Identification of novel potent inhibitors for ATP-phosphoribosyl transferase using three-dimensional structural database search technique

Quantitative Structure-Activity Relationships

Volumn 20, Issue 2, 2001, Pages 143-147

  Gohda, Keigo ^a,b,c   Ohta, Daisaku ^a   Kozaki, Akiko ^a   Fujimori, Ko ^a   Mori, Ichiro ^a   Kikuchi, Takeshi ^a  

^a CIBA GEIGY LTD   (Switzerland)

^b Computer Aided Molecular Modeling Research Center Kansai ^*  (Japan)

^c NONE   (Japan)

Author keywords

Bi substrate mimicking; Molecular modeling

Indexed keywords

AMINO ACIDS; BINDING SITES; COVALENT BONDS; ENZYME INHIBITION; MOLECULES; SEARCH ENGINES; SULFUR COMPOUNDS;

BI-SUBSTRATE MIMICING; BIOSYNTHESIS PATHWAYS; DATABASE SEARCHES; DIMENSIONAL DATABASE; HISTIDINE BIOSYNTHESIS; PHOSPHORIBOSYL TRANSFERASE; POTENT INHIBITOR; PRODUCT MOLECULES; SEARCH TECHNIQUE; STRUCTURAL DATABASE;

SUBSTRATES;

1 AMINO 2 METHYLNAPHTHALENESULFONIC ACID; 2,2 DITHIODIANILINE; 2,2' DITHIOBIS(1 AMINONAPHTHALENE); 4,4' DITHIODIANILINE; ADENOSINE TRIPHOSPHATE PHOSPHORIBOSYLTRANSFERASE; AMINO(CHLOROPHENYL)TRIAZOLOPYRIMIDINE; BTB 11668; MWP 01156; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ARABIDOPSIS; ARTICLE; DATA BASE; DRUG CLASSIFICATION; DRUG STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL;

EID: 0034864353     PISSN: 09318771     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3838(200107)20:2<143::AID-QSAR143>3.0.CO;2-R     Document Type: Article

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