Felbamate and meprobamate: A comparison of their anticonvulsant properties

Epilepsy Research

Volumn 27, Issue 3, 1997, Pages 151-164

  Frey, Hans Hasso ^a   Bartels, Imke ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Absence epilepsy; Amygdala kindled rats; MES; Neurotoxicity; PTZ seizure threshold test; Reflex epilepsy in gerbils

Indexed keywords

ANTICONVULSIVE AGENT; FELBAMATE; MEPROBAMATE;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL TISSUE; ANTICONVULSANT THERAPY; ARTICLE; DOSE RESPONSE; EPILEPSY; FEMALE; GERBIL; HUMAN; LD 50; MALE; NEUROTOXICITY; PRIORITY JOURNAL; RAT; TRANQUILIZING ACTIVITY;

ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; ELECTROSHOCK; EPILEPSY, ABSENCE; FEMALE; GERBILLINAE; KINDLING, NEUROLOGIC; MALE; MEPROBAMATE; PROPYLENE GLYCOLS; RATS; RATS, WISTAR;

EID: 0030751105     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(97)01021-8     Document Type: Article

References (28)

1. Adusumalli, V.E., Gilchrist, J.R., Kucharczyk, N. and Sofia, R.D., Pharmacokinetics of the new antiepileptic drug felbamate in pediatric and adult beagle dogs, Epilepsia, 33 (1992) 955-960.
2. Bebin, E.M., Sofia, R.D. and Dreifuss, F.E., Felbamate toxicity. In: R.H. Levy, R.H. Mattson and B.S. Meldrum (Eds.), Antiepileptic Drugs, 4th Edn, Raven Press, New York, 1995, pp. 823-827.
3. Berger, F.M., The pharmacological properties of 2-methyl-2-n-propyl-1,3-propanediol dicarbamate (Miltown), a new interneuronal blocking agent, J. Pharmacol. Exp. Ther., 112 (1954) 413-423.
4. Berger, F.M., Handley, C.D., Ludwig, B.J. and Lynes, T.E., Central depressant and anticonvulsant activity of compounds isomeric with 2-methyl-2-n-propyl-1,3-propanediol dicarbamate (Miltown), J. Pharmacol. Exp. Ther., 116 (1956) 337-342.
5. Boissier, J.-R., Tardy, J. and Diverres, J.-C., Une nouvelle méthode simple pour explorer l'action 'tranquillisante': le test de la cheminée, Med. Exp. (Basel) 3 (1960) 81-83.
6. Chin, L. and Swinyard, E.A., Pentylenetetrazol seizure threshold in meprobamate- and phenaglycodol-treated mice, J. Am. Pharm. Assoc. Sci. Ed., 48 (1959) 6-8.
7. Coenen, A.M., Drinkenburg, W.H., Inoue, M. and Van Luijtelaar, E.L., Genetic models of absence epilepsy, with emphasis on the WAG/Rij strain of rats, Epilepsy Res., 12 (1992) 75-86.
8. Dunham, N.W. and Miya, T.S., A note on a simple apparatus for detecting neurological deficit in rats and mice, J. Am. Pharm. Assoc. Sci. Ed., 46 (1957) 208-209.
9. Fink, G.B. and Swinyard, E.A., Modification of maximal audiogenic and electroshock seizures in mice by psychopharmacologic drugs, J. Pharmacol. Exp. Ther., 127 (1959) 318-324.
10. Frey, H.-H., Induction of seizures by air blast in gerbils: stimulus duration/effect relationship, Epilepsy Res., 1 (1987) 262-264.
11. Frey, H.-H., Löscher, W., Reiche, R. and Schultz, D., Anticonvulsant potency of common antiepileptic drugs in the gerbil, Pharmacology, 27 (1983) 330-335.
12. Litchfield, J.T. and Wilcoxon, R., A simplified method of evaluating dose-effect experiments, J. Pharmacol. Exp. Ther., 96 (1949) 99-113.
13. Löscher, W. and Frey, H.-H., Evaluation of anticonvulsant drugs in gerbils with reflex epilepsy, Arzneimittel-Forsch., 34 (1984) 1484-1488.
14. Loskota, W.J., Lomax, P. and Rich, S.T., The gerbil as a model for the study of epilepsy: seizure habituation and seizure patterns, Proc. West. Pharmacol. Soc., 15 (1972) 189-194.
15. McNamara, J.O., Kindling: an animal model of complex partial epilepsy, Ann. Neurol., 16 (1984) S72-S76.
16. Meyler, L. and Herxheimer, A., Side effects of drugs, Vol. VI, Exerpta Medica, Amsterdam, 1968, pp. 60.
17. Perhach, J.L. and Shumaker, R.C., Felbamate. absorption, distribution, and excretion, In: R.H. Levy, R.H. Mattson and B.S. Meldrum (Eds.), Antiepileptic Drugs, 4th Edn, Raven Press, New York, 1995, pp. 807-812.
18. Racine, R., Modification of seizure activity by electrical stimulation. II. Motor seizure, Electroencephalogr. Clin. Neurophysiol. 32 (1972) 295-299.
19. Rail, T.W., Hypnotics and sedatives: ethanol. In: A. Goodman Gilman, T.W. Rail, A.S. Nies, P. Taylor (Eds.), The Pharmacological Basis of Therapeutics, 8th Edn, Pergamon Press, New York, 1990, pp. 345-382.
20. Sofia, R.D., Felbamate. Mechanism of action. In: R.H. Levy, R.H. Mattson and B.S. Meldrum (Eds.), Antiepileptic Drugs, 4th Edn, Raven Press, New York, 1995, pp. 791-797.
21. Swinyard, E.A., Brown, W.C. and Goodman, L.S., Comparative assays of antiepileptic drugs in mice and rats, J. Pharmacol. Exp. Ther., 106 (1952) 319-330.
22. Swinyard, E.A., Sofia, R.D. and Kupferberg, H.J., Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats, Epilepsia, 27 (1986) 27-34.
23. Theodore, W.H., Jensen, P.K. and Kwan, R.M.F., Felbamate. Clinical use. In: R.H. Levy, R.H. Mattson and B.S. Meldrum (Eds.), Antiepileptic Drugs, 4th Edn, Raven Press, New York, 1995, pp. 817-822.
24. Vergnes, M., Marescaux, C., Micheletti, G., Reis, J., Depaulis, A., Rumbach, L. and Warter, J.M., Spontaneous paroxysmal electroclinical patterns in the rat: a model of generalized non-convulsive epilepsy, Neurosci. Lett. 33 (1982) 97-101
25. Voits, M. and Frey, H.-H., Stimulation-dependent effect of antiepileptic drugs in amygdala kindled rats on both seizure score and duration of afterdischarges, Pharmacol. Toxcicol., 75 (1994) 54-61.
26. Wahle, H. and Frey, H.-H., Development of tolerance to the anticonvulsant effect of valproate but not to ethosuximide in a rat model of absence epilepsy, Eur. J. Pharmacol. 181 (1990) 1-8.
27. White, H.S., Wolf, E.A., Swinyard, E.A., Skeen, G.A. and Sofia, R.D., A neuropharmacological evaluation of felbamate as a novel anticonvulsant, Epilepsia, 33 (1992) 564-572.
28. Wigger, D., Der Einfluß sechs klinisch gebräuchlicher Antiepileptika auf die Krampfentwicklung und Bildung eines epileptischen Spiegelfocus im Amygdala-Kindling-Modell der Ratte. Thesis, Freie Universität Berlin, School of Veterinary Medicine, 1994