Repeated endurance exercise affects leukocyte number but not NK cell activity

Medicine and Science in Sports and Exercise

Volumn 35, Issue 7, 2003, Pages 1130-1138

  McFarlin, Brian K ^a,b   Mitchell, Joel B ^a   McFarlin, Meredith A ^a   Steinhoff, Gina M ^a  

^a TEXAS CHRISTIAN UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Aerobic exercise; Diet; Immunity; Multiple bout; Whole blood cytoxicity assay

Indexed keywords

ADULT; ARTICLE; BICYCLE ERGOMETRY; CELL ACTIVITY; CELL SUBPOPULATION; CIRCADIAN RHYTHM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENDURANCE; EXERCISE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LEUKOCYTE COUNT; MALE; NATURAL KILLER CELL; NEUTROPHIL; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL;

EID: 0038693139     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1249/01.MSS.0000074463.36752.87     Document Type: Article

References (32)

1. AMERICAN COLLEGE OF SPORTS MEDICINE. Guidelines for Exercise Testing and Prescription, 4th Ed. Philadelphia: Lea & Febiger, 1991, pp. 1-373.
2. BARON, G. C., N. C. KLIMAS, M. A. FISCHL, and M. A. FLETCHER. Decreased natural cell-mediated cytoxicity per effector cell in acquired immunodeficiency syndrome. Diagn. Immunol. 3:197-204, 1985.
3. BRAUN, W. A., M. G. FLYNN, D. E. JACKS, et al. Indomethacin does not influence natural cell-mediated cytotoxic response to endurance exercise. J. Appl. Physiol. 87:2237-2243, 1999.
4. DELAHANTY, D. L., T. WANG, C. MARAVICH, M. FORLENZA, and A. BAUM. Time-of-day effects on response of natural killer cells to acute stress in men and women. Health Psychol. 19:39-45, 2000.
5. DILL, D. B., and D. L. COSTILL. Calculation of percentage changes in volumes of blood plasma, and red cells in dehydration. J. Appl. Physiol. 37:247-1248, 1974.
6. FLETCHER, M. A., G. C. BARON, M. R. ASHMAN, M. A. FISCHL, and N. G. KLIMAS. Use of whole blood methods in assessment of immune parameters in immunodeficiency states. Diagn. Clin. Immunol. 5:69-81, 1987.
7. FLYNN, M. G., M. A. FAHLMAN, W. A. BRAUN, et al. Effects of resistance training on selected indexes of immune function in elderly women. J. Appl. Physiol. 86:1905-1913, 1999.
8. GATTI, G., D. DEL PONTE, R. CAVALLO, et al. Circadian changes in human natural killer-cell activity. Prog. Clin. Biol. Res. 227A:399-409, 1987.
9. HENSON, D. A., D. C. NIEMAN, S. L. NEHLSEN-CANNARELLA, et al. Influence of carbohydrate on cytokine and phagocytic responses to 2 h of rowing. Med. Sci. Sports Exerc. 32:1384-1389, 2000.
10. JACKSON, A. S., and M. L. POLLOCK. Generalized equations for predicting body density of men. Br. J. Nutr. 40:497-504, 1978.
11. KAPPEL, M., N. TVEDE, H. GALBO, et al. Evidence that the effect of physical exercise on NK cell activity in mediated by epinephrine. J. Appl. Physiol. 70:2530-2534, 1991.
12. MACKINNON, L. T. Special feature for the Olympics: effects of exercise on the immune system: overtraining effects on immunity and performance in athletes. Immunol. Cell Biol. 78:502-509, 2000.
13. MCCARTHY, D. A., I. MACDONALD, M. GRANT, et al. Studies on the immediate and delayed leukocytosis elicited by brief (30-min) strenuous exercise. Eur. J. Appl. Physiol. 64:513-517, 1992.
14. MITCHELL, J. B., F. X. PIZZA, A. PAQUET, B. J. DAVIS, M. B. FORREST, and W. A. BRAUN. Influence of carbohydrate status on immune responses before and after endurance exercise. J. Appl. Physiol. 84:1917-1925, 1998.
15. NIELSEN, H. B., N. H. SECHER, N. J. CHRISTENSEN, and B. K. PEDERSEN. Lymphocytes and NK cell activity during repeated bouts of maximal exercise. Am. J. Physiol. 271(1 Pt. 2):R222-R227, 1996.
16. NIEMAN, D. C. Immune response to heavy exertion. J. Appl. Physiol. 82:1385-1394, 1997.
17. NIEMAN, D. C. Exercise, infection, and immunity. Int. J. Sports Med. 15(Suppl.):S131-S141, 1994.
18. NIEMAN, D. C., D. A. HENSON, C. S. SAMPSON, et al. The acute immune response to exhaustive exercise. Int. J. Sports Med. 16:322-328, 1995.
19. NIEMAN, D. C., A. R. MILLER, D. A. HENSON, et al. Effects of high- vs moderate-intensity exercise and natural killer cell activity. Med. Sci. Sports Exerc. 25:1126-1134, 1993.
20. PEDERSEN, B. K. Influence of physical activity on the cellular immune system: mechanisms of action. Int. J. Sports Med. 12: S23-S29, 1991.
21. PEDERSEN, B. K., and H. ULLUM. NK cell response to physical activity: possible mechanisms of action. Med. Sci. Sports Exerc. 26:140-146, 1994.
22. PEDERSEN, B. K., T. ROHDE, and M. ZACHO. Immunity in athletes. J. Sports Med. Phys. Fitness 36:236-245, 1996.
23. PEDERSEN, B. K., J. W. HELGE, E. A. RICHTER, T. ROHDE, and B. KIENS. Training and natural immunity: effects of diets rich in fat or carbohydrate. Eur. J. Appl. Physiol. 82:98-102, 2000.
24. RONSEN, O., E. HAUG, B. K. PEDERSEN, and R. BAHR. Increased neuroendocrine response to a repeated bout of endurance exercise. Med. Sci. Sports Exerc. 33:568-575, 2001.
25. RONSEN, O., B. K. PEDERSEN, T. R. ORITSLAND, R. BAHR, and J. KJELDSEN-KRAGH. Leukocyte counts and lymphocyte responsiveness associated with repeated bouts of strenuous endurance exercise. J. Appl. Physiol. 91:425-434, 2001.
26. SEVERS, Y., I. BRENNER, P. N. SHEK, and R. J. SHEPHARD. Effects of heat and intermittent exercise on leukocyte and sub-population cell counts. Eur. J. Appl. Physiol. Occup. Physiol. 74:234-245, 1996.
27. SHEPHARD, R. J., and P. N. SHEK. Effects of exercise and training on natural killer cell counts and cytotoxic activity: a meta-analysis. Sports Med. 28:177-196, 1999.
28. SHINKAI, S. S., P. N. SHORE, P. N. SHEK, and R. J. SHEPHARD. Acute exercise and immune function: relationship between lymphocyte activity and changes in subset counts. Int. J. Sports Med. 13:452-461, 1992.
29. SMITH, L. L., J. A. BOND, D. HOLBERT, et al. Differential white cell counts after two bouts of downhill running. Int. J. Sports Med. 19:432-437, 1998.
30. WANG, T., D. L. DELAHANTY, A. L. DOUGALL, and A. BAUM. Responses of natural killer cell activity to acute laboratory stressors in healthy men at different times of day. Health Psychol. 17:428-435, 1998.
31. WOODS, J. A., J. M. DAVIS, J. A. SMITH, and D. C. NIEMAN. Exercise and cellular innate immune function. Med. Sci. Sports Exerc. 31:57-66, 1999.
32. YAQOOB, P., E. A. NEWSHOLME, and P. C. CALDER. Inhibition of natural killer cell activity by dietary lipids. Immunol. Lett. 41:241-247, 1994.