A novel technique for the isolation of Lewy bodies in brain

Acta Neuropathologica

Volumn 96, Issue 2, 1998, Pages 111-115

  Sian, J ^a   Hensiek, R ^b   Senitz, D ^a   Muench, G ^a   Jellinger, K ^c   Riederer, P ^a   Gerlach, M ^d  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Deutsche Dynal GmbH   (Germany)

^c LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^d RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Isolation; Lewy bodies; Neurodegeneration; Parkinson's disease

Indexed keywords

AGED; ARTICLE; BRAIN TISSUE; CASE REPORT; FEMALE; HUMAN; HUMAN TISSUE; LEWY BODY; NERVE DEGENERATION; NEUROPATHOLOGY; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; BRAIN; CEREBRAL CORTEX; CYTOLOGICAL TECHNIQUES; FEMALE; HUMANS; IMMUNOGLOBULIN G; LEWY BODIES; MENINGES; NERVE DEGENERATION;

EID: 0031819789     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050869     Document Type: Article

References (20)

1. Bancher C, Jellinger K, Eder H (1997) Selective visualisation of cortical LB by immunocytochemical double labelling: an aid in the diagnosis of combined pathologies. In: Iqbal K, Winblad B, Nishimura T, et al (eds) Alzheimer's disease: biology, diagnosis and therapeutics, vol 26. Wiley, New York, pp 185-188
2. Castellani R, Smith MA, Richely PL, et al (1996) Glycoxidation and oxidative stress in Parkinson's disease and diffuse Lewy body disease. Brain Res 737:195-200
3. Ciechanover A (1994) The ubiquitin-proteasome proteolytic pathway. Cell 79:13-21
4. Dale GE, Probst A, Luthert P, et al (1992) Relationship between Lewy bodies and pale bodies in Parkinson's disease. Acta Neuropathol 83:525-529
5. Duffy PE, Tennyson VM (1965) Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus coerleus in Parkinson's disease. J Neuropathol Exp Neurol 24:398-414
6. Forno LS, DeLanney LE, Irwin I, et al (1996) Electron microscopy of Lewy bodies in the amygdala-parahippocampal region. Adv Neurol 69:217-228
7. Galvin JE, Lee VMY, Baba M, et al (1997) Monoclonal antibodies to purified cortical Lewy bodies recognise the mid-size neurofilament subunit. Ann Neurol 42:595-603
8. Gibb WRG (1992) Neuropathology of Parkinson's disease and related syndromes. Neurol Clin 10:361-377
9. Gibb WRG, Lees AJ (1988) The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease. Neuropathol Appl Neurobiol 15:27-44
10. Hill WD, Arai M, Cohen JA, et al (1993) Neurofilament mRNA is reduced in Parkinson's disease substantia nigra pars compacta neurones. J Comp Neurol 329:328-336
11. Hirsch E, Ruberg M, Darderine M, et al (1985) Monoclonal antibodies raised against Lewy bodies in brain from patients with Parkinson's disease. Brain Res 345:374-378
12. Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, et al (1997) Purification and characterisation of Lewy body from the patients with diffuse Lewy body disease. Am J Pathol 148: 1517-1529
13. Lazzarini AM, Myers RH, Zimmerman TR, et al (1994) A clinical genetic study of Parkinson's disease: evidence for dominant transmission. Neurology 44:499-506
14. Lennox G, Lowe J, Morrell K, et al (1989) Anti-ubiquitin immunocytochemistry is more sensitive than coventional techniques in the detection of diffuse Lewy body disease. J Neurol Neurosurg Psychiatry 52:67-71
15. Lewy FH (1912) Paralysis agitans. I. Pathologische Anatomie. In: Lewandowsky M (ed) Handbuch der Neurologie Springer, Berlin, pp 920-933
16. Pellise A, Roig C, Barraquer-Bordas LI, et al (1996) Abnormal, ubiquinated cortical neurites in patients with diffuse Lewy body disease. Neurosci Lett 206:85-88
17. Pollanen MS, Bergeron C, Weyer L (1994) Characterisation of a shared epitome in cortical Lewy body fibrils and Alzheimer paired helical filaments. Acta Neuropathol 88:1-6
18. Polymeropoulos MH, Lavedan C, Leroy E, et al (1997) Mutation in the α-synuclein gene identified families with Parkinson's disease. Science 276:2045-2047
19. Tretiakoff C (1919) Contribution a l'étude de l'anatomie pathologique du locus niger de Soemmering avec quelques deductions relatives à pathogenic des troubles du tonus musculaire et de la maladie Parkinson. Doctoral thesis, Université Paris, Paris
20. Trojanowski JQ, Lee V (1998) Aggregation of neurofilament and α-synuclein proteins in Lewy bodies. Arch Neurol 55:151-152