Cellular magnetic resonance imaging: Potential for use in assessing aspects of cardiovascular disease

Cytotherapy

Volumn 10, Issue 6, 2008, Pages 575-586

  Zhang, Z ^a   Mascheri, N ^a,b   Dharmakumar, R ^a   Li, Debiao ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Northwestern University   (United States)

Author keywords

Atherosclerotic plaque; Cellular MRI; Myocardial regeneration; Superparamagnetic iron oxide nanoparticle

Indexed keywords

FERUCARBOTRAN; FERUMOXTRAN 10; FERUMOXYTOL; SUPERPARAMAGNETIC IRON OXIDE; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG;

ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CELL LABELING; CELL MIGRATION; CELL TRANSPLANTATION; CONCENTRATION (PARAMETERS); CONTRAST ENHANCEMENT; HEART FAILURE; HEART MUSCLE; HUMAN; IMAGE ANALYSIS; IN VIVO STUDY; MACROPHAGE; MUSCLE REGENERATION; NON INVASIVE MEASUREMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RABBIT; REVIEW; SENSITIVITY ANALYSIS; STEM CELL; STEM CELL TRANSPLANTATION; THREE DIMENSIONAL IMAGING;

EID: 53749086095     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1080/14653240802165699     Document Type: Article

References (72)

1. Bulte, JW and Kraitchman, DL. (2004) Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed, 17, pp. 484-499.
2. Idee, JM, Port, M. Raynal, I. et al. (2006) Clinical and biological consequences of transmetallation induced by contrast agents for magnetic resonance imaging: A review. Fundam Clin Pharmacol, 20, pp. 563-576.
3. Limanond, P., Raman, SS, Sayre, J. and Lu, DS. (2004) Comparison of dynamic gadolinium-enhanced and ferumoxides-enhanced MRI of the liver on high- and low-field scanners. J Magn Reson Imaging, 20, pp. 640-647.
4. Frank, JA, Anderson, SA Kalsih, H. et al. (2004) Methods for magnetically labeling stem and other cells for detection by in vivo magnetic resonance imaging. Cytotherapy, 6, pp. 621-625.
5. Modo, M., Hoehn, M. and Bulte, JW. (2005) Cellular MR imaging. Mol Imaging, 4, pp. 143-164.
6. Thorek, DL, Chen, AK, Czupryna, J. and Tsourkas, A. (2006) Superparamagnetic iron oxide nanoparticle probes for molecular imaging. Ann Biomed Eng, 34, pp. 23-38.
7. Bowen, CV, Zhang, X. Saab, G. et al. (2002) Application of the static dephasing regime theory to superparamagnetic iron-oxide loaded cells. Magn Reson Med, 48, pp. 52-61.
8. Politi, LS. (2007) MR-based imaging of neural stem cells. Neuroradiology, 49, pp. 523-534.
9. Daldrup-Link, HE, Rudelius, M. Piontek, G. et al. (2005) Migration of iron oxide-labeled human hematopoietic progenitor cells in a mouse model: In vivo monitoring with 1. 5-T MR imaging equipment. Radiology, 234, pp. 197-205.
10. Kraitchman, DL, Heldman, AW Atalar, E. et al. (2003) In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction. Circulation, 107, pp. 2290-2293.
11. Garot, J., Unterseeh, T. Teiger, E. et al. (2003) Magnetic resonance imaging of targeted catheter-based implantation of myogenic precursor cells into infarcted left ventricular myocardium. J Am Coll Cardiol, 41, pp. 1841-1846.
12. Yuan, C., Kerwin, WS Yarnykh, VL et al. (2006) MRI of atherosclerosis in clinical trials. NMR Biomed, 19, pp. 636-654.
13. Adame, IM, de Koning, PJ Lelieveldt, BP et al. (2006) An integrated automated analysis method for quantifying vessel stenosis and plaque burden from carotid MRI images: Combined postprocessing of MRA and vessel wall MR. Stroke, 37, pp. 2162-2164.
14. Amirbekian, V., Lipinski, MJ Briley-Saebo, KC et al. (2007) Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI. Proc Natl Acad Sci USA, 104, pp. 961-966.
15. Rogers, WJ and Basu, P. (2005) Factors regulating macrophage endocytosis of nanoparticles: Implications for targeted magnetic resonance plaque imaging. Atherosclerosis, 178, pp. 67-73.
16. Jung, CW and Jacobs, P. (1995) Physical and chemical properties of superparamagnetic iron oxide MR contrast agents: Ferumoxides, ferumoxtran, ferumoxsil. Magn Reson Imaging, 13, pp. 661-674.
17. Tang, TY, Howarth, SP Li, ZY et al. (2008) Correlation of carotid atheromatous plaque inflammation with biomechanical stress: Utility of USPIO enhanced MR imaging and finite element analysis. Atherosclerosis, 196, pp. 879-887.
18. Kustermann, E., Roell, W. Breitbach, M. et al. (2005) Stem cell implantation in ischemic mouse heart: A high-resolution magnetic resonance imaging investigation. NMR Biomed, 18, pp. 362-370.
19. Arbab, AS, Bashaw, LA Miller, BR et al. (2003) Intracytoplasmic tagging of cells with ferumoxides and transfection agent for cellular magnetic resonance imaging after cell transplantation: Methods and techniques. Transplantation, 76, pp. 1123-1130.
20. Ahrens, ET, Feili-Hariri, M. Xu, H. et al. (2003) Receptor-mediated endocytosis of iron-oxide particles provides efficient labeling of dendritic cells for in vivo MR imaging. Magn Reson Med, 49, pp. 1006-1013.
21. Song, M., Moon, WK Kim, Y. et al. (2007) Labeling efficacy of superparamagnetic iron oxide nanoparticles to human neural stem cells: comparison of ferumoxides, monocrystalline iron oxide, cross-linked iron oxide (CLIO)-NH2 and tat-CLIO. Korean J Radiol, 8, pp. 365-371.
22. Hill, JM, Dick, AJ Raman, VK et al. (2003) Serial cardiac magnetic resonance imaging of injected mesenchymal stem cells. Circulation, 108, pp. 1009-1014.
23. Smirnov, P., Lavergne, E. Gazeau, F. et al. (2006) In vivo cellular imaging of lymphocyte trafficking by MRI: A tumor model approach to cell-based anticancer therapy. Magn Reson Med, 56, pp. 498-508.
24. Cahill, KS, Gaidosh, G. Huard, J. et al. (2004) Noninvasive monitoring and tracking of muscle stem cell transplants. Transplantation, 78, pp. 1626-1633.
25. Sun, R., Dittrich, J. Le-Huu, M. et al. (2005) Physical and biological characterization of superparamagnetic iron oxide- and ultrasmall superparamagnetic iron oxide-labeled cells: A comparison. Invest Radiol, 40, pp. 504-513.
26. Gupta, AK, Naregalkar, RR, Vaidya, VD and Gupta, M. (2007) Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications. Nanomed, 2, pp. 23-39.
27. Kooi, ME, Cappendijk, VC Cleutjens, KB et al. (2003) Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging. Circulation; 107, 20, pp. 2453-2458.
28. Trivedi, RA, Mallawarachi, C. U-King-Im, J. et al. (2006) Identifying inflamed carotid plaques using in vivo USPIO-enhanced MR imaging to label plaque macrophages. Arterioscler Thromb Vasc Biol, 26, pp. 1601-1606.
29. Matuszewski, L., Tombach, B., Heindel, W. and Bremer, C. (2007) Molecular and parametric imaging with iron oxides. Radiologe, 47, pp. 34-42.
30. Bulte, JW, Douglas, T. Witwer, B. et al. (2001) Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol, 19, pp. 1141-1147.
31. Cunningham, CH, Arai, T. Yang, PC et al. (2005) Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles. Magn Reson Med, 53, pp. 999-1005.
32. Mani, V., Briley-Saebo, KC Itskovich, VV et al. (2006) Gradient echo acquisition for superparamagnetic particles with positive contrast (GRASP): Sequence characterization in membrane and glass superparamagnetic iron oxide phantoms at 1.5T and 3T. Magn Reson Med, 55, pp. 125-126.
33. Mauriello, A., Sangiorgi, G. Fratoni, S. et al. (2005) Diffuse and active inflammation occurs in both vulnerable and stable plaques of the entire coronary tree: A histopathologic study of patients dying of acute myocardial infarction. J Am Coll Cardiol, 1745, pp. 1585-1593.
34. Landmesser, U. and Drexler, H. (2005) Chronic heart failure: An overview of conventional treatment versus novel approaches. Nat Clin Pract Cardiovasc Med, 2, pp. 628-668.
35. Stoll, G. and Bendszus, M. (2006) Inflammation and atherosclerosis: novel insights into plaque formation and destabilization. Stroke, 37, pp. 1923-1932.
36. Antohe, F. (2006) Endothelial cells and macrophages, partners in atherosclerotic plaque progression. Arch Physiol Biochem, 112, pp. 245-253.
37. Virmani, R., Kolodgie, FD Burke, AP et al. (2005) Atherosclerotic plaque progression and vulnerability to rupture: Angiogenesis as a source of intraplaque hemorrhage. Arterioscler Thromb Vasc Biol, 25, pp. 2054-2061.
38. Lim, WS, Timmins, JM Seimon, TA et al. (2008) Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo. Circulation, 117, pp. 940-951.
39. Briley-Saebo, KC, Mulder, WJ Mani, V. et al. (2007) Magnetic resonance imaging of vulnerable atherosclerotic plaques: Current imaging strategies and molecular imaging probes. J Magn Reson Imaging, 26, pp. 460-479.
40. Schmitz, SA, Taupitz, M. Wagner, S. et al. (2001) Magnetic resonance imaging of atherosclerotic plaques using superparamagnetic iron oxide particles. J Magn Reson Imaging, 14, pp. 355-361.
41. Ruehm, SG, Corot, C. Vogt, P. et al. (2001) Magnetic resonance imaging of atherosclerotic plaque with ultrasmall superparamagnetic particles of iron oxide in hyperlipidemic rabbits. Circulation, 103, pp. 415-422.
42. Herborn, CU, Vogt, FM Lauenstein, TC et al. (2006) Magnetic resonance imaging of experimental atherosclerotic plaque: Comparison of two ultrasmall superparamagnetic particles of iron oxide. J Magn Reson Imaging, 24, pp. 388-393.
43. Schmitz, SA, Coupland, SE Gust, R. et al. (2000) Superparamagnetic iron oxide-enhanced MRI of atherosclerotic plaques in Watanabe hereditable hyperlipidemic rabbits. Invest Radiol, 35, pp. 460-471.
44. Yancy, AD, Olzinski, AR Hu, TC et al. (2005) Differential uptake of Ferumoxtran-10 and Ferumoxytol, ultrasmall superparamagnetic iron oxide contrast agents in rabbit: Critical determinants of atherosclerotic plaque labeling. J Magn Reson Imaging, 21, pp. 432-442.
45. Priest, AN, Ittrich, H. Jahntz, C. et al. (2006) Investigation of atherosclerotic plaques with MRI at 3T using ultrasmall superparamagnetic particles of iron oxide. MRI, 24, pp. 1287-1293.
46. Hyafil, F., Laissy, J-P Mazighi, M. et al. (2006) Ferumoxtran-10-enhanced MRI of the hypercholesterolemic rabbit aorta: relationship between signal loss and macrophage infiltration. Arterioscler Thromb Vasc Biol, 26, pp. 176-181.
47. Morris, JB, Olzinski, AR Bernard, RE et al. (2008) p38 MAPK inhibition reduces aortic ultrasmall superparamagnetic iron oxide uptake in a mouse model of atherosclerosis: MRI assessment. Arterioscler Thromb Vasc Biol, 28, pp. 265-271.
48. Howarth, S., Li, ZY Trivedi, RA et al. (2007) Correlation of macrophage location and plaque stress distribution using USPIO-enhanced MRI in a patient with symptomatic severe carotid stenosis: A new insight into risk stratification. Br J Neurosurg, 21, pp. 396-398.
49. Tang, T., Howarth, SP Miller, SR et al. (2006) Assessment of inflammatory burden contralateral to the symptomatic carotid stenosis using high-resolution ultrasmall, superparamagnetic iron oxide-enhanced MRI. Stroke, 37, pp. 2266-2270.
50. Allan, R., Kass, M., Glover, C. and Haddad, H. (2007) Cellular transplantation: Future therapeutic options. Curr Opin Cardiol, 22, pp. 104-110.
51. Rogers, WJ, Meyer, CH and Kramer, CM. (2006) Technology insight: In vivo cell tracking by use of MRI. Nat Clin Pract Cardiovasc Med, 3, pp. 554-562.
52. Bulte, JWM, Ma, LD Magin, RL et al. (1993) Selective MR imaging of labeled human peripheral blood mononuclear cells by liposome mediated incorporation of dextran-magnetite particles. Magn Reson Med, 29, pp. 32-37.
53. Frank, JA, Miller, BR Arbab, AS et al. (2003) Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology, 228, pp. 480-487.
54. Arbab, AS, Yocum, GT Wilson, LB et al. (2004) Comparison of transfection agents in forming complexes with ferumoxides, cell labeling efficiency, and cellular viability. Mol Imaging, 3, pp. 24-32.
55. Arbab, AS, Yocum, GT Kalish, H. et al. (2004) Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI. Blood, 104, pp. 1217-1223.
56. Zhang, Z., van den Bos, EJ Wielopolski, PA et al. (2005) In vitro imaging of single living human umbilical vein endothelial cells with a clinical 3.0-T MRI scanner. MAGMA, 18, pp. 175-185.
57. Zhang, Z., van den Bos, EJ Wielopolski, PA et al. (2004) High-resolution magnetic resonance imaging of iron-labeled myoblasts using a standard 1.5-T clinical scanner. MAGMA, 17, pp. 201-209.
58. Kalish, H., Arbab, AS Miller, BR et al. (2003) Combination of transfection agents and magnetic resonance contrast agents for cellular imaging: Relationship between relaxivities, electrostatic forces, and chemical composition. Magn Reson Med, 50, pp. 275-282.
59. Koch, AM, Reynolds, F. Kircher, MF et al. (2003) Uptake and metabolism of a dual fluorochrome Tat-nanoparticle in HeLa cells. Bioconjug Chem, 14, pp. 1115-1121.
60. Zhao, M., Kircher, MF, Josephson, L. and Weissleder, R. (2002) Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem, 13, pp. 840-844.
61. Lewin, M., Carlesso, N. Tung, CH et al. (2000) Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotechnol, 18, pp. 410-414.
62. Walczak, P., Kedziorek, DA Gilad, AA et al. (2005) Instant MR labeling of stem cells using magnetoelectroporation. Magn Reson Med, 54, pp. 769-774.
63. Suzuki, Y., Zhang, S. Kundu, P. et al. (2007) In vitro comparison of the biological effects of three transfection methods for magnetically labeling mouse embryonic stem cells with ferumoxides. Magn Reson Med, 57, pp. 1173-1179.
64. Wu, YL, Ye, Q. Foley, LM et al. (2006) In situ labeling of immune cells with iron oxide particles: An approach to detect organ rejection by cellular MRI. Proc Natl Acad Sci USA, 103, pp. 1852-1857.
65. Amado, LC, Saliaris, AP Schuleri, KH et al. (2005) Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci USA, 102, pp. 11474-11479.
66. van den Bos, EJ, Baks, T. Moelker, AD et al. (2006) Magnetic resonance imaging of haemorrhage within reperfused myocardial infarcts: Possible interference with iron oxide-labelled cell tracking?. Eur Heart J, 27, pp. 1620-1626.
67. Stuber, M., Gilson, WD Schar, M. et al. (2007) Positive contrast visualization of iron oxide-labeled stem cells using inversion-recovery with ON-resonant water suppression (IRON). Magn Reson Med, 58, pp. 1072-1077.
68. Himes, N., Min, JY Lee, R. et al. (2004) In vivo MRI of embryonic stem cells in a mouse model of myocardial infarction. Magn Reson Med, 52, pp. 1214-1219.
69. Ruhparwar, A., Ghodsizad, A. Niehaus, M. et al. (2006) Clinically applicable 7-Tesla magnetic resonance visualization of transplanted human adult stem cells labeled with CliniMACS nanoparticles. Thorac Cardiovasc Surg, 54, pp. 447-451.
70. Baklanov, DV, Demuinck, ED Thompson, CA et al. (2004) Novel double contrast MRI technique for intramyocardial detection of percutaneously transplanted autologous cells. Magn Reson Med, 52, pp. 1438-1442.
71. Kustermann, E., Roell, W. Breitbach, M. et al. (2005) Stem cell implantation in ischemic mouse heart: A high-resolution magnetic resonance imaging investigation. NMR Biomed, 18, pp. 362-370.
72. Leor, J., Rozen, L. Zuloff-Shani, A. et al. (2006) Ex vivo activated human macrophages improve healing, remodeling, and function of the infarcted heart. Circulation, 114, p. I94.