Analysis of single, purified inclusions as a novel approach to understand methamphetamine neurotoxicity

Annals of the New York Academy of Sciences

Volumn 1139, Issue , 2008, Pages 186-190

  Lenzi, Paola ^a   Fulceri, Federica ^a   Lazzeri, Gloria ^a   Casini, Alessandro ^a   Ruggieri, Stefano ^b   Paparelli, Antonio ^a   Fornai, Francesco ^a,b  

^a UNIVERSITY OF PISA   (Italy)

^b Laboratory of Neurobiology of Movement Disorders   (Italy)

Author keywords

Inclusion purification; Inclusion structure; Magnetic beads; Neurodegeneration

Indexed keywords

METHAMPHETAMINE;

ANIMAL CELL; CELL COUNT; CELL INCLUSION; CELL MATURATION; CELL STRAIN; CONFERENCE PAPER; DEGENERATIVE DISEASE; DOPAMINERGIC NERVE CELL; IMMUNOMAGNETIC SEPARATION; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PROTEOMICS; RAT;

EID: 53549108890     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1432.014     Document Type: Conference Paper

References (29)

1. Gibb, J.W., M. Johnson & G.R. Hanson. 1990. Neurochemical basis of neurotoxicity. Neurotoxicology 11 : 317 321.
2. Seiden, L.S., R. Lew & J.E. Malberg. 2001. Neurotoxicity of methamphetamine and methylenedioxymethamphetamine. Neurotox. Res. 3 : 101 116.
3. Hanson, G.R., V. Sandoval, E. Riddle, et al. 2004. Psychostimulants and vesicle trafficking: a novel mechanism and therapeutic implication. Ann. N. Y. Acad. Sci. 1025 : 146 150.
4. Riddle, E.L., A.E. Fleckenstein & G.R. Hanson. 2006. Mechanisms of methamphetamine-induced dopaminergic neurotoxicity. A.A.P.S. J. 8 : 413 418.
5. Lazzeri, G., P. Lenzi, C.L. Busceti, et al. 2007. Mechanisms involved in the formation of dopamine-induced intracellular bodies within striatal neurons. J. Neurochem. 101 : 1414 1427.
6. Larsen, K.E., E.A. Fon, T.G. Hastings, et al. 2002. Methamphetamine- induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. J. Neurosci. 22 : 8951 8960.
7. Fornai, F., P. Lenzi, M. Ferrucci, et al. 2005a. Occurrence of neuronal inclusions combined with increased nigral expression of alpha-synuclein within dopaminergic neurons following treatment with amphetamine derivatives in mice. Brain Res. Bull. 65 : 405 413.
8. Fornai, F., P. Lenzi, M. Gesi, et al. 2004. Similarities between methamphetamine toxicity and proteasome inhibition. Ann. N. Y. Acad. Sci. 1025 : 162 170.
9. Quan, L., T. Ishikawa, T. Michiue, et al. 2005. Ubiquitin-immunoreactive structures in the midbrain of methamphetamine abusers. Leg. Med. 7 : 144 150.
10. Pollanen, M.S., D.W. Dickson & C. Bergeron. 1993. Pathology and biology of the Lewy body. J. Neuropathol. Exp. Neurol. 52 : 183 191.
11. Forno, L.S. 1996. Neuropathology of Parkinson's disease. J. Neuropathol. Exp. Neurol. 55 : 259 272.
12. Shults, C.W. 2006. Lewy bodies. Proc. Natl. Acad. Sci. USA 103 : 1661 1668.
13. Pollanen, M.S., C. Bergeron & L. Weyer. 1992. Detergent-insoluble cortical Lewy body fibrils share epitopes with neurofilament and tau. J. Neurochem. 58 : 1953 1956.
14. Iwatsubo, T., H. Yamaguchi, M. Fujimuro, et al. 1996. Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease. Am. J. Pathol. 148 : 1517 1529.
15. Gai, W.P., H.X. Yuan, X.Q. Li, et al. 2000. In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies. Exp. Neurol. 166 : 324 333.
16. Messner, D.J., G. Griffiths & S. Kornfeld. 1989. Isolation and characterization of membranes from bovine liver which are highly enriched in mannose 6-phosphate receptors. J. Cell. Biol. 108 : 2149 2162.
17. Marchand, S., F. Bignami, F. Stetzkowski-Marden, et al. 2000. The myristoylated protein rapsyn is cotargeted with the nicotinic acetylcholine receptor to the postsynaptic membrane via the exocytic pathway. Neurosci. 20 : 521 528.
18. Sexton, P.S., & R.J. Cenedella. 2002. Immunomagnetic capture of lens membrane fractions containing steroid binding protein. Biochem. Biophys. Res. Commun. 295 : 1027 1031.
19. El-Agnaf, O.M., S.A. Salem, K.E. Paleologou, et al. 2003. Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma. FASEB J. 13 : 1945 1947.
20. Roy, S., & L. Wolman. 1969. Ultrastructural observations in Parkinsonism. J. Pathol. 99 : 39 44.
21. Hayashida, K., S. Oyanagi, Y. Mizutani & M. Yokochi. 1993. An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism. Acta Neuropathol. (Berl.) 85 : 445 448.
22. Betarbet, R., T.B. Sherer, G. MacKenzie, et al. 2000. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 3 : 1301 1306.
23. Fornai, F., O.M. Schluter, P. Lenzi, et al. 2005b. Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. Proc. Natl. Acad. Sci. USA 102 : 3413 3418.
24. Sian, J., R. Hensiek, D. Senitz, et al. 1998. A novel technique for the isolation of Lewy bodies in brain. Acta Neuropathol. (Berl.) 96 : 111 115.
25. Oomori, Y., H. Tanaka, H. Iuchi, et al. 1993. Effect of fixation conditions on the granule morphology of rat antral gastrin cells: an ultrastructural and immunocytochemical study. Acta Histochem. 94 : 25 31.
26. Rømert, P. & M.E. Matthiessen. 1981. Swelling of mitochondria in immersion-fixed liver tissue: effect of various fixatives and of delayed fixation. Acta Anat. (Basel) 109 : 332 338.
27. Hunter, D.R., R.A. Haworth & J. H. Southard. 1976. Relationship between configuration, function, and permeability in calcium-treated mitochondria. J. Biol. Chem. 251 : 5069 5077.
28. Wakabayashi, T., M. Horiuchi, M. Sakaguchi, et al. 1984. Induction of megamitochondria in the rat liver by N-propyl alcohol and N-butyl alcohol. Acta Pathol. Jpn. 34 : 471 480.
29. Fornai, F., S. Piaggi, M. Gesi, et al. 2001. Subcellular localization of a glutathione-dependent dehydroascorbate reductase within specific rat brain regions. Neuroscience 104 : 15 31.