Synthesis of five nevirapine metabolites

Journal of Heterocyclic Chemistry

Volumn 37, Issue 2, 2000, Pages 229-239

  Grozinger, Karl G ^a   Byrne, Denis P ^a   Nummy, Laurence J ^a   Ridges, Michael D ^a   Salvagno, Annette ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; NEVIRAPINE;

ARTICLE; BIOTRANSFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; SYNTHESIS;

EID: 0034120630     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570370203     Document Type: Article

References (14)

1. R. L. Murphy and J. Montaner, Exp. Opin. Invest. Drugs, 5, 1183 (1996).
2. P. S. Riska, D. P. Joseph, R. P. Dinallo, S. E. Hattox and J. J. Keirns, Department of Drug Metabolism and Pharmacokinetics and Department of Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc.; Ridgefield, CT 06877, Posters at the 7th North American ISSX Meeting, San Diego, October 1996.
3. [3a] P. S. Riska, M. J. Lamson, J. P. Sabo, S. E. Hattox and J. J. Keirns, Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, Posters at the 7th North American ISSX Meeting, San Diego, October 1996;
4. [3b] P. Riska, M. Lamson, T. MacGregor, J. Sabo, S. Hattox, J. Pav and J. Keirns; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, Drug Metabolism and Disposition, 27, 895 (1999).
5. K. Grozinger, V. Fuchs, K. D. Hargrave, S. Mauldin, J. Vitous, S. Campbell and J. Adams, J. Heterocyclic Chem., 32, 259 (1995).
6. J. R. Proudfoot, K. D. Hargrave, S. R. Kapadia, U. R. Patel, K. G. Grozinger, D. W. McNeil, E. Cullen, M. Cardozo, L. Tong, T. A. Kelly, J. Rose, E. David, S. C. Mauldin, V. U. Fuchs, J. Vitous, M. Hoermann, J. M. Klunder, P. Raghavan, J. W. Skiles, P. Mui, D. D. Richman, J. L. Sullivan, C. Shih, P. M. Grob and J. Adams, J. Med. Chem., 38, 4830 (1995).
7. J. M. Klunder, J. Heterocyclic Chem., 32, 1687 (1995).
8. U. R. Patel and J. R. Proudfoot, J. Org. Chem., 57, 4023 (1992).
9. Method for the preparation of 3-Amino-2-chloro-4-alkyl pyridines, U.S. Patent 5,654,429, August 1997.
10. Föster, et al. Boehringer Ingelheim KG, unpublished results.
11. W. P. Griffith and S. V. Ley, Aldrichimica Acta., 23, 13 (1990).
12. K. D. Hargrave, J. R. Proudfoot, K. G. Grozinger, E. Cullen, S. R. Kapadia, U. R. Patel, V. U. Fuchs, S. C. Mauldin, J. Vitous, M. L. Behnke, J. M. Klunder, K. Pal, J. W. Skiles, D. W. McNeil, J. M. Rose, G. C. Chow, M. T. Skoog, J. C. Wu, G. Schmidt, W. W. Engel, W. G. Eberlein, T. D. Saboe, S. J. Campbell, A. S. Rosenthal and J. Adams, J. Med. Chem., 34, 2231 (1991).
13. C. L. Cywin, J. M. Klunder, M. A. Hoermann, P. M. Grob, C.-K. Shih, E. David, J. R. Brickwood, D. Pauletti, R. Schwartz, K. J. Barringer, 214th National Meeting of the American Chemical Society, Las Vegas, NV, September 7-11, 1997, poster, Abstract MEDI 176.
14. J. M. Klunder, M. Hoermann, C. L. Cywin, E. David, J. R. Brickwood, R. Schwartz, K. J. Barringer, D. Pauletti, C.-K. Shih, D. A. Erickson, C. L. Sorge, D. P. Joseph, S. E. Hattox, J. Adams, and P. M. Grob, J. Med. Chem., 41, 2960 (1998).