg L, Kauppila A: Placebo controlled comparison of danazol and high dose medroxyprogesterone acetate in the treatment of endometriosis. Gynecol Endocrinol 1987;1:13-23.
28. Hornstein MD, Yuzpe AA, Burry KA, Heinrichs LR, Buttram-VL J, Orwoll ES: Prospective randomized double blind trial of 3 versus 6 months of nafarelin therapy for endometriosis associated pelvic pain. Fertil Steril 1995;63:955-962.
29. Surrey ES, Hornstein MD: Prolonged GnRH agonist and add back therapy for symptomatic endometriosis: long-term follow-up. Obstet Gynecol 2002;99:709-719.
30. ESHRE 2007 guidelines for diagnosis and treatment of endometriosis, ESHRE website.
31. Sutton CJ, Ewen SP, Whitelaw N, Haines P: Prospective randomized double blind controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild and moderate endometriosis. Fertil Steril 1994;62:696-700.
32. Sutton CJ, Pooley AS, Ewen SP, Haines P: Follow up report on a randomized controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal to moderate endometriosis. Fertil Steril 1997;68:1070-1074.
33. Vercellini P, Aimi G, Busacca M, Apolone G, Uglietti A, Crosignani PG: Laparoscopic uterosacral ligament resection for dysmenorrhea associated with endometriosis: results of a randomized controlled trial. Fertil Steril 2003;80:310-319.
34. Wilson ML, Farquhar CM, Sinclair OJ, Johnson NP: Surgical interruption of pelvic nerve pathways for primary and secondary dysmenorrhea (Cochrane review); in The Cochrane Library, issue 1. Oxford, Update Software, 2000 (computer disk).
35. Proctor ML, Farquhar CM, Sinclair OJ, Johnson NP: Surgical interruption of pelvic nerve pathways for primary and secondary dysmenorrhea. Cochrane Rev 1999.
36. Jacobson TZ, Barlow DH, Garry R, Koninckx P: Laparoscopic surgery for pelvic pain associated with endometriosis (Cochrane Review). The Cochrane Library, Issue 3. Chichester, Wiley, 2004.
37. Candiani GB, Fedele L, Vercellini P, Bianchi S, Di Nola G: Presacral neurectomy for the treatment of pelvic pain associated with endometriosis: a controlled study. Am Obstet Gynecol 1992;167:100-103.
38. Tjaden B, Schlaff WD, Kimball A, Rock JA: The efficacy of presacral neurectomy for the relief of midline dysmenorrhea. Obstet Gynecol 1990;76:89-91.
39. Zullo F, Palomba S, Zupi E, et al: Effectiveness of presacral neurectomy in women with severe dysmenorrhea caused by endometriosis who were treated with laparoscopic conservative surgery: a 1 year prospective randomized double blind controlled trial. Am J Obstet Gynecol 2003;189:5-10.
40. Beretta P, Franchi M, Ghezzi F, Busacca M, Zupi E, Bolis P: Randomized clinical trial of two laparoscopic treatments of endometriomas: cystectomy versus drainage and coagulation. Fertil Steril 1998;70:1176-1180.
41. Namnoum AB, Hickman TN, Goodman SB, Gehlbach DL, Rock JA: Incidence of symptom recurrence after hysterectomy for endometriosis. Fertil Steril 1995;64:898-902.
42. Bianchi S, Busacca M, Agnoli B: Effects of three month therapy with danazol after laparoscopic surgery for stage III-IV endometriosis: a randomized study. Hum Reprod 1999;14:1335-1337.
43. Parazzini F, Fedele L, Busacca M, et al: Postsurgical medical treatment of advanced endometriosis; results of a randomized clinical trial. Am J Obstet Gynecol 1994;171:1205-1207.
44. Hornstein MD, Hemmings R, Yuzpe AA, Heinrichs WL: Use of nafarelin versus placebo after reductive laparoscopic surgery for endometriosis. Fertil Steril 1997;68:860-864.
45. Vercellini P, Crosignani PG, Fadini R, Radici E, Belloni C, Sismondi P: A gonadotropin releasing hormone agonist compared with expectant management after conservative surgery for symptomatic endometriosis. BJOG 1999;106:672-677.
46. Muzii L, Marana L, Caruana P, et al: Postoperative administration of monophasic combined oral contraceptives after laparoscopic treatment of ovarian endometriomas: a prospective randomized trial. Am J Obstet Gynecol 2000;183:588-592.
47. Morgante G, Ditto A, La Marca A, De Leo V: Low dose danazol after combined surgical and medical therapy reduces the incidence of pelvic pain in women with moderate and severe endometriosis. Hum Reprod 1999;14:2371-2374.
48. Berube S, Marcoux S, Langevin M, Maheux R: Fecundity of infertile women with minimal or mild endometriosis and women with unexplained infertility. The Canadian Collaborative Group on Endometriosis. Fertil Steril 1998;69:1034-1041.
49. Fedele L, Bianchi S, Marchin M, Villa L, Brioschi D, Parazzini F: Superovulation with human menopausal gonadotropins in the treatment of infertility associated with minimal or mild endometriosis: a controlled randomized study. Fertil Steril 1992;58:28-31.
50. Marcoux S, Maheux R, Berube S: Laparoscopic surgery in infertile women with minimal or mild endometriosis. Canadian Collaborative Group on Endometriosis. N Engl J Med 1997;337:217-222.
51. Olive DL, Stohs GF, Metzger DA, Franklin RR: Expectant management and hydrotubations in the treatment of endometriosis-associated infertility. Fertil Steril 1985;44:35-41.
52. Hughes E, Brown J, Collins JJ, Farquhar C, Fedorkow DM, Vandekerckhove P: Ovulation supression for endometriosis. Cochrane Database Syst Rev 2007;3:CD000155.
53. Balasch J, Creus M, Fabreguez F, et al: Pentoxifylline versus placebo in the treatment of infertility associated with minimal or mild endometriosis: a pilot randomized clinical trial. Hum Reprod 1997;12:2046-2050.
54. Alborzi S, Ghotbi S, Parsanezhad ME, et al: Pentoxifylline therapy after laparoscopic surgery for different stages of endometriosis: a prospective, double-blind, randomized, placebo-controlled study. J Minimal Invasive Gynecol 2007;14:54-58.
55. Chapron C, Vercellini P, Barakat H, Vieira M, Dubuisson JB: Management of ovarian endometriomas. Hum Reprod Update 2002;8:591-597.
56. Busacca M, Bianchi M, Agnoli B, et al: Follow-up of laparoscopic treatment of stage IIIIV endometriosis. J Am Assoc Gynecol Laparosc 1999;6:55-58.
57. Soong YK, Chang FH, Chou HH, et al: Life table analysis of pregnancy rates in women with moderate or severe endometriosis comparing danazol therapy after carbon dioxide laser laparoscopy plus electrocoagulation or laparotomy plus electrocoagulation versus danazol therapy only. J Am Assoc Gynecol Laparosc 1997;4:225-230.
58. Parazzini F: Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial. Gruppo Italiano per lo Studio dell'Endometriosi. Hum Reprod 1999;14:1332-1334.
59. Olive DL: Endometriosis: does surgery make a difference? OBG Manage 2002;56-70.
60. Jacobson TZ, Barlow DH, Koninckx PR, Olive DL, Farquhar C: Laparoscopic surgery for subfertility associated with endometriosis. Cochrane Database Syst Rev 2002;CD001398.
61. Audebert A, Descamps P, Marret H, Ory-Lavollee L, Bailleul F, Hamamah S: Pre or postoperative medical treatment with nafarelin in stage III-IV endometriosis: a French multicenter study. Eur J Obstet Gynecol Reprod Biol 1998;79:145-148.
62. Donnez J, Nisolle M, Gillerot S, Anaf V, Lerckx-Braun F, Casanas-Roux F: Ovarian endometrial cysts: the role of gonadotropin-releasing hormone agonist and/or drainage. Fertil Steril 1994;62:63-66.
63. Muzii L, Marana R, Caruana P, Mancuso S: The impact of preoperative gonadotropin-releasing hormone agonist treatment on laparoscopic excision of ovarian endometriotic cysts. Fertil Steril 1996;65:1235-1237.
64. Vercellini P, Crosignani PG, Fadini R, Radici E, Belloni C, Sismondi P: A gonadotropin-releasing hormone agonist compared with expectant management after conservative surgery for symptomatic endometriosis. Br J Obstet Gynaecol 1999;106:672-677.
65. Alvarez-Gil L, Fuentes V: Raloxifene and endometriosis. Fertil Steril 2002;77:37.
66. Busacca M, Somigliana E, Bianchi S, et al: Postoperative GnRH analogue treatment after conservative surgery for symptomatic endometriosis stage III-IV: a randomized controlled trial. Hum Reprod 2001;16:2399-2402.
67. Buyalos RP, Agarwal SK: Endometriosis-associated infertility. Curr Opin Obstet Gynecol 2000;12:377-381.
68. Deaton JL, Gibson M, Blackmer KM, Nakajima ST, Badger GJ, Brumsted JR: A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis. Fertil Steril 1990;54:1083-1088.
69. Tummon IS, Asher LJ, Martin JS, Tulandi T: Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis. Fertil Steril 1997;68:8-12.
70. Chaffkin LM, Nulsen JC, Luciano AA, Metzger DA: A comparative analysis of the cycle fecundity rates associated with combined human menopausal gonadotropin (hMG) and intrauterine insemination (IUI) versus either hMG or IUI alone. Fertil Steril 1991;55:252-257.
71. Guzick DS: Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis. J Womens Health 1997;6:489-490.
72. Dmowski WP, Pry M, Ding J, Rana R: Cycle-specific and cumulative fecundity in patients with endometriosis who are undergoing controlled ovarian hyperstimulation-intrauterine insemination or in vitro fertilization-embryo transfer. Fertil Steril 2002;78:750-756.
73. Al-Azemi M, Bernal AL, Steele J, Gramsbergen I, Barlow D, Kennedy S: Ovarian response to repeated controlled stimulation in in-vitro fertilization cycles in patients with ovarian endometriosis. Hum Reprod 2000;15:72-75.
74. Tinkanen H, Kujansuu E: In vitro fertilization in patients with ovarian endometriomas. Acta Obstet Gynecol Scand 2000;79:119-122.
75. Kodama H, Fukuda J, Karube H, Matsui T, Shimizu Y, Tanaka T: Benefit of in vitro fertilization treatment for endometriosis-associated infertility. Fertil Steril 1996;66:974-979.
76. Azem F, Lessing JB, Geva E, et al: Patients with stages III and IV endometriosis have a poorer outcome of in vitro fertilization-embryo transfer than patients with tubal infertility. Fertil Steril 1999;72:1107-1109.
77. Arici A, Oral E, Bukulmez O, Duleba A, Olive DL, Jones EE: The effect of endometriosis on implantation: results from the Yale University in vitro fertilization and embryo transfer program. Fertil Steril 1996;65:603-607.
78. Barnhart K, Dunsmoor-Su R, Coutifaris C: Effect of endometriosis on in vitro fertilization. Fertil Steril 2002;77:1148-1155.
79. Matalliotakis IM, Cakmak H, Mahutte N, Fragouli Y, Arici A, Sakkas D: Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertil Steril 2007;88:1568-1572.
80. Templeton A, Morris JK, Parslow W: Factors that affect outcome of in-vitro fertilization treatment. Lancet 1996;348:1402-1406.
81. Bukulmez O, Yarali H, Gurgan T: The presence and extent of endometriosis do not effect clinical pregnancy and implantation rates in patients undergoing intracytoplasmic sperm injection. Eur J Obstet Gynecol Reprod Biol 2001;96:102-107.
82. Surrey ES, Silverberg KM, Surrey MW, Schoolcraft WB: Effect of prolonged gonadotropin-releasing hormone agonist therapy on the outcome of in vitro fertilization-embryo transfer in patients with endometriosis. Fertil Steril 2002;78:699-704.
83. Olivennes F, Feldberg D, Liu HC, Cohen J, Moy F, Rosenwaks Z: Endometriosis: a stage by stage analysis: the role of in vitro fertilization. Fertil Steril 1995;64:392-398.