Increased QT variability in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

European Journal of Neurology

Volumn 15, Issue 11, 2008, Pages 1216-1221

  Piccirillo, G ^a,c   Magri D ^a   Mitra, M ^a   Rufa, A ^b   Zicari, E ^b   Stromillo, M L ^b   De Stefano, N ^b   Dotti, M T ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c POLICLINICO UMBERTO I   (Italy)

Author keywords

Autonomic nervous system; CADASIL; QT variability; Sudden death

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN SCINTISCANNING; CADASIL; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL FEATURE; CONTROLLED STUDY; ELECTROCARDIOGRAM; FEMALE; FUNCTIONAL STATUS; HEART LEFT BUNDLE BRANCH BLOCK; HEART REPOLARIZATION; HEART VENTRICLE ARRHYTHMIA; HUMAN; LABORATORY DIAGNOSIS; MALE; MINI MENTAL STATE EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; PRIORITY JOURNAL; QT INTERVAL; RANKIN SCALE; RISK ASSESSMENT;

ADULT; AGED; ARRHYTHMIAS, CARDIAC; BRAIN; CADASIL; CEREBRAL ARTERIES; DEATH, SUDDEN, CARDIAC; ELECTROCARDIOGRAPHY; FEMALE; HEART CONDUCTION SYSTEM; HEART RATE; HEART VENTRICLES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PILOT PROJECTS; PREDICTIVE VALUE OF TESTS;

EID: 53549103874     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2008.02300.x     Document Type: Article

References (30)

1. Joutel A, Vahedi K, Corpechot C, et al. Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients. Lancet 1995 350 : 1511 1515.
2. Dichgans M, Mayer M, Uttner I, et al. Phenotypic spectrum of CADASIL: clinical findings in 102 cases. Annals of Neurology 1998 44 : 731 739.
3. Peters N, Herzog J, Opherk C, Dichgans M. A two years clinical follow-up in 80 CADASIL subjects: progressions patterns and implications for clinical trials. Stroke 2004 35 : 1603 1608.
4. Opherk C, Peters N, Herzog J, Luedtke R, Dichgans M. Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients. Brain 2004 127 : 2533 2539.
5. Task force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability. Standard of measurements, physiological interpretation and clinical use. Circulation 1996 93 : 1043 1065.
6. La Rovere MT, Pinna GD, Maestri R, et al. Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients. Circulation 2003 107 : 565 570.
7. Maison-Blanche P, Coumel P. Changes in repolarization dynamicity and the assessment of arrhythmic risk. Pacing and Clinical Electrophysiology 1997 20 : 2614 2624.
8. Atiga WL, Calkins H, Lawrence JH, Tomaselli GF, Smith JM, Berger RD. Beat-to-beat repolarization lability identifies patients at risk for sudden cardiac death. Journal of Cardiovascular Electrophysiology 1998 9 : 899 908.
9. Haigney MC, Zareba W, Gentlesk PJ, et al. QT interval variability and spontaneous ventricular tachycardia or fibrillation in the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II. Journal of the American College of Cardiology 2004 44 : 1481 1487.
10. Berger RD, Kasper EK, Baughman KL, Marban E, Calkins H, Tomaselli GF. Beat-to-beat QT interval variability novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation 1997 96 : 1557 1565.
11. Piccirillo G, Germanó G, Quaglione R, et al. QT interval and autonomic control in hypertensive subjects with left ventricular hypertrophy. Clinical Science 2002 102 : 363 371.
12. Bilchick K, Viitasalo M, Oikarinen L, et al. Temporal repolarization lability differences among genotyped patients with the long QT syndrome. American Journal of Cardiology 2004 94 : 1312 1316.
13. Piccirillo G, Magrì D, Matera S, et al. QT variability strongly predicts sudden cardiac death in asymptomatic subjects with mild or moderate left ventricular dysfunction: a prospective study. European Heart Journal 2007 28 : 1344 1350.
14. Magrì D, Sciomer S, Fedele F, et al. Increased QT variability in young asymptomatic patients with β-thalassemia major. European Journal of Haematology 2007 79 : 322 329.
15. Rufa A, Guideri F, Acampa M, et al. Cardiac autonomic nervous system and risk of arrhythmias in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL). Stroke 2007 38 : 276 280.
16. Lesnik Oberstein SA, Jukema JW, Van Duinen SG, et al. Myocardial infarction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL). Medicine (Baltimore) 2003 82 : 251 256.
17. Raghu C, Loubeyre C, Obadia E, Morice MC. Primary angioplasty in CADASIL. Catheterization and Cardiovascular Interventions 2003 59 : 235 237.
18. Davous P. CADASIL: a review with proposed diagnostic criteria. European Journal of Neurology 1998 5 : 219 233.
19. Bazett HC. An analysis of the time relations of electrocardiograms. Heart 1920 7 : 353 370.
20. Van Waesberghe JH, van Walerveen MA, Castelijns JA, et al. Pattern of lesion development in multiple sclerosis: longitudinal observations with T1-weighted spin-echo and magnetization transfer MR. American Journal of Neuroradiology 1998 19 : 675 683.
21. Tomaselli GF, Zipes DP. What causes sudden death in heart failure? Circulation Research 2004 95 : 754 763.
22. Piccirillo G, Santagada E, Viola E, et al. Autonomic modulation of heart rate and blood pressure in hypertensive subjects with symptoms of anxiety. Clinical Science 1998 95 : 43 52.
23. Piccirillo G, Viola E, Bucca C, et al. QT interval dispersion and autonomic modulation in subjects with anxiety. Journal of Clinical and Laboratory Medicine 1999 133 : 461 468.
24. Diedrich A, Jordan J, Shannon JR, Robertson D, Biaggioni I. Modulation of QT interval during autonomic nervous system blockade in humans. Circulation 2002 106 : 2238 2243.
25. Glickstein JS, Axelrod FB, Friedman D. Electrocardiographic repolarization abnormalities in familial dysautonomia: an indicator of cardiac autonomic dysfunction. Clinical Autonomic Research 1999 9 : 109 112.
26. Piccirillo G, Magrì D, Matera S, Marigliano V. Emotions that afflict the heart: influence of the autonomic nervous system on myocardial repolarization. Journal of Cardiovascular Electrophysiology 2008 19 : 185 187.
27. Piccirillo G, Magnanti M, Matera S, et al. Age and QT variability index during free breathing, controlled breathing and tilt in patients with chronic heart failure and healthy control subjects. Translational Research 2006 148 : 72 78.
28. Rufa A, Dotti MT, Franchi M, et al. Systolic blood pressure profile in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy. Stroke 2005 36 : 2554 2558.
29. Levy MN. Role of calcium in arrhythmogenesis. Circulation 1989 80 : 23 30.
30. 2+ release and Na/Ca exchange activity in hypertrophied canine ventricular myocytes: potential link between contractile adaptation and arrhythmogenesis. Circulation 2000 102 : 2137 2144.