Knowledge of carbohydrate consumption does not alter natural killer cell activity following an acute bout of high-intensity aerobic exercise

Applied Physiology, Nutrition and Metabolism

Volumn 33, Issue 5, 2008, Pages 1007-1012

  McFarlin, Brian K ^a   Hutchison, Alexander T ^b   Kueht, Michael L ^a  

^a UNIVERSITY OF HOUSTON   (United States)

^b ST MARY'S UNIVERSITY   (United States)

Author keywords

Endurance athletes; Innate immunity; Open window; Whole blood NKCA

Indexed keywords

ADULT; ARTICLE; CARBOHYDRATE DIET; CELLULAR IMMUNITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; EXERCISE; FEMALE; HEART RATE; HUMAN; IMMUNOLOGY; LEUKOCYTE COUNT; MALE; MIDDLE AGED; NATURAL KILLER CELL; OXYGEN CONSUMPTION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADULT; DIETARY CARBOHYDRATES; EXERCISE; FEMALE; HEART RATE; HUMANS; IMMUNITY, CELLULAR; KILLER CELLS, NATURAL; LEUKOCYTE COUNT; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; YOUNG ADULT;

EID: 53649103529     PISSN: 17155312     EISSN: None     Source Type: Journal    
DOI: 10.1139/H08-076     Document Type: Article

References (20)

1. Baron, G.C., Klimas, N.G., Fischl, M.A., and Fletcher, M.A. 1985. Decreased natural cell-mediated cytotoxicity per effector cell in acquired immunodeficiency syndrome. Diagn. Immunol. 3: 197-204. PMID:3866646.
2. Braun, W.A., Flynn, M.G., Jacks, D.E., McLoughlin, T., Sowash, J., Lambert, C.P., and Mylona, E. 1999. Indomethacin does not influence natural cell-mediated cytotoxic response to endurance exercise. J. Appl. Physiol. 87: 2237-2243. PMID:10601173.
3. Bruunsgaard,H.,Pedersen,A.N.,Schroll,M.,Skinhoj,P.,andPedersen, B.K. 2001. Decreased natural killer cell activity is associated with atherosclerosis in elderly humans. Exp. Gerontol. 37: 127-136. doi:10.1016/S0531-5565(01) 00162-0.PMID:11738153.
4. Fahlman, M., Boardley, D., Flynn, M.G., Braun, W.A., Lambert, C.P., and Bouillon, L.E. 2000. Effects of endurance training on selected parameters of immune function in elderly women. Gerontology, 46: 97-104. doi:10.1159/000022142. PMID:10671807.
5. Fletcher, M.A., Baron, G.C., Ashman, M.R., Fischl, M.A., and Klimas, N.G. 1987. Use of whole blood methods in assessment of immune parameters in immunodeficiency states. Diagn. Clin. Immunol. 5: 69-81. PMID:3113759.
6. Flynn, M.G., Fahlman, M., Braun, W.A., Lambert, C.P., Bouillon, L.E., Brolinson, P.G., and Armstrong, C.W. 1999. Effects of resistance training on selected indexes of immune function in elderly women. J. Appl. Physiol. 86: 1905-1913. PMID:10368355.
7. McFarlin, B.K., and Mitchell, J.B. 2003. Exercise in hot and cold environments: differential effects on leukocyte number and NK cell activity. Aviat. Space Environ. Med. 74: 1231-1236. PMID:14692464.
8. McFarlin, B.K., Mitchell, J.B., McFarlin, M.A., and Steinhoff, G.M. 2003. Repeated endurance exercise affects leukocyte number but not NK cell activity. Med. Sci. Sports Exerc. 35: 1130-1138. doi:10.1249/01.MSS.0000074463. 36752.87. PMID:12840633.
9. McFarlin, B.K., Flynn, M.G., Stewart, L.K., and Timmerman, K.L. 2004. Carbohydrate intake during endurance exercise increases natural killer cell responsiveness to IL-2. J. Appl. Physiol. 96: 271-275. doi:10.1152/japplphysiol.00585.2003. PMID:12972438.
10. McFarlin, B.K., Flynn, M.G., Phillips, M.D., Stewart, L.K., and Timmerman, K.L. 2005. Chronic resistance exercise training improves natural killer cell activity in older women. J. Gerontol. A Biol. Sci. Med. Sci. 60: 1315-1318. PMID:16282566.
11. McFarlin, B.K., Flynn, M.G., Mahon, A.K., Stewart, L.K., Timmerman, K.L., Lyle, R.M., and Campbell, W.W. 2006. Energy restriction with different protein quantities and source: implications for innate immunity. Obesity, 14: 1211-1218. doi:10.1038/oby.2006.138. PMID:16899802.
12. McFarlin, B.K., Flynn, M.G., and Hampton, T. 2007. Carbohydrate consumption during cycling increases in vitro NK cell responses to IL-2 and IFN-gamma. Brain Behav. Immun. 21: 202-208. doi:10.1016/j.bbi.2006.06. 006. PMID:16889932.
13. Mitchell, J.B., Dugas, J.P., McFarlin, B.K., and Nelson, M.J. 2002. Effect of exercise, heat stress, and hydration on immune cell number and function. Med. Sci. Sports Exerc. 34: 1941-1950. doi:10.1097/00005768- 200205001-01641. PMID:12471300.
14. Nehlsen-Cannarella, S.L., Nieman, D.C., Balk-Lamberton, A.J., Markoff, P.A., Chritton, D.B., Gusewitch, G., and Lee, J.W. 1991. The effects of moderate exercise training on immune response. Med. Sci. Sports Exerc. 23: 64-70. PMID:1997814.
15. Nieman, D.C. and Henson, D.A. 1994. Role of endurance exercise in immune senescence. Med. Sci. Sports Exerc. 26: 172-181. doi:10.1249/00005768- 199402000-00007. PMID:8164534.
16. Nieman, D.C., Nehlsen-Cannarella, S.L., Henson, D.A., Koch, A.J., Butterworth, D.E., Fagoaga, O.R., and Utter, A. 1998a. Immune response to exercise training and/or energy restriction in obese women. Med. Sci. Sports Exerc. 30: 679-686. doi:10.1097/00005768-199805000-00006. PMID:9588608.
17. Nieman, D.C., Nehlsen-Cannarella, S.L., Fagoaga, O.R., Henson, D.A., Utter, A., Davis, J.M., et al. 1998b. Influence of mode and carbohydrate on the cytokine response to heavy exertion. Med. Sci. Sports Exerc. 30: 671-678. doi:10.1097/00005768-199805000-00005. PMID:9588607.
18. Pedersen, B.K., and Ullum, H. 1994. NK cell response to physical activity: possible mechanisms of action. Med. Sci. Sports Exerc. 26: 140-146. doi:10.1249/00005768-199402000-00003. PMID:8164530.
19. Timmons, B.W., Tarnopolsky, M.A., and Bar-Or, O. 2006. Sexbased effects on the distribution of NK cell subsets in response to exercise and carbohydrate intake in adolescents. J. Appl. Physiol. 100: 1513-1519. doi:10.1152/japplphysiol.01125.2005. PMID:16410379.
20. Woods, J.A., Ceddia, M.A., Wolters, B.W., Evans, J.K., Lu, Q., and McAuley, E. 1999. Effects of 6 months of moderate aerobic exercise training on immune function in the elderly. Mech. Ageing Dev. 109: 1-19. doi:10.1016/S0047-6374(99)00014-7. PMID:10405985.