Mutation and copy number analysis of LNX1 and Numbl in nervous system tumors

Cancer Genetics and Cytogenetics

Volumn 186, Issue 2, 2008, Pages 103-109

  Blom, Tea ^a   Roselli, Annariikka ^a   Tanner, Minna ^b   Nupponen, Nina N ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF TAMPERE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

POLYGLUTAMINE; STEM CELL FACTOR RECEPTOR;

ARTICLE; CONTROLLED STUDY; EXON; GENE; GENE AMPLIFICATION; GENE MUTATION; GENE NUMBER; GENE SEQUENCE; GLIOMA; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; LNX1 GENE; MAJOR CLINICAL STUDY; MISSENSE MUTATION; NERVOUS SYSTEM TUMOR; NUMBL GENE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EXONS; GENE DOSAGE; GLIOMA; HUMANS; IN SITU HYBRIDIZATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUTATION; NERVOUS SYSTEM NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; UBIQUITIN-PROTEIN LIGASES;

ALIAS;

EID: 53449088231     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2008.07.003     Document Type: Article

References (33)

1. Galli R., Binda E., Orfanelli U., Cipelletti B., Gritti A., De Vitis S., Fiocco R., Foroni C., Dimeco F., and Vescovi A. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 64 (2004) 7011-7021
2. Singh S.K., Hawkins C., Clarke I.D., Squire J.A., Bayani J., Hide T., Henkelman R.M., Cusimano M.D., and Dirks P.B. Identification of human brain tumour initiating cells. Nature 432 (2004) 396-401
3. Joensuu H., Puputti M., Sihto H., Tynninen O., and Nupponen N.N. Amplification of genes encoding KIT, PDGFRα and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme. J Pathol 207 (2005) 224-231
4. Puputti M., Tynninen O., Sihto H., Blom T., Mäenpää H., Isola J., Paetau A., Joensuu H., and Nupponen N.N. Amplification of KIT, PDGFRA, VEGFR2, and EGFR in gliomas. Mol Cancer Res 4 (2006) 927-934
5. Ballas N., Battaglioli E., Atouf F., Andres M.E., Chenoweth J., Anderson M.E., Burger C., Moniwa M., Davie J.R., Bowers W.J., Federoff H.J., Rose D.W., Rosenfeld M.G., Brehm P., and Mandel G. Regulation of neuronal traits by a novel transcriptional complex. Neuron 31 (2001) 353-365
6. Su X., Kameoka S., Lentz S., and Majumder S. Activation of REST/NRSF target genes in neural stem cells is sufficient to cause neuronal differentiation. Mol Cell Biol 24 (2004) 8018-8025
7. Weller M., Berger H., Hartmann C., Schramm J., Westphal M., Simon M., Goldbrunner R., Krex D., Steinbach J.P., Ostertag C.B., Loeffler M., Pietsch T., and von Deimling A. German Glioma Network. Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker?. Clin Cancer Res 13 (2007) 6933-6937
8. Kunitz A., Wolter M., van den Boom J., Felsberg J., Tews B., Hahn M., Benner A., Sabel M., Lichter P., Reifenberger G., von Deimling A., and Hartmann C. DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in human gliomas. Brain Pathol 17 (2007) 363-370
9. Petersen P.H., Zou K., Hwang J.K., Jan Y.N., and Zhong W. Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature 419 (2002) 929-934
10. Petersen P.H., Zou K., Krauss S., and Zhong W. Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Nat Neurosci 7 (2004) 803-811
11. Verdi J.M., Schmandt R., Bashirullah A., Jacob S., Salvino R., Craig C.G., Program A.E., Lipshitz H.D., and McGlade C.J. Mammalian Numb is an evolutionarily conserved signaling adapter protein that specifies cell fate. Curr Biol 6 (1996) 1134-1145
12. Zhong W., Feder J.N., Jiang M.M., Jan L.Y., and Jan Y.N. Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron 17 (1996) 43-53
13. Rhyu M.S., Jan L.Y., and Jan Y.N. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell 76 (1994) 477-491
14. Guo M., Jan L.Y., and Jan Y.N. Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron 17 (1996) 27-41
15. Zhong W., Jiang M.M., Weinmaster G., Jan L.Y., and Jan Y.N. Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development 124 (1997) 1887-1897
16. Johnson J.E. Numb and Numblike control cell number during vertebrate neurogenesis. Trends Neurosci 26 (2003) 395-396
17. Pece S., Serresi M., Santolini E., Capra M., Hulleman E., Galimberti V., Zurrida S., Maisonneuve P., Viale G., and Di Fiore P.P. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 167 (2004) 215-221
18. Colaluca I.N., Tosoni D., Nuciforo P., Senic-Matuglia F., Galimberti V., Viale G., Pece S., and Di Fiore P.P. Numb controls p53 tumour suppressor activity. Nature 451 (2008) 76-80
19. Dho S.E., Jacob S., Wolting C.D., French M.B., Rohrschneider L.R., and McGlade C.J. The mammalian numb phosphotyrosine-binding domain: characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX. J Biol Chem 273 (1998) 9179-9187
20. Rice D.S., Northcutt G.M., and Kurschner C. The Lnx family proteins function as molecular scaffolds for Numb family proteins. Mol Cell Neurosci 18 (2001) 525-540
21. Chen J., Xu J., Zhao W., Hu G., Cheng H., Kang Y., Xie Y., and Lu Y. Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas. Int J Biochem Cell Biol 37 (2005) 2273-2283
22. Sihto H., Sarlomo-Rikala M., Tynninen O., Tanner M., Andersson L.C., Franssila K., Nupponen N.N., and Joensuu H. KIT and platelet-derived growth factor receptor alpha tyrosine kinase gene mutations and KIT amplifications in human solid tumors. J Clin Oncol 23 (2005) 49-57
23. Häyry V., Tanner M., Blom T., Tynninen O., Roselli A., Ollikainen M., Sariola H., Wartiovaara K., and Nupponen N.N. Copy number alterations of the polycomb gene BMI1 in gliomas. Acta Neuropathol 116 (2008) 97-102
24. Blom T., Tynninen O., Puputti M., Halonen M., Paetau A., Haapasalo H., Tanner M., and Nupponen N.N. Molecular genetic analysis of the REST/NRSF gene in nervous system tumors. Acta Neuropathol (Berl) 112 (2006) 483-490
25. Fuller G.N., Su X., Price R.E., Cohen Z.R., Lang F.F., Sawaya R., and Majumder S. Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16. Mol Cancer Ther 4 (2005) 343-349
26. Palm K., Metsis M., and Timmusk T. Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. Mol Brain Res 72 (1999) 30-39
27. Ooi L., and Wood I.C. Chromatin crosstalk in development and disease: lessons from REST. Nat Rev Genet 8 (2007) 544-554
28. Beghini A., Magnani I., Roversi G., Piepoli T., Di Terlizzi S., Moroni R.F., Pollo B., Fuhrman Conti A.M., Cowell J.K., Finocchiaro G., and Larizza L. The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines. Oncogene 22 (2003) 2581-2591
29. Nakamura M., Yang F., Fujisawa H., Yonekawa Y., Kleihues P., and Ohgaki H. Loss of heterozygosity on chromosome 19 in secondary glioblastomas. J Neuropathol Exp Neurol 59 (2000) 539-543
30. Artavanis-Tsakonas S., Rand M.D., and Lake R.J. Notch signaling: cell fate control and signal integration in development. Science 284 (1999) 770-776
31. Passos Gregorio S., Gattaz W., Tavares H., Kieling C., Timm S., Wang A., Berg Rasmussen H., Werge T., and Dias-Neto E. Analysis of coding-polymorphisms in NOTCH-related genes reveals Numbl poly-glutamine repeat to be associated with schizophrenia in Brazilian and Danish subjects. Schizophr Res 88 (2006) 275-282
32. Holtkamp N., Ziegenhagen N., Malzer E., Hartmann C., Giese A., and von Deimling A. Characterization of the amplicon on chromosomal segment 4q12 in glioblastoma multiforme. Neuro Oncol 9 (2007) 291-297
33. Rašin M.R., Gazula V.R., Breunig J.J., Kwan K.Y., Johnson M.B., Liu-Chen S., Li H.S., Jan L.Y., Jan Y.N., Rakic P., and Šestan N. Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci 10 (2007) 819-827