Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis

Journal of Applied Physiology

Volumn 105, Issue 2, 2008, Pages 595-602

  Kan, Wen Hong ^a   Hsieh, Chi Hsun ^a,c   Schwacha, Martin G ^a   Choudhry, Mashkoor A ^a   Raju, Raghavan ^a   Bland, Kirby I ^a   Chaudry, Irshad H ^a,b  

^a Kentucky   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Hypoxia inducible factor 1 ; Inflammation; Inflammatory cytokines; Kupffer cells

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYALKENAL DERIVATIVE; ACETALDEHYDE; CELL DNA; FLUTAMIDE; GLUTATHIONE TRANSFERASE ALPHA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; MALONALDEHYDE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; RINGER LACTATE SOLUTION; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 3-NITROTYROSINE; ANTIANDROGEN; CHEMOKINE; CYTOKINE; DRUG DERIVATIVE; GLUTATHIONE TRANSFERASE; HIF1A PROTEIN, MOUSE; PEROXIDASE; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLEEDING; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; CYTOMETRY; DNA FRAGMENTATION; DRUG MECHANISM; ENZYME ACTIVITY; HEMORRHAGIC SHOCK; INFLAMMATION; INJURY; LAPAROTOMY; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RESUSCITATION; ANIMAL; BIOSYNTHESIS; C3H MOUSE; CELL SEPARATION; DRUG EFFECT; HEPATITIS; KUPFFER CELL; LIVER; LIVER CELL; METABOLISM; PATHOLOGY; WESTERN BLOTTING;

ANDROGEN ANTAGONISTS; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL SEPARATION; CHEMOKINES; CYTOKINES; DNA FRAGMENTATION; FLUTAMIDE; GLUTATHIONE TRANSFERASE; HEMORRHAGE; HEPATITIS; HEPATOCYTES; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KUPFFER CELLS; LIVER; MALE; MICE; MICE, INBRED C3H; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PEROXIDASE; TYROSINE;

EID: 53449097985     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00012.2008     Document Type: Article

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