Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice

Epilepsia

Volumn 45, Issue 10, 2004, Pages 1176-1183

  Borowicz, Kinga K ^a   Luszczki, Jarogniew J ^a   Czuczwar, Stanislaw J ^a,b  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

Antiepileptic drugs; Drug interactions; Felbamate; Isobolography; Pentylenetetrazole seizures; Protective index

Indexed keywords

CLONAZEPAM; ETHOSUXIMIDE; FELBAMATE; PENTETRAZOLE; PHENOBARBITAL; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BRAIN LEVEL; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; FEMALE; INFORMATION PROCESSING; INTERMETHOD COMPARISON; ISOBOLOGRAPHY; LD 50; MOTOR COORDINATION; MOTOR DYSFUNCTION; MYOCLONUS SEIZURE; NONHUMAN; PATHOPHYSIOLOGY; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS;

ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; CLONAZEPAM; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; EPILEPSIES, MYOCLONIC; ETHOSUXIMIDE; FEMALE; HUMANS; LETHAL DOSE 50; MICE; MOTOR ACTIVITY; NEUROTOXICITY SYNDROMES; PENTYLENETETRAZOLE; PHENOBARBITAL; PROPYLENE GLYCOLS; SEIZURES; VALPROIC ACID;

EID: 5344234859     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0013-9580.2004.09604.x     Document Type: Article

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