Troglitazone thiol adduct formation in human liver microsomes: Enzyme kinetics and reaction phenotyping

Drug Metabolism Letters

Volumn 2, Issue 3, 2008, Pages 184-189

  Gan, Jinping ^a   Qu, Qinling ^a   He, Bing ^a   Shyu, Wen C ^a   Rodrigues, A David ^a   He, Kan ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

CYP2C8; CYP3A4; Reaction phenotyping; Reactive metabolite; Troglitazone

Indexed keywords

CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 INHIBITOR; DRUG METABOLITE; FURAFYLLINE; GLUTATHIONE; KETOCONAZOLE; MONTELUKAST; N BENZYLNIRVANOL; QUINIDINE; SULFAPHENAZOLE; THIOL; TROGLITAZONE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG COMPETITION; DRUG INHIBITION; ENZYME KINETICS; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; LIVER MICROSOME; LIVER TOXICITY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ARYL HYDROCARBON HYDROXYLASES; CHROMANS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DANSYL COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE; HUMANS; HYPOGLYCEMIC AGENTS; MICROSOMES, LIVER; PHENOTYPE; SULFHYDRYL COMPOUNDS; THIAZOLIDINEDIONES;

EID: 53749089107     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231208785425773     Document Type: Article

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