Management of chronic hepatitis B virus infection: A promising approach using small interfering RNA (siRNA)

National Medical Journal of India

Volumn 21, Issue 3, 2008, Pages 123-127

  Dwivedi, Manisha ^a   Misra, S P ^a   Misra, Vatsala ^a   Waikhom, R K ^a   Bhatnagar, Mukti ^a  

^a UNIVERSITY OF ALLAHABAD   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; DOUBLE STRANDED RNA; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; INTERFERON; LAMIVUDINE; NAKED DNA; PLASMID VECTOR; PROTEIN KINASE R; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR;

ANTIVIRAL ACTIVITY; CYTOTOXIC T LYMPHOCYTE; DRUG EFFICACY; GENE REPRESSION; GENE SILENCING; HEPATITIS B; HUMAN; IMMUNE RESPONSE; IMMUNOSTIMULATION; NONHUMAN; REVIEW; RNA INTERFERENCE; RNA STABILITY; RNA VECTOR; VIRAL GENE DELIVERY SYSTEM; VIRUS REPLICATION;

GENE SILENCING; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEPATITIS B, CHRONIC; HUMANS; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING;

EID: 53849108462     PISSN: 0970258X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (36)

1. Kao JH, Chen DS. Global control of hepatitis B virus infection. Lancet Infect Dis 2002;2:395-403.
2. Cooksley WG. Treatment with interferons (including pegylated interferons) in patients with hepatitis B. Semin Liver Dis 2004; 24 (Suppl 1):45-53.
3. Liaw YF, Leung NW, Chang TT, Guan R, Tai DI, Ng KY, et al. Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B: Asia Hepatitis Lamivudine Study Group. Gastroenterology 2000; 119:172-80.
4. Suzuki F, Suzuki Y, Tsubota A, Akuta N, Someya T, Kobayashi M, et al. Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy. J Hepatol 2002;37:824-30.
5. Marcellin P. Advances in therapy for chronic hepatitis B. Semin Liver Dis 2002;22 (Suppl 1):33-6.
6. Lai CL, Rosmawati M, Lao J, Van Vlierberghe H, Anderson FH, Thomas N, et al. Entecavir is superior to lamivudine in reducing hepatitis B virus DNA in patients with chronic hepatitis B infection. Gastroenterology 2002;123:1831-8.
7. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391:806-11.
8. Bernstein E, Caudy AA, Hammond SM, Hannon GJ. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 2001;409:363-6.
9. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-8.
10. Coburn GA, Cullen BR. Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference. J Virol 2002;76:9225-31.
11. Jacque JM, Triques K, Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature 2002;418:435-8.
12. Gitlin L, Karelsky S, Andino R. Short interfering RNA confers intracellular antiviral immunity in human cells. Nature 2002; 418:430-4.
13. Jiang M, Milner J. Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA. A primer of RNA interference. Oncogene 2002;21:6041-8.
14. Bitko V, Barik S. Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses. BMC Microbiol 2001;1:34.
15. Ge Q, McManus MT, Nguyen T, Shen CH, Sharp PA, Eisen HN, et al. RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc Natl Acad Sci USA 2003;100:2715-23.
16. Adelman ZN, Sanchez-Vargas I, Travanty EA, Carlson JO, Beaty BJ, Blair CD, et al. RNA silencing of dengue virus type 2 replication in transformed C6/36 mosquito cells transcribing an inverted-repeat RNA derived from the virus genome. J Virol 2002;76:12925-33.
17. Balachandran S, Roberts PC, Brown LE, Truong H, Pattnaik AK, Archer DR. et al. Essential role for the dsRNA-dependent protein kinase PKR in innate immunity, to viral infection. Immunity 2000; 13:129-141.
18. Hunter T, Hunt T, Jackson RJ, Robertson HD. The characteristics of inhibition of protein synthesis by double-stranded ribonucleic acid in reticulocyte lysates. J Biol Chem 1975;250:409-17.
19. Shlomai A, Shaul Y. Inhibition of hepatitis B virus expression and replication by RNA interference. Hepatology 2003;37:764-70.
20. Chen Y, Du D, Wu J, Chan CP, Tan Y, Kung HF, et al. Inhibition of hepatitis B virus replication by stably expressed shRNA. Biochem Biophys Res Commun 2003;311:398-404.
21. Ren X, Luo G, Xie Z, Zhou L, Kong X, Xu A. Inhibition of multiple gene expression and virus replication of HBV by stable RNA interference in 2.2.15 cells. J Hepatol 2006;44:663-70.
22. Konishi M, Wu CH, Wu GY. Inhibition of HBV replication by siRNA in a stable HBV-producing cell line. Hepatology 2003; 38:842-50.
23. Hamasaki K, Nakao K, Matsumoto K, Ichikawa T, Ishikawa H, Eguchi K. Short interfering RNA-directed inhibition of hepatitis B virus replication. FEBS Lett 2003;543:51-4.
24. Ying C, De Clercq E, Neyts J. Selective inhibition of hepatitis B virus replication by RNA interference. Biochem Biophys Res Commun 2003;309:482-4.
25. Klein C, Bock CT, Wedemeyer H, Wustefeld T, Locarnini S, Dienes HP. et al. Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA. Gastroenterology 2003; 125:9-18.
26. McCaffrey AP, Nakai H, Pandey K, Huang Z, Salazar PH, Xu H, et al. Inhibition of hepatitis B virus in mice by RNA interference. Nat Biotechnol 2003;21:639-44.
27. Giladi H, Ketzinel-Gilad M, Rivkin L, Felig Y, Nussbaum O, Galun E. Small interfering RNA inhibits hepatitis B virus replication in mice. Mol Ther 2003;8:769-76.
28. Uprichard SL, Boyd B, Althage A, Chisari FV. Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs. Proc Natl Acad Sci USA 2005;102:773-8.
29. Zhe C, Zex X, Peng, Jia YJ, Yao Ping YH, Shu Z, et al. Combination of small interfering RNAs mediate greater inhibition on human hepatitis B replication and antigen expression. J Zhejiang University Science 2005;4:236-41.
30. Li GQ, Xu WZ, Wang JX, Deng WW, Li D, Gu HX. Combination of small interfering RNA and lamivudine on inhibition of human B virus replication in HepG2.2.15 cells. World J Gastroenterol 2007; 13:2324-7.
31. Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 2002; 296:550-3.
32. Bridge AJ, Pebernard S, Ducraux A, Nicoulaz AL, Iggo R. Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet 2003;34:263-4.
33. Sledz CA, Holko M, de Veer MJ, Silverman RH, Williams BR. Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 2003;5:834-9.
34. Jackson AL, Bartz SR, Schelter J, Kobayashi SV, Burchard J, Mao M, et al. Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 2003;21:635-7.
35. Haasnoot PC, Bol JF, Olsthoorn RC. A plant virus replication system to assay the formation of RNA pseudotriloop motifs in RNA-protein interactions. Proc Natl Acad Sci USA 2003;100:12596-600.
36. Shin D, Kim SI, Kim M, Park M. Efficient inhibition of hepatitis B virus replication by small interfering RNAs targeted to the viral X gene in mice. Virus Res 2006;119:146-53.