Is the genotoxic effect of magnetic resonance negligible? Low persistence of micronucleus frequency in lymphocytes of individuals after cardiac scan

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 645, Issue 1-2, 2008, Pages 39-43

  Simi, Silvana ^a   Ballardin, Michela ^a   Casella, Marta ^a   De Marchi, Daniele ^a   Hartwig, Valentina ^a,b   Giovannetti, Giulio ^a   Vanello, Nicola ^a,b   Gabbriellini, Sabrina ^a   Landini, Luigi ^a,b   Lombardi, Massimo ^a  

^a INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Genotoxic effect; Magnetic resonance; Micronuclei

Indexed keywords

BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA STRUCTURE; DOSE RESPONSE; ECHOCARDIOGRAPHY; ELECTROMAGNETIC FIELD; ENERGY ABSORPTION; FEMALE; GENOTYPE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE; LYMPHOCYTE CULTURE; MALE; MICRONUCLEUS; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; ROOM TEMPERATURE;

ADULT; AGED; FEMALE; HEART DISEASES; HUMANS; LYMPHOCYTES; MAGNETIC RESONANCE IMAGING; MAGNETICS; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MIDDLE AGED; MUTATION;

EID: 53349164381     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2008.08.011     Document Type: Article

References (38)

1. Franco G., Perduri R., and Murolo A. Health effects of occupational exposure to static magnetic fields used in magnetic resonance imaging: a review. Med. Lav. 99 (2008) 16-28
2. De Vocht F., van Wendel de Jode B., Engels H., and Kromhout H. Neurobehavioral effects among subjects exposed to high static and gradient magnetic fields from a 1.5 Tesla MRI system: a case-crossover pilot study. Magn. Reson. Med. 50 (2003) 670-674
3. Kangarlu A., and Robitaille P.M.L. Biological effects and health implications in magnetic resonance imaging. Concepts Magn. Reson. 12 (2000) 321-359
4. Leszczynski D. Rapporteur report: cellular, animal and epidemiological studies of the effects of static magnetic fields relevant to human health. Prog. Biophys. Mol. Biol. 87 (2005) 247-253
5. Carnes K.I., and Magin R.L. Effects of in uterus exposure to 4.7 T MR imaging conditions on fetal growth and testicular development in mouse. J. Magn. Reson. Imaging 14 (1996) 263-274
6. High W., Sikoraj, Ugurbil K., and Garwood M. Subchronic in vivo effects of a high static magnetic field in rats. J. Magn. Reson. Imaging 12 (2000) 122-139
7. Saito K., Suzuki H., and Suzuki K. Teratogenic effects of static magnetic fields on mouse fetuses. Reprod. Toxicol. 22 (2006) 118-124
8. Rodegerdts E.A., Gronewaller E.F., Kehlbach R., Roth P., Wiskirchen J., Gebert R., and Claussen C.I. In vitro evaluation of teratogenic effects by time-varying MR Gradient fields on fetal human fibroblasts. J. Magn. Reson. Imaging 12 (2000) 150-156
9. Schiffer I.B., Schreiber W.G., Graf R., et al. No influence of magnetic fields on cell cycle progression using condition relevant for patients during MRI. Bioelectromagnetics 24 (2003) 241-250
10. Repacholi M.H., and Greenebaum B. Interaction of static and extremely low frequency electric and magnetic fields with living systems: health effects and research needs. Bioelectromagnetics 20 (1999) 133-160
11. Greenland S., Sheppard A.R., Kaune W.T., Poole C., Kelsh M.A., and Childhood Leukemia-EMF Study Group. A pooled analysis of magnetic fields, wire codes, and childhood leukemia. Epidemiology 11 (2000) 624-634
12. Vijayalaxmi, and Obe G. Controversial cytogenetic observations in mammalian somatic cells exposed to extremely low frequency electromagnetic radiation: a review and future research recommendations. Bioelectromagnetics 26 (2005) 412-430
13. Kirsch-Volders M., Elhajouji A., Cundari E., and Van Hummelen P. The in vitro micronucleus test: a multi-endpoint assay to detect simultaneously mitotic delay, apoptosis, chromosome breakage, chromosome loss and non-disjunction. Mutat. Res. 392 (1997) 19-30
14. Casella M., Lucarelli M., Simili M., et al. Spontaneous chromosome loss and colcemid resistance in lymphocytes from patients with myotonic dystrophy type 1. Cytogenet. Genome Res. 100 (2003) 224-229
15. Bonassi S., Znaor A., Ceppi M., et al. An increased micronucleus frequency in peripheral blood lymphocytespredicts the risk of cancer in humans. Carcinogenesis 28 (2007) 625-631
16. Fenech M. The in vitro micronucleus technique. Mutat. Res. 20 (2000) 81-95
17. Fenech M. The cytokinesis-block micronucleus technique and its application to genotoxicity studies in human populations. Environ. Health Perspect. 101 Suppl. 3 (1993) 101-107
18. Jin J. Electromagnetic Analysis and Design in Magnetic Resonance Imaging (1999), CRC Press, Boca Raton, FL
19. McRobbie D.W., Moore E.A., Graves M.J., and Prince M.R. MRI-From Picture to Proton (2006), Cambridge University Press, Cambridge, New York
20. Bottomley P.A., Redington R.W., Edelstein W.A., and Schenck J.F. Estimating radiofrequency power deposition in body NMR imaging. Magn. Reson. Med. 2 (1985) 336-349
21. Hartwig V., Giovannetti G., Vanello N., Landini L., and Benassi A. Radiofrequency measurement of liquid sample dielectric properties for magnetic resonance applications. Int. J. Biomed. Eng. Technol. 1 (2007) 158-171
22. Kirkland D.J. Statistical Evaluation of Mutagenicity Test Data (1989), Cambridge University Press, Cambridge, UK
23. Dardano A., Ballardin M., Ferdeghini M., Lazzeri E., Traino C., Caraccio N., Mariani G., Barale R., and Monzani F. Anticlastogenic effect of Ginkgo biloba extract in Graves' disease patients receiving radioiodine therapy. J. Clin. Endocrinol. Metab. 92 (2007) 4286-4292
24. Asanami S., and Shimono K. High body temperature induces micronuclei in mouse bone marrow. Mutat. Res. 390 (1997) 79-83
25. Ivancsits S., Diem E., Pilger A., Rudiger H.W., and Jahn O. Induction of DNA strand breaks by intermittent exposure to ELF-EMF in human diploid fibroblasts. Mutat. Res. 519 (2002) 1-13
26. Parvez Z., Kormano M., Moncada R., and Eklund R. Contrast media-induced chromosomal damage in human lympocytes cultures. Invest. Radiol. 21 (1986) 864-869
27. Hande M.P., Boei J.J., and Natarajan A.T. Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridisation. II. Micronuclei. Int. J. Radiat. Biol. 70 (1996) 375-383
28. Ramirez M.J., Suralles J., Puerto S., Creus A., and Marcos R. Low persistence of radiation induced centromere positive and negative micronuclei in culturedhuman cells. Mutat. Res. 440 (1999) 163-169
29. Mailhes J.B., Young D., Marino A.A., and London S.N. Electromagnetic fields enhance chemically-induced hyperploidy in mammalian oocytes. Mutagenesis 12 (1997) 347-351
30. Cho Y.H., and Chung H.W. The effects of extremely low frequency electromagnetic fields on the frequency of micronuclei and sister chromatid exchange in human lymphocytes induced by benzo(a)pyrene. Toxicol. Lett. 143 (2003) 37-44
31. Mairs R.J., Hughes K., Fizsimmons S., et al. Microsatellite analysis for determination of the mutagenicity of ELF-electromagnetic fields and ionising radiation in vitro. Mutat. Res. 626 (2007) 34-41
32. Magin R.L., Lee J.K., Klintsova A., Carnes K.I., and Dunn F. Biological effects of long-duration, high-field (4T) MRI on growth and development in the mouse. J. Magn. Reson. Imaging 12 (2000) 140-149
33. Zeni O., Bersani F., and Scarfì M.R. Radiological workers sensitivity to 50 Hz pulsed magnetic fields: preliminary results. Radiat. Environ. Biophys. 41 (2002) 275-279
34. Scarfì M.R., Prisco F., Lioi M.B., et al. Cytogenetic effects induced by extremely low frequency pulsed magnetic fields in lymphocytes from Turner's syndrome subjects. Bioelectrochem. Bioenerg. 43 (1997) 221-226
35. Bonassi S., Znaor A., Ceppi M., Lando C., Chang W.P., Holland N., Kirsch-Volders M., Zeiger E., Ban S., Barale R., Bigatti M.P., Bolognesi C., Cebulska-Wasilewska A., Fabianova E., Fucic A., Hagmar L., Joksic G., Martelli A., Migliore L., Mirkova E., Scarfi M.R., Zijno A., Norppa H., and Fenech M. An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 28 3 (2007) 625-631
36. Andreassi M.G., Venneri L., and Picano E. Cardiac imaging: the biological effects of diagnostic cardiac ultrasound. Prog. Biophys. Mol. Biol. 93 (2007) 399-410
37. Andreassi M.G., Ait-Ali L., Botto N., Manfredi S., Mottola G., and Picano E. Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease. Eur. Heart J. 27 (2007) 2703-2708
38. Picano E. Sustainability of medical imaging. BMJ 328 (2004) 578-580