메뉴 건너뛰기




Volumn 27, Issue 3, 2008, Pages 309-320

Selectivity-based QSAR approach for screening and evaluation of TRH analogs for TRH-R1 and TRH-R2 receptors subtypes

Author keywords

GFA; Selectivity based QSAR; TRH; TRH R1; TRH R2

Indexed keywords

GFA; SELECTIVITY-BASED QSAR; TRH; TRH-R1; TRH-R2;

EID: 53549113051     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmgm.2008.05.005     Document Type: Article
Times cited : (2)

References (45)
  • 1
    • 0014666196 scopus 로고
    • The identity of chemical and hormonal properties of the thyrotropin-releasing hormone and pyroglutamyl-histidyl-prolinamide
    • Böler R., Enzman F., Folkers K., Bowers C., and Schally A.V. The identity of chemical and hormonal properties of the thyrotropin-releasing hormone and pyroglutamyl-histidyl-prolinamide. Biochem. Biophys. Res. Commun. 37 (1969) 705-710
    • (1969) Biochem. Biophys. Res. Commun. , vol.37 , pp. 705-710
    • Böler, R.1    Enzman, F.2    Folkers, K.3    Bowers, C.4    Schally, A.V.5
  • 2
    • 0014672936 scopus 로고
    • Derives Polypeptidiques de Syntheses Doues d'activite Hypophysiotropic TRF
    • Burgus R., Dunn T., Desiderio D., and Guillemin R. Derives Polypeptidiques de Syntheses Doues d'activite Hypophysiotropic TRF. C. R. Acad. Sci. 269 (1969) 1870-1873
    • (1969) C. R. Acad. Sci. , vol.269 , pp. 1870-1873
    • Burgus, R.1    Dunn, T.2    Desiderio, D.3    Guillemin, R.4
  • 4
    • 0016314577 scopus 로고
    • Enhancement of cerebral noradrenaline turnover by thyrotropin-releasing hormone
    • Keller H.H., Bartholini G., and Plestscher A. Enhancement of cerebral noradrenaline turnover by thyrotropin-releasing hormone. Nature 248 (1974) 528-529
    • (1974) Nature , vol.248 , pp. 528-529
    • Keller, H.H.1    Bartholini, G.2    Plestscher, A.3
  • 5
    • 0015910459 scopus 로고
    • In vivo stimulation of prolactin release in the rat by synthetic TRH
    • Muller G.P., Chen H.J., and Meites J. In vivo stimulation of prolactin release in the rat by synthetic TRH. Proc. Soc. Exp. Biol. Med. 144 (1973) 613-615
    • (1973) Proc. Soc. Exp. Biol. Med. , vol.144 , pp. 613-615
    • Muller, G.P.1    Chen, H.J.2    Meites, J.3
  • 6
    • 0016332624 scopus 로고
    • TRH: a possible mediator of thermoregulation
    • Metcalf G. TRH: a possible mediator of thermoregulation. Nature 252 (1974) 310-311
    • (1974) Nature , vol.252 , pp. 310-311
    • Metcalf, G.1
  • 7
    • 0023894497 scopus 로고
    • Structure activity relationships of TRH analogs in experimental spinal injury
    • Faden A.I., Sacksen I., and Noble L.J. Structure activity relationships of TRH analogs in experimental spinal injury. Brain Res. 448 (1988) 287-293
    • (1988) Brain Res. , vol.448 , pp. 287-293
    • Faden, A.I.1    Sacksen, I.2    Noble, L.J.3
  • 8
    • 0023605818 scopus 로고
    • Treatment of experimental spinal trauma with thyrotropin-releasing hormone: central serotonergic and vascular mechanisms of action
    • Salzman S.K., Hirofugi E., Knight P.B., Llados-Eckman C., Beckman A.L., and Winokur A. Treatment of experimental spinal trauma with thyrotropin-releasing hormone: central serotonergic and vascular mechanisms of action. Cent. Nerv. Syst. Trauma 4 (1987) 181-196
    • (1987) Cent. Nerv. Syst. Trauma , vol.4 , pp. 181-196
    • Salzman, S.K.1    Hirofugi, E.2    Knight, P.B.3    Llados-Eckman, C.4    Beckman, A.L.5    Winokur, A.6
  • 9
    • 0036389891 scopus 로고    scopus 로고
    • Central nervous system effects of thyrotropin-releasing hormone and its analogues: opportunities and perspectives for drug discovery and development
    • Prokai L. Central nervous system effects of thyrotropin-releasing hormone and its analogues: opportunities and perspectives for drug discovery and development. Prog. Drug Res. 59 (2002) 134-169
    • (2002) Prog. Drug Res. , vol.59 , pp. 134-169
    • Prokai, L.1
  • 10
    • 0025607860 scopus 로고
    • Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor
    • Straub R.E., French G.C., Joho R.H., and Gershengorn M.C. Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 9514-9518
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 9514-9518
    • Straub, R.E.1    French, G.C.2    Joho, R.H.3    Gershengorn, M.C.4
  • 11
    • 0027101754 scopus 로고
    • Two isoforms of the thyrotropin-releasing hormone receptor generated by alternative splicing have indistinguishable functional properties
    • De la Pena P., Delgado L.M., Del Camino D., and Barros F. Two isoforms of the thyrotropin-releasing hormone receptor generated by alternative splicing have indistinguishable functional properties. J. Biol. Chem. 267 (1992) 25703-25708
    • (1992) J. Biol. Chem. , vol.267 , pp. 25703-25708
    • De la Pena, P.1    Delgado, L.M.2    Del Camino, D.3    Barros, F.4
  • 13
    • 0031730115 scopus 로고    scopus 로고
    • Cloning and characterization of the chicken thyrotropin-releasing hormone receptor
    • Sun Y.M., Millar R.P., Ho H., Gershengorn M.C., and Illing N. Cloning and characterization of the chicken thyrotropin-releasing hormone receptor. Endocrinology 139 (1998) 3390-3398
    • (1998) Endocrinology , vol.139 , pp. 3390-3398
    • Sun, Y.M.1    Millar, R.P.2    Ho, H.3    Gershengorn, M.C.4    Illing, N.5
  • 15
    • 0035092112 scopus 로고    scopus 로고
    • Regulator of G protein signaling 4 suppresses basal and thyrotropin-releasing hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2)
    • Harder S., Lu X., Wang W., Buck F., Gershengorn M.C., and Bruhn T.O. Regulator of G protein signaling 4 suppresses basal and thyrotropin-releasing hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2). Endocrinology 142 (2001) 1188-1194
    • (2001) Endocrinology , vol.142 , pp. 1188-1194
    • Harder, S.1    Lu, X.2    Wang, W.3    Buck, F.4    Gershengorn, M.C.5    Bruhn, T.O.6
  • 17
    • 0034463026 scopus 로고    scopus 로고
    • TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1
    • O'Dowd B.F., Lee D.K., Huang W., Nguyen T., Cheng R., Liu Y., Wang B., Gershengorn M.C., and George S.R. TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1. Mol. Endocrinol. 14 (2000) 183-193
    • (2000) Mol. Endocrinol. , vol.14 , pp. 183-193
    • O'Dowd, B.F.1    Lee, D.K.2    Huang, W.3    Nguyen, T.4    Cheng, R.5    Liu, Y.6    Wang, B.7    Gershengorn, M.C.8    George, S.R.9
  • 18
    • 0038025925 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone receptors-similarities and differences
    • Sun Y., Lu X., and Gershengorn M.C. Thyrotropin-releasing hormone receptors-similarities and differences. J. Mol. Endocrinol. 30 (2003) 87-97
    • (2003) J. Mol. Endocrinol. , vol.30 , pp. 87-97
    • Sun, Y.1    Lu, X.2    Gershengorn, M.C.3
  • 19
    • 33750948053 scopus 로고    scopus 로고
    • Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1
    • Kaur N., Monga V., Lu X., Gershengorn M.C., and Jain R. Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1. Bioorg. Med. Chem. 15 (2007) 433-443
    • (2007) Bioorg. Med. Chem. , vol.15 , pp. 433-443
    • Kaur, N.1    Monga, V.2    Lu, X.3    Gershengorn, M.C.4    Jain, R.5
  • 20
    • 33746068234 scopus 로고    scopus 로고
    • Synthesis, receptor binding and activation studies of N(1)-alkyl-l-histidine containing thyrotropin-releasing hormone (TRH) analogues
    • Kaur N., Monga V., Josan J.S., Lu X., Gershengorn M.C., and Jain R. Synthesis, receptor binding and activation studies of N(1)-alkyl-l-histidine containing thyrotropin-releasing hormone (TRH) analogues. Bioorg. Med. Chem. 14 (2006) 5980-5987
    • (2006) Bioorg. Med. Chem. , vol.14 , pp. 5980-5987
    • Kaur, N.1    Monga, V.2    Josan, J.S.3    Lu, X.4    Gershengorn, M.C.5    Jain, R.6
  • 22
    • 24944543834 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone (TRH) analogues that exhibit selectivity to TRH receptor subtype 2
    • Kaur N., Lu X., Gershengorn M.C., and Jain R. Thyrotropin-releasing hormone (TRH) analogues that exhibit selectivity to TRH receptor subtype 2. J. Med. Chem. 48 (2005) 6162-6165
    • (2005) J. Med. Chem. , vol.48 , pp. 6162-6165
    • Kaur, N.1    Lu, X.2    Gershengorn, M.C.3    Jain, R.4
  • 23
    • 0036131919 scopus 로고    scopus 로고
    • Synthesis and biology of new thyrotropin-releasing hormone (TRH) analogues
    • Jain R., Singh J., Perlman J.H., and Gershengorn M.C. Synthesis and biology of new thyrotropin-releasing hormone (TRH) analogues. Bioorg. Med. Chem. 10 (2002) 189-194
    • (2002) Bioorg. Med. Chem. , vol.10 , pp. 189-194
    • Jain, R.1    Singh, J.2    Perlman, J.H.3    Gershengorn, M.C.4
  • 24
    • 0031444103 scopus 로고    scopus 로고
    • Role of the extracellular loops of the thyrotropin-releasing hormone receptor: evidence for an initial interaction with thyrotropin-releasing hormone
    • Perlman J.H., Colson A.O., Jain R., Czyzewski B., Cohen L.A., Osman R., and Gershengorn M.C. Role of the extracellular loops of the thyrotropin-releasing hormone receptor: evidence for an initial interaction with thyrotropin-releasing hormone. Biochemistry 36 (1997) 15670-15676
    • (1997) Biochemistry , vol.36 , pp. 15670-15676
    • Perlman, J.H.1    Colson, A.O.2    Jain, R.3    Czyzewski, B.4    Cohen, L.A.5    Osman, R.6    Gershengorn, M.C.7
  • 25
    • 53549084370 scopus 로고    scopus 로고
    • SYBYL, 7.1, Tripos Associates Inc., 1699, S. Hanley Road, St. Louis, MO631444, USA.
    • SYBYL, 7.1, Tripos Associates Inc., 1699, S. Hanley Road, St. Louis, MO631444, USA.
  • 26
    • 0842341771 scopus 로고
    • AM1: a new general purpose quantum mechanical molecular model
    • Dewar J.S., Zoebisch E.G., and Healy E.F. AM1: a new general purpose quantum mechanical molecular model. J. Am. Chem. Soc. 107 (1985) 3902-3909
    • (1985) J. Am. Chem. Soc. , vol.107 , pp. 3902-3909
    • Dewar, J.S.1    Zoebisch, E.G.2    Healy, E.F.3
  • 27
    • 20444404916 scopus 로고    scopus 로고
    • Assessing the reliability of a QSAR model's predictions
    • Linnan H., and Jurs P.C. Assessing the reliability of a QSAR model's predictions. J. Mol. Graph. Model. 23 (2005) 503-523
    • (2005) J. Mol. Graph. Model. , vol.23 , pp. 503-523
    • Linnan, H.1    Jurs, P.C.2
  • 28
    • 34250855745 scopus 로고    scopus 로고
    • Evaluation of Pseudomonas aeruginosa deacetylase LpxC inhibitory activity of dual PDE4-TNF-alpha inhibitors: a multiscreening approach
    • Kadam R.U., Garg D., Chavan A., and Roy N. Evaluation of Pseudomonas aeruginosa deacetylase LpxC inhibitory activity of dual PDE4-TNF-alpha inhibitors: a multiscreening approach. J. Chem. Inf. Model. 47 (2007) 1188-1195
    • (2007) J. Chem. Inf. Model. , vol.47 , pp. 1188-1195
    • Kadam, R.U.1    Garg, D.2    Chavan, A.3    Roy, N.4
  • 29
    • 33747364217 scopus 로고    scopus 로고
    • Cluster analysis and two-dimensional quantitative structure-activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors
    • Kadam R.U., and Roy N. Cluster analysis and two-dimensional quantitative structure-activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors. Bioorg. Med. Chem. Lett. 19 (2006) 5136-5143
    • (2006) Bioorg. Med. Chem. Lett. , vol.19 , pp. 5136-5143
    • Kadam, R.U.1    Roy, N.2
  • 30
    • 11644266970 scopus 로고
    • Electronic population analysis on LCAO-MO molecular wave function I
    • Mulliken R.S. Electronic population analysis on LCAO-MO molecular wave function I. J. Chem. Phys. 23 (1955) 1833-1846
    • (1955) J. Chem. Phys. , vol.23 , pp. 1833-1846
    • Mulliken, R.S.1
  • 31
    • 53549096280 scopus 로고    scopus 로고
    • Dragon, 5.3, Milano Chemometrics and QSAR Research Groups Inc., 2002.
    • Dragon, 5.3, Milano Chemometrics and QSAR Research Groups Inc., 2002.
  • 32
    • 53549108905 scopus 로고    scopus 로고
    • R. Buigni, Quantitative structure activity relationships (QSAR) models of mutagens and carcinogens, pp. 1-40.
    • R. Buigni, Quantitative structure activity relationships (QSAR) models of mutagens and carcinogens, pp. 1-40.
  • 33
    • 33244494239 scopus 로고    scopus 로고
    • Quantitative structure-activity relationship modeling of juvenile hormone mimetic compounds for Culex pipiens larvae, with a discussion of descriptor-thinning methods
    • Basak S.C., Natarajan R., Mills D., Hawkins D.M., and Kraker J.J. Quantitative structure-activity relationship modeling of juvenile hormone mimetic compounds for Culex pipiens larvae, with a discussion of descriptor-thinning methods. J. Chem. Inf. Model. 46 (2006) 65-77
    • (2006) J. Chem. Inf. Model. , vol.46 , pp. 65-77
    • Basak, S.C.1    Natarajan, R.2    Mills, D.3    Hawkins, D.M.4    Kraker, J.J.5
  • 34
    • 0028467707 scopus 로고
    • Application of genetic function approximation to quantitative structure-activity relationships and quantitative structure-property relationships
    • Rogers D., and Hopfinger A.J. Application of genetic function approximation to quantitative structure-activity relationships and quantitative structure-property relationships. J. Chem. Inf. Comput. Sci. 34 (1994) 854-866
    • (1994) J. Chem. Inf. Comput. Sci. , vol.34 , pp. 854-866
    • Rogers, D.1    Hopfinger, A.J.2
  • 35
    • 53549120660 scopus 로고    scopus 로고
    • 2, Version 4.9, Accelrys Inc., 6985 Scranton Road, San Diego, CA, USA.
    • 2, Version 4.9, Accelrys Inc., 6985 Scranton Road, San Diego, CA, USA.
  • 37
    • 53549096546 scopus 로고    scopus 로고
    • J. Gasteiger, Chemoinformatics, A Textbook, Wiley-VCH, GmbH and Co., pp. 415-428.
    • J. Gasteiger, Chemoinformatics, A Textbook, Wiley-VCH, GmbH and Co., pp. 415-428.
  • 38
    • 53549122269 scopus 로고    scopus 로고
    • R. Todeschini, V. Consoni, Handbook of Molecular Descriptors. In Method and Principals of Medicinal Chemistry, Wiley-VCH, pp. 492-513.
    • R. Todeschini, V. Consoni, Handbook of Molecular Descriptors. In Method and Principals of Medicinal Chemistry, Wiley-VCH, pp. 492-513.
  • 39
    • 48849113683 scopus 로고    scopus 로고
    • 20-(S)-Camptothecin analogues as DNA topoisomerase I inhibitors: a QSAR study
    • Hansch C., and Verma R.P. 20-(S)-Camptothecin analogues as DNA topoisomerase I inhibitors: a QSAR study. Chem. Med. Chem. 2 (2007) 1807-1813
    • (2007) Chem. Med. Chem. , vol.2 , pp. 1807-1813
    • Hansch, C.1    Verma, R.P.2
  • 40
    • 28544441042 scopus 로고    scopus 로고
    • Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study
    • Selassie C.D., Kapur S., Verma R.P., and Rosario M. Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study. J. Med. Chem. 48 (2005) 7234-7242
    • (2005) J. Med. Chem. , vol.48 , pp. 7234-7242
    • Selassie, C.D.1    Kapur, S.2    Verma, R.P.3    Rosario, M.4
  • 41
    • 0038724207 scopus 로고    scopus 로고
    • The importance of being earnest: validation is the absolute essential for successful application and interpretation of QSPR models
    • Tropsha A., Gramatica P., and Gombar V.K. The importance of being earnest: validation is the absolute essential for successful application and interpretation of QSPR models. QSAR Comb. Sci. 22 (2003) 69-77
    • (2003) QSAR Comb. Sci. , vol.22 , pp. 69-77
    • Tropsha, A.1    Gramatica, P.2    Gombar, V.K.3
  • 43
    • 28244451872 scopus 로고    scopus 로고
    • Inhibition of neutrophil elastase and thrombin activity by caffeic acid esters
    • Melzig M.F., Tran G.D., Henke K., Selassie C.D., and Verma R.P. Inhibition of neutrophil elastase and thrombin activity by caffeic acid esters. Pharmazie 60 (2005) 869-873
    • (2005) Pharmazie , vol.60 , pp. 869-873
    • Melzig, M.F.1    Tran, G.D.2    Henke, K.3    Selassie, C.D.4    Verma, R.P.5
  • 45
    • 0037838701 scopus 로고    scopus 로고
    • Improving opportunities for regulatory acceptance of QSARs: the importance of model domain, uncertainty, validity and predictability
    • Walkera J.D., Carlsenb L., and Jaworskac J. Improving opportunities for regulatory acceptance of QSARs: the importance of model domain, uncertainty, validity and predictability. QSAR Comb. Sci. 22 (2003) 346-350
    • (2003) QSAR Comb. Sci. , vol.22 , pp. 346-350
    • Walkera, J.D.1    Carlsenb, L.2    Jaworskac, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.