Transfusion-related immunomodulation: A second hit in an inflammatory cascade?

Vox Sanguinis

Volumn 95, Issue 4, 2008, Pages 261-271

  Bilgin, Y M ^a,b   Brand, A ^b  

^a Sanquin Bloedbank Regio Zuidwest Rotterdam   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cardiac surgery; Leucodepletion; Red blood cell transfusions; Transfusion related immunomodulation

Indexed keywords

BACTERIAL INFECTION; BLOOD TRANSFUSION; CARDIOPULMONARY BYPASS; COLORECTAL SURGERY; ERYTHROCYTE; HEALTH CARE POLICY; HEART SURGERY; HUMAN; IMMUNOMODULATION; INFLAMMATION; LEUKOCYTE TRANSFUSION; MORTALITY; NONHUMAN; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; TUMOR IMMUNITY;

CARDIAC SURGICAL PROCEDURES; ERYTHROCYTE TRANSFUSION; HUMANS; INFLAMMATION; LEUKOCYTE REDUCTION PROCEDURES; LEUKOCYTES; POSTOPERATIVE COMPLICATIONS;

EID: 53849138041     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/j.1423-0410.2008.01100.x     Document Type: Review

References (72)

1. Opelz G, Sengar DDS, Mickey MR, Terasaki PI : Effect of blood transfusions on subsequent kidney transplants. Transplant Proc 1971 5 : 253 259
2. Vamvakas EC, Blajchman MA : Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction? Blood 2001 97 : 1180 1195
3. Vamvakas EC : White-blood-cell-containing allogeneic blood transfusion and postoperative infection or mortality: an updated meta-analysis. Vox Sang 2007 92 : 224 232
4. Blumberg N, Zhao H, Wang H, Messing S, Heal JM, Lyman GH : The intention-to-treat principle in clinical trials and meta-analyses of leukoreduced blood transfusions in surgical patients. Transfusion 2007 47 : 573 581
5. Moher D, Tsertsvadse A : Systematic reviews: when is an update an update? Lancet 2006 367 : 881 883
6. Carson JL, Hill S, Carless P, Hébert P, Henry D : Transfusion triggers: a systematic review of the literature. Transfus Med Rev 2002 16 : 187 199.
7. Lacroix J, Hébert PC, Hutchison JS, Hume HA, Tucci M, Ducruet T, Gauvin F, Collet J-P, Toledano BJ, Robillard P, Joffe A, Biarent D, Meert K, Peters MJ : Transfusion strategies for patients in pediatric intensive care units. New Engl J Med 2007 356 : 1609 1619
8. Jonas RA, Wypij D, Roth SJ, Bellinger DC, Visconti KJ, du Plessis AJ, Goodkin H, Laussen PC, Farrell DM, Bartlett J, McGrath E, Rappaport LJ, Bacha EA, Forbess JM, del Nido PJ, Mayer JE, Newburger JW : The influence of hemodilution on outcome after hypothermic cardiopulmonary bypass: results of a randomized trial in infants. J Thorac Cardiovasc Surg 2003 126 : 1765 1774
9. Bell EF, Strauss RG, Widness JA, Mahoney LT, Mock DM, Seward VJ, Cress GA, Johnson KJ, Kromer IJ, Zimmerman MB : Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. Pediatrics 2005 115 : 1685 1691
10. Kirpalani H, Whyte RK, Andersen C, Asztalos EV, Heddle N, Blajchman MA, Peliowski A, Rios A, LaCorte M, Connelly R, Barrington K, Roberts RS : The premature infants in need of transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr 2006 149 : 301 307
11. Jensen LS, Andersen AJ, Christiansen PM, Hokland P, Juhl CO, Madsen G, Mortensen J, Moller-Nielsen C, Hanberg-Sorensen F, Hokland M : Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery. Br J Surg 1992 79 : 513 516
12. Houbiers JG, Brand A, van de Watering LM, Hermans J, Verwey PJ, Bijnen AB, Pahlplatz P, Eeftinck Schattenkerk M, Wobbes T, de Vries JE : Randomized controlled trial comparing transfusion of leucocyte-depleted or buffy-coat-depleted blood in surgery for colorectal cancer. Lancet 1994 344 : 573 578
13. Jensen LS, Kissmeyer-Nielsen P, Wolff B, Qvist N : Randomized comparison of leucocyte-depleted versus buffy-coat-poor blood transfusion and complications after colorectal surgey. Lancet 1996 348 : 841 845
14. Tartter P, Mohandes K, Azar P, Endres J, Kaplan J, Spivack M : Randomized trial comparing packed red blood cell transfusion with and without leukocyte depletion for gastrointestinal surgey. Am J Surg 1998 176 : 462 466
15. Titlestad IL, Ebbesen LS, Ainsworth AP, Lillevang ST, Qvist N, Georgsen J : Leukocyte-depletion of blood components does not significantly reduce the risk of infectious complications. Results of a double-blinded, randomized study. Int J Colorectal Dis 2001 16 : 147 153
16. van Hilten JA, van de Watering LMG, van de Velde CHJ, Kievit J, Brand R, van den Hout WB, Geelkerken RH, Roumen RMH, Wesselink RMJ, Koopman-van Gemert AWMM, Koning J, Brand A : Effects of transfusion with red cells filtered to remove leukocytes: randomised controlled trial in patients undergoing major surgery. BMJ 2004 328 : 1281 1284
17. Skanberg J, Lundholm K, Haglind H : Effects of blood transfusion with leucocyte depletion on length of hospital stay, respiratory assistance and survival after curative surgery for colorectal cancer. Acta Oncol 2007 46 : 1123 1130
18. Nathens AB, Nester TA, Rubenfeld GD, Nirula R, Gernsheimer TB : The effects of leukoreduced blood transfusion on infection risk following injury: a randomized controlled trial. Shock 2006 26 : 342 347
19. van de Watering LM, Hermans J, Houbiers JG, van den Broek PJ, Bouter H, Boer F, Harvey MS, Huysmans HA, Brand A : Beneficial effects of leukocyte depletion of transfused blood on postoperative complications in patients undergoing cardiac surgery: a randomized clinical trial. Circulation 1998 97 : 562 568
20. Bracey AW, Radovancevic R, Nussmeier NA, Houston S, LaRocco M, Vaughn WK, Cooper JR : Leukocyte-reduced blood in open heart surgery patients: effects on outcome. Transfusion 2002 42 (Suppl 5S (Abstract)
21. Wallis JP, Chapman CE, Orr KE, Clark SC, Forty JR : Effect of WBC reduction of transfused RBCs on postoperative infection rates in cardiac surgery. Transfusion 2002 42 : 1127 1134
22. Bilgin YM, van de Watering LM, Eijsman L, Versteegh MIM, Brand R, van Oers MHJ, Brand A : Double-blind, randomized controlled trial on the effect of leukocyte-depleted erythrocyte transfusions in cardiac valve surgery. Circulation 2004 109 : 2755 2760
23. Connery CP, Toumpoulis IK, Anagnostopoulis CE, Hillei Z, Rahman FG, Katritsis D, Swistel DG : Does leukofiltration reduce pulmonary infections in CABG patients? A prospective, randomized study with early results and mid-term survival. Acta Cardiol 2005 60 : 285 293
24. Boshkov LK, Chien G, VanWinkle D, Furnary AP, Wu Y, Grunkemeirer GL, Morris CD : Prestorage leukoreduction of transfused packed red cells is associated with significant ongoing 2-12 month survival benefit cardiac surgery patients. Blood 2006 108 : 578 (Abstract)
25. Dzik WH, Anderson JK, O'Neill EM, Assman SF, Kalish LA, Stowell CP : A prospective randomized clinical trial of universal leukoreduction. Transfusion 2002 42 : 1114 1122
26. Collier AC, Kalish LA, Busch MP, Gernsheimer T, Assmann SF, Lane TA, Asmuth DM, Lederman MM, Murphy EL, Kumar P, Kelley M, Flanigan TP, McMahon DK, Sacks HS, Kennedy MS, Holland PV : Leukocyte-reduced red blood cell transfusions in patients with anemia and human immunodeficiency virus infection - the viral activation transfusion study: a randomized controlled trial. JAMA 2001 285 : 1592 1601
27. Sanfilippo FP, Bollinger RR, Macquin JM, Brooks BJ, Koepke JA : A randomized study comparing leukocyte-depleted versus packed red cell transfusions in prospective cadaver renal allograft recipients. Transfusion 1985 25 : 116 119
28. Opelz G, Vanrenterghem Y, Kirste G, Gray DWR, Horsburgh T, Lachance JG, Larglader F, Lange H, Vujaklija-Stipanovic P, Descoeudres C, Ruder H, Wujciak T, Schwarz V : Prospective evaluation of pretransplant blood transfusions in cadaver kidney recipients. Transplantation 1997 63 : 964 967
29. Hiesse C, Busson M, Buisson C, Farahmand H, Bierling P, Benbunan M, Bendrossian J, Aubert P, Glotz D, Loirat C, Rondeau E, Viron B, Bleux H, Lang P : Multicenter trial of one HLA-DR matched or mismatched blood transfusion prior to cadaveric renal transplantation. Kidney Int 2001 60 : 341 349
30. Hébert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E the Canadian TRIC investigators : A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. New Engl J Med 1999 340 : 409 417
31. van de Watering LMG, Brand A, Houbiers JGA, Klein Kranenbarg WM, Hermans J, van de Velde CHJ : Perioperative blood transfusions, with or without allogeneic leucocytes, relate to survival, not to cancer recurrence. Br J Surg 2001 88 : 267 272
32. Momburg F, Degener T, Bacchus E, Moldenhauer G, Hammerling GJ, Moller P : Loss of HLA-ABC and de novo expression of HLA-D in colorectal cancer. Int J Cancer 1986 37 : 179 184
33. Watkins TR, Rubenfeld GD, Martin TR, Nester TA, Caldwell E, Billgren J, Ruzinski J, Nathens AB : Effects of leukoreduced blood on acute lung injury after trauma: a randomized controlled trial. Crit Care Med 2008 36 : 1493 1499
34. Vamvakas EC : Why have meta-analyses of randomized controlled trials of the association between non-white-blood-cell-reduced allogeneic blood transfusion and postoperative infection produced discordant results? Vox Sang 2007 93 : 196 207
35. Karkouti K, Wijeysundera DN, Yau TM, Beattle WS, Abelnaem E, McCluskey SA, Ghannam M, Djaiani G, Karski J : The independent association of massive blood loss with mortality in cardiac surgery. Transfusion 2004 44 : 1453 1462
36. Murphy GJ, Reeves BC, Rogers CA, Rizvi SIA, Culliford L, Angelini GD : Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. Circulation 2007 116 : 2544 2552
37. Spiess RD, Royston D, Levy JH, Fitch J, Dietrich W, Body S, Murkin J, Nadel A : Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse events. Transfusion 2004 46 : 1143 1146
38. Bilgin YM, van de Watering LMG, Eijsman L, Versteegh MIM, van Oers MHJ, Brand A : Is increased mortality associated with postoperative infections after leukocytes containing red blood cell transfusions in cardiac surgery? An extended analysis. Transf Med 2007 17 : 304 311
39. Jensen LS, Puho E, Pedersen L, Mortensen FV, Sorensen HF : Long-term survival after colorectal surgery associated with buffy-coat-poor and leucocyte-depleted blood transfusion: a follow-up study. Lancet 2005 365 : 681 682
40. Koch GC, Li L, Sessler DI, Figueroa P, Hoeltge GA, Mihaljevic T, Blackstone EH : Duration of red-cell storage and complications after cardiac surgery. New Engl J Med 2008 358 : 1229 1239
41. Benjamin RJ, Dodd RY : Red-cell storage and complications of cardiac surgery. New Engl J Med 2008 358 : 2840 2841
42. Vamvakas EC, Carven JH : Transfusion and postoperative pneumonia in coronary artery bypass graft surgery: effect of the length of storage of transfused red cells. Transfusion 1999 39 : 701 710
43. Leal-Noval SR, Jara-Lopez I, Garcia-Garmendia JL, Marin-Niebla A, Herruzo-Aviles A, Camacho-Larana P, Loscertales J : Influence of erythrocyte concentrate storage time on postsurgical morbidity in cardiac surgery patients. Anesthesiology 2003 98 : 815 822
44. Hébert PC, Chin-Yee I, Fergusson D, Blachjman M, Martineau R, Clinch J, Olberg B : A pilot trial evaluating the clinical effects of prolonged storage of red cells. Anesth Analg 2005 100 : 1433 1438
45. van de Watering L, Lorinser J, Versteegh M, Westendord R, Brand A : Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients. Transfusion 2006 46 : 1712 1718
46. Basran S, Frumento RJ, Cohen A, Lee S, Du Y, Nishanian Kaplan HS, Stafford-Smith M, Bennett-Guerrero E : The association between duration of storage of transfused red blood cells and morbidity and mortality after reoperative cardiac surgery. Anesth Analg 2006 103 : 15 20
47. Lagaaij EL, Henneman IP, Ruigrok M, de Haan MW, Persijn GG, Termijtelen A, Hendricks GF, Weimar W, Claas FH, van Rood JJ : Effect of one-HLA-DR antigen-matched and completely HLA-DR-mismatched blood transfusions on survival of heart and kidney allografts. New Engl J Med 1989 321 : 701 705
48. Muylle L : The role of cytokines in blood transfusion reactions. Blood Rev 1995 9 : 77 83
49. Escobar GA, Cheng AM, Moore EE, Johnson JL, Tannahill C, Baker HV, Moldawer LL, Banerjee A : Stored packed red blood cell transfusion up-regulates inflammatory gene expression in circulating leukocytes. Ann Surg 2007 246 : 129 134
50. Ottonello L, Ghio M, Contini P, Bertolotto M, Bianchi G, Montecucco F, Colonna M, Mazzei C, Dallegri F, Indiveri F : Nonleukoreduced red blood cell transfusion induces a sustained inhibition of neutrophil chemotaxis by stimulating in vivo production of transforming growth factor-β1 by neutrophils: role of the immunoglobulin-like transcript 1, sFasL, and sHLA-I. Transfusion 2007 47 : 1395 1404
51. Izbicki G, Rudensky B, Na'amad M, Herschko C, Huerta M, Hersch M : Transfusion-related leukocytosis in critically ill patients. Crit Care Med 2004 32 : 439 442
52. Heddle NM, Klama LN, Griffith GR, Shukla G, Kelton JG : A prospective study to identify the risk factors associated with acute reactions to platelet and red cell transfusions. Transfusion 1993 33 : 794 797
53. Dzik WH, Mincheff M, Puppo F : An alternative mechanism for the immunosuppressive effect of transfusion. Vox Sang 2002 83 (Suppl. 1 417 419
54. Chang H, Voralia H, Bali M, Sher GD, Branch DR : Irreversible loss of donor blood leukocyte activation may explain a paucity of transfusion-associated graft-versus-host disease from stored blood. Br J Haematol 2000 111 : 146 156
55. Mincheff MS, Meryman HT, Kapoor V, Alsop P, Wotzel M : Blood transfusion and immunomodulation: a possible mechanism. Vox Sang 1993 65 : 18 24
56. Schechter GP, Whang-Peng J, McFarland W : Circulation of donor lymphocytes after blood transfusion in man. Blood 1977 49 : 651 656
57. Lee TH, Paglieroni T, Ohto H, Holland PV, Busch MP : Survival of donor leukocyte subpopulations in immunocompetent transfusion recipients: frequent long-term microchimerism in severe trauma patients. Blood 1999 93 : 3127 3139
58. Utter GH, Nathens AB, Lee T-H, Reed WF, Owings JT, Nester TA, Busch MP : Leukoreduction of blood transfusions does not diminish transfusion-associated microchimerism in trauma patients. Transfusion 2006 46 : 1863 1869
59. Caetano Reis e Sousa : Toll-like receptors and dendritic cells: for whom the bug tolls. Semin Immunol 2004 16 : 27 34
60. Johnson GB, Brunn GJ, Samstein JL, Platt B : New insight into the pathogenesis of sepsis and the sepsis syndrome. Surgery 2005 137 : 393 395
61. Hoesel LM, Niederbichler AD, Schaefer J, Ipaktchi KR, Gao H, Rittirsch D, Pianko MJ, Vogt PM, Sarma JV, Su GL, Arbabi S, Westfall MV, Wang SC, Hemmila MR, Ward PA : C5a-Blockade improves burn-induced cardiac dysfunction. J Immunol 2007 178 : 7902 7910
62. Bone RC : Sepsis, SIRS and CARS. Crit Care Med 1996 24 : 1125 1128
63. Singer M, De Santis V, Vitale D, Jeffcoate W : Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet 2004 364 : 545 548
64. Ertel W, Keel M, Neidthardt R, Steckholzer U, Kremer JP, Ungethuem U, Trentz O : Inhibition of the defense system stimulating interleukin-12 interferon-gamma pathway during critical illness. Blood 1997 89 : 1612 1620
65. Decker P, Schöndorf M, Bidlingmaier F, Hirner A, von Ruecker AA : Surgical stress induces a shift in the type 1/type 2 T helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma. Surgery 1996 119 : 316 325
66. Guidet B, Aegerter P, Gauzit R, Meshaka P, Dreyfuss D : Incidence and impact of organ dysfunctions associated with sepsis. Chest 2005 127 : 942 951
67. Sablotzki A, Dehne MG, Welters I, Menges T, Lehman N : Alterations of the cytokine network in patients undergoing cardiopulmonary bypass. Perfusion 1997 12 : 393 403
68. Hadley JS, Wang JE, Michaels LC, Dempsey CA, Foster SJ, Thiemermann C, Hinds CJ : Alteration in inflammatory capacity and TLR expression on monocytes and neutrophils after cardiopulmonary bypass. Shock 2007 27 : 466 473
69. Yadavalli GK, Chien JW, Wener KM, Devecchio JL, Gupta S, Salata RA, Lee JH, Caldeira C, Auletta JJ, Heinzel FP : Interleukin 12 and interferon-gamma synthetic deficiency is associated with dendritic cell cytopenia after cardiac surgery. Shock 2005 24 : 26 33
70. Kissel K, Berber S, Nockher A, Santoso S, Bein G, Hackstein H : Human platelets target dendritic cell differentiation and production of proinflammatory cytokines. Transfusion 2006 46 : 818 827
71. Fransen E, Maessen J, Dentener M, Senden N, Buurman W : Impact of blood transfusions on inflammatory mediator release in patients undergoing cardiac surgery. Chest 1999 116 : 1233 1239
72. Sablotzki A, Dehne MG, Friedrich I, Grond S, Zickmann B, Muhling J, Silber RE, Czeslik EG : Different expression of cytokines in survivors and non-survivors from MODS following cardiovascular surgery. Eur J Med Res 2003 8 : 71 76