A pulse-radiolysis approach to fast reductive cleavage of a disulfide bond to uncage enzyme activity

Free Radical Biology and Medicine

Volumn 45, Issue 9, 2008, Pages 1271-1278

  Milanesi, Lilia ^a   Tomas, Salvador ^b   Hunter, Christopher A ^a   Weinstein, Julia A ^a   Edge, Ruth ^c   Navaratnam, Suppiah ^d   Waltho, Jonathan P ^a   Best, Jonathan ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d DARESBURY LABORATORY   (United Kingdom)

Author keywords

Biological activity; Free radicals; Papain; Reductive pulse radiolysis; Uncaging

Indexed keywords

CYSTEINE; PAPAIN; THIOL;

ARTICLE; BIOCHEMISTRY; DISULFIDE BOND; ENZYME ACTIVITY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PULSE RADIOLYSIS;

BINDING SITES; CARICA; CATALYTIC DOMAIN; CYSTEINE; DISULFIDES; KINETICS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PAPAIN; PLANT EXTRACTS; PULSE RADIOLYSIS; SPECTROPHOTOMETRY; SULFHYDRYL COMPOUNDS;

EID: 53449093080     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.07.024     Document Type: Article

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