Identification of BRAF inhibitors through in silico screening

Journal of Medicinal Chemistry

Volumn 51, Issue 19, 2008, Pages 6121-6127

  Luo, Cheng ^a,b   Xie, Peng ^a   Marmorstein, Ronen ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; B RAF KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PURINE DERIVATIVE; RAF PROTEIN; RAS PROTEIN; SB 590885; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME SPECIFICITY; HIGH THROUGHPUT SCREENING; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

ALGORITHMS; BINDING SITES; CLONING, MOLECULAR; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; SENSITIVITY AND SPECIFICITY; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 53549110555     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800539g     Document Type: Article

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