Synthesis, receptor binding, and activation studies of N(1)-alkyl-l-histidine containing thyrotropin-releasing hormone (TRH) analogues

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 17, 2006, Pages 5981-5988

  Kaur, Navneet ^a   Monga, Vikramdeep ^a   Josan, Jatinder S ^a   Lu, Xinping ^b   Gershengorn, Marvin C ^b   Jain, Rahul ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

1 Alkyl l histidine; Peptides; TRH; TRH receptor subtype 1; TRH receptor subtype 2

Indexed keywords

HISTIDINE DERIVATIVE; PROTIRELIN DERIVATIVE;

ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HYDROPHOBICITY; POLARIZATION; STEREOCHEMISTRY; SUBSTITUTION REACTION;

HISTIDINE; MOLECULAR STRUCTURE; PROTEIN BINDING; RECEPTORS, THYROTROPIN-RELEASING HORMONE; THYROTROPIN-RELEASING HORMONE;

EID: 33746068234     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.05.031     Document Type: Article

References (24)

1. Boler J., Enzmann F., Folkers K., Bowers C.Y., and Schally A.V. Biochem. Biophys. Res. Commun. 37 (1969) 705
2. Burgus R., Dunn J.F., Desiderio D., and Guillemin R. C.R. Acad. Sci. (Paris) 269 (1969) 1870
3. Metcalf G., and Jackson I.M.D. Ann. N.Y. Acad. Sci. 553 (1989) 1
4. Griffiths E.C. Clin. Sci. 73 (1987) 449
5. Kelly J.A. Essays Biochem. 30 (1995) 133
6. Prokai L. Prog. Drug Res. 59 (2002) 134
7. Straub R.E., French G.C., Joho R.H., and Gershengorn M.C. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 9514
8. de la Pena P., Delgado L.M., del Camino D., and Barros F. J. Biol. Chem. 267 (1992) 25703
9. Duthie S.M., Taylor P.L., Anderson L., Cook J., and Eidne K.A. Mol. Cell. Endocrinol. 95 (1993) R11
10. Sun Y.M., Millar R.P., Ho H., Gershengorn M.C., and Illing N. Endocrinology 139 (1998) 3390
11. Cao J., O'Donnell D., Vu H., Payza K., Pou C., Godbout C., Jakob A., Pelletier M., Lembo P., Ahmad S., and Walker P. J. Biol. Chem. 273 (1998) 32281
12. Harder S., Lu X., Wang W., Buck F., Gershengorn M.C., and Bruhn T.O. Endocrinology 142 (2001) 1188
13. Itadani H., Nakamura T., Itoh J., Iwaasa H., Kanatani A., Borkowski J., Ihara M., and Ohta M. Biochem. Biophys. Res. Commun. 250 (1998) 68
14. O'Dowd B.F., Lee D.K., Huang W., Nguyen T., Cheng R., Liu Y., Wang B., Gershengorn M.C., and George S.R. Mol. Endocrinol. 14 (2000) 183
15. Sun Y., Lu X., and Gershengorn M.C. J. Mol. Endocrinol. 30 (2003) 87
16. Perlman J.H., Laakkonen L.J., Guarnieri F., Osman R., and Gershengorn M.C. Biochemistry 35 (1996) 7643
17. Jain R., Singh J., Perlman J.H., and Gershengorn M.C. Bioorg. Med. Chem. 10 (2002) 189
18. Kaur N., Lu X., Gershengorn M.C., and Jain R. J. Med. Chem. 48 (2005) 6162
19. Vale W., Rivier J., and Burgus R. Endocrinology 89 (1971) 1485
20. Kaur N., Monga V., and Jain R. Tetrahedron Lett. 45 (2004) 6883
21. Jain R., and Cohen L.A. Tetrahedron 52 (1996) 5363
22. Perlman J.H., Thaw C.N., Laakkonen L., Bowers C.Y., Osman R., and Gershengorn M.C. J. Biol. Chem. 269 (1994) 1610
23. Lu X., Huang W., Worthington S., Drabik P., Osman R., and Gershengorn M.C. Mol. Pharmacol. 66 (2004) 1192
24. Engel S., Neumann S., Kaur N., Monga V., Jain R., Northup J., and Gershengorn M.C. J. Biol. Chem. 281 (2006) 13103