Polymorphisms in uncoupling protein, melanocortin 3 receptor, melanocortin 4 receptor, and pro-opiomelanocortin genes and association with production traits in a commercial broiler line

Poultry Science

Volumn 87, Issue 10, 2008, Pages 2073-2086

  Bottje, W ^a   Sharma, P ^b   Okimoto, R ^c  

^a UNIVERSITY OF ARKANSAS   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Cobb Vantress Inc ^*  (United States)

Author keywords

Feed conversion ratio; Polymorphism; Production trait

Indexed keywords

AVES;

EID: 53349175695     PISSN: 00325791     EISSN: 15253171     Source Type: Journal    
DOI: 10.3382/ps.2008-00060     Document Type: Article

References (31)

1. Bailes, S. M., J. J. Devers, J. D. Kirby, and D. D. Rhoads. 2007. An inexpensive, simple protocol for DNA isolation from blood for high-throughput genotyping by polymerase chain reaction or restriction endonuclease digestion. Poult. Sci. 86:102-106.
2. Balasubramanian, S., Y. Xia, E. Freinkman, and M. Gerstein. 2005. Sequence variation in G-protein-coupled receptors: Analysis of single nucleotide polymorphisms. Nucleic Acids Res. 33:1710-1721.
3. Challis, B. G., L. E. Pritchard, J. W. M. Creemers, J. Delplanque, J. M. Keogh, J. Luan, N. J. Wareham, G. S. H. Yeo, S. Bhattacharyya, P. Froguel, A. White, I. S. Farooqi, and S. O'Rahilly. 2002. A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Hum. Mol. Genet. 11:1997-2004.
4. Chen, A. S., D. J. Marsh, M. E. Trumbauer, E. G. Frazier, X. M. Guan, H. Yu, C. I. Rosenblum, A. Vongs, Y. Feng, L. H. Cao, J. M. Metzger, A. M. Strack, R. E. Camacho, T. N. Mellin, C. N. Nunes, W. Min, J. Fisher, S. Gopal-Truter, D. E. MacIntyre, H. Y. Chen, and L. H. T. Van der Ploeg. 2000. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat. Genet. 26:97-102.
5. Collin, A., M. Taouis, J. Buyse, N. B. Ifuta, V. M. Darras, P. Van As, R. D. Malheiros, V. M. B. Moraes, and E. Decuypere. 2003. Thyroid status, but not insulin status, affects expression of avian uncoupling protein mRNA in chicken. Am. J. Physiol. Endocrinol. Metab. 284:E771-E777.
6. Cone, R. D., D. S. Lu, S. Koppula, D. I. Vage, H. Klungland, B. Boston, W. B. Chen, D. N. Orth, C. Pouton, and R. A. Kesterson. 1996. The melanocortin receptors: Agonists, antagonists, and the hormonal control of pigmentation. Recent Prog. Horm. Res. 51:287-318.
7. Girvitz, S. C., S. Bacchetti, A. J. Rainbow, and F. L. Graham. 1980. A rapid and efficient procedure for the purification of DNA from agarose gels. Anal. Biochem. 106:492-496.
8. Holder, J. R., and C. Haskell-Luevano. 2004. Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies. Med. Res. Rev. 24:325-356.
9. Klingenberg, M., and S. G. Huang. 1999. Structure and function of the uncoupling protein from brown adipose tissue. Biol. Biophys. Acta. 1415:271-296.
10. Kolath, W. H., M. S. Kerley, J. W. Golden, S. A. Shahid, and G. S. Johnson. 2006. The relationships among mitochondrial uncoupling protein 2 and 3 expression, mitochondrial deoxyribonucleic acid single nucleotide polymorphisms, and residual feed intake in Angus steers. J. Anim. Sci. 84:1761-1766.
11. Krude, H., H. Biebermann, and A. Gruters. 2003. Mutations in the human proopiomelanocortin gene. Ann. N. Y. Acad. Sci. 994:233-239.
12. Krude, H., H. Biebermann, W. Luck, R. Horn, G. Brabant, and A. Gruters. 1998. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat. Genet. 19:155-157.
13. Lee, A., B. K. Rana, H. H. Schiffer, N. J. Schork, M. R. Brann, P. A. Insel, and D. M. Weiner. 2003. Distribution analysis of nonsynonymous polymorphisms within the G-protein-coupled receptor gene family. Genomics 81:245-248.
14. Liu, S., S. Z. Wang, Z. H. Li, and H. Li. 2007. Association of single nucleotide polymorphism of chicken uncoupling protein gene with muscle and fatness traits. J. Anim. Breed. Genet. 124:230-235.
15. Lu, D. S., D. I. Vage, and R. D. Cone. 1998. A ligand-mimetic model for constitutive activation of the melanocortin-1 receptor. Mol. Endocrinol. 12:592-604.
16. Ojano-Dirain, C., N. Pumford, M. Toyomizu, and W. Bottje. 2007. Association of mitochondrial function and feed efficiency. Jpn. Poult. Sci. 44:221-237.
17. Raffin-Sanson, M. L., and J. Bertherat. 2001. Mc3 and Mc4 receptors: Complementary role in weight control. Eur. J. Endocrinol. 144:207-208.
18. Raimbault, S., S. Dridi, F. Denjean, J. Lachuer, E. Couplan, F. Bouillaud, A. Bordas, C. Duchamp, M. Taouis, and D. Ricquier. 2001. An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds. Biochem. J. 353:441-444.
19. Robbins, L. S., J. Nadeau, K. Johnson, M. Kelly, L. Roselli-Rehfuss, E. Baack, K. Mountjoy, and R. Cone. 1993. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72:827-834.
20. Sadee, W., E. Hoeg, J. Lucas, and D. X. Wang. 2001. Genetic variations in human G protein-coupled receptors: Implications for drug therapy. AAPS Pharm. Sci. 3:E22.
21. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory Press, Woodbury, NY.
22. Skinner-Noble, D. O., and R. G. Teeter. 2004. Components of feed efficiency in broiler breeding stock: Influence of water intake and gastrointestinal contents. Poult. Sci. 83:1260-1263.
23. Srinivasan, S., C. Lubrano-Berthelier, C. Govaerts, F. Picard, P. Santiago, B. R. Conklin, and C. Vaisse. 2004. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J. Clin. Invest. 114:1158-1164.
24. Takeuchi, S., S. Takahashi, R. Okimoto, H. B. Schioth, and T. Boswell. 2003. Avian melanocortin system: Alpha-MSH may act as an autocrine/paracrine hormone - A minireview. Ann. N. Y. Acad. Sci. 994:366-372.
25. Takeuchi, S., K. Teshigawara, and S. Takahashi. 2000. Widespread expression of Agouti-related protein (AGRP) in the chicken: A possible involvement of AGRP in regulating peripheral melanocortin systems in the chicken. Biochim. Biophys. Acta 1496:261-269.
26. Talbot, D. A., C. Duchamp, B. Rey, N. Hanuise, J. L. Rouanet, B. Sibille, and M. D. Brand. 2004. Uncoupling protein and ATP/ADP carrier increase mitochondrial proton conductance after cold adaptation of king penguins. J. Physiol. 558:123-135.
27. Tao, Y. X., and D. L. Segaloff. 2003. Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity. Endocrinology 144:4544-4551.
28. Vignal, A., D. Milan, M. SanCristobal, and A. Eggen. 2002. A review on SNP and other types of molecular markers and their use in animal genetics. Genet. Sel. Evol. 34:275-305.
29. Wardlaw, S. L. 2001. Obesity as a neuroendocrine disease: Lessons to be learned from proopiomelanocortin and melanocortin receptor mutations in mice and men. J. Clin. Endocrinol. Metab. 86:1442-1446.
30. Williams, D. L., R. R. Bowers, T. J. Bartness, J. M. Kaplan, and H. J. Grill. 2003. Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat. Endocrinology 144:4692-4697.
31. Yang, Y. K., and C. M. Harmon. 2003. Recent developments in our understanding of melanocortin system in the regulation of food intake. Obes. Rev. 4:239-248.