Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5631-5634

  Yan, Hongbin ^a   Wang, Xiaolu ^a   KuoLee, Rhonda ^b   Chen, Wangxue ^b  

^a BROCK UNIVERSITY   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

cdiGMP; Immunostimulation; Phosphorothioate; Vaccine adjuvant

Indexed keywords

3',5' CYCLIC DIGUANYLIC ACID; 3',5' CYCLIC DIGUANYLIC ACID S1 DERIVATIVE; 3',5' CYCLIC DIGUANYLIC ACID S2 DERIVATIVE; BIPHOSPHOROTHIOATE DERIVATIVE; CYCLIC GMP; INTERLEUKIN 12P40; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOPHOSPHOROTHIOATE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PHOSPHOROTHIOIC ACID DERIVATIVE; RANTES; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; IMMUNOSTIMULATION; INFLAMMATORY CELL; LUNG LAVAGE; MOUSE; NEUTROPHIL; NONHUMAN;

BRONCHI; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; IMMUNE SYSTEM; INFLAMMATION; MODELS, CHEMICAL; NEUTROPHILS; PHOSPHATES; PHOSPHONIC ACIDS; VACCINES;

EID: 53349177790     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.088     Document Type: Article

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