Use of the X-ray structure of the β2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5391-5395

  Sabio, Michael ^a   Jones, Kenneth ^a   Topiol, Sid ^a  

^a LUNDBECK RESEARCH USA   (United States)

Author keywords

2 Adrenergic receptor; Carvedilol; Corazolol; GPCR; High throughput docking; Timolol

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CARVEDILOL; CORAZOLOL; G PROTEIN COUPLED RECEPTOR; RADIOLIGAND; TIMOLOL; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER MODEL; CRYSTAL STRUCTURE; DATA BASE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR DOCKING; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CARBAZOLES; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG DISCOVERY; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PENTYLENETETRAZOLE; PROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA-2; X-RAYS;

EID: 53349102957     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.046     Document Type: Article

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