The effect of sivelestat sodium on post-cardiopulmonary bypass acute lung injury in a neonatal piglet model

Interactive Cardiovascular and Thoracic Surgery

Volumn 7, Issue 5, 2008, Pages 785-788

  Ando, Makoto ^a   Murai, Tatsuya ^b   Takahashi, Yukihiro ^a  

^a SAKAKIBARA HEART INSTITUTE   (Japan)

^b Sakakibara Heart Institute   (Japan)

Author keywords

Cardiopulmonary bypass; Neutrophil activation; Sivelestat sodium; Systemic inflammatory response

Indexed keywords

INTERLEUKIN 8; PLACEBO; SIVELESTAT;

ACUTE LUNG INJURY; ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL OXYGEN TENSION; ARTICLE; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; HEART MUSCLE ISCHEMIA; HISTOPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALS; ANIMALS, NEWBORN; CARDIOPULMONARY BYPASS; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; GLYCINE; LEUKOCYTE ELASTASE; LUNG; LUNG DISEASES; NEUTROPHIL ACTIVATION; NEUTROPHILS; SERINE PROTEINASE INHIBITORS; SULFONAMIDES; SWINE; TIME FACTORS;

EID: 53349102592     PISSN: 15699293     EISSN: None     Source Type: Journal    
DOI: 10.1510/icvts.2008.177576     Document Type: Article

References (15)

1. Gilliland HE, Armstrong MA, McMurray TJ. The inflammatory response to pediatric cardiac surgery: correlation of granulocyte adhesion molecule expression with postoperative oxygenation. Anesth Analg 1999;89:1188-1191.
2. Kodama T, Yukioka H, Kato T, Kato N, Hato F, Kitagawa S. Neutrophil elastase as a predicting factor for development of acute lung injury. Intern Med 2007;46:699-704.
3. Matsuzaki K, Hiramatsu Y, Homma S, Sato S, Shigeta O, Sakakibara Y. Silvelestat reduces inflammatory mediators and preserves neutrophil deformability during simulated extracorporeal circulation. Ann Thorac Surg 2005;80:611-617.
4. Ovechkin AV, Lominadze D, Sedoris KC, Robinson TW, Tyagi SC, Roberts AM. Lung ischemia-reperfusion injury: implications of oxidative stress and platelet-arteriolar wall interactions. Arch Physiol Biochem 2007;113:1-12.
5. Kozik DJ, Tweddell JS. Characterizing the inflammatory response to cardiopulmonary bypass in children. Ann Thorac Surg 2006;81:S2347-S2354.
6. Griese M, Wilnhammer C, Jansen S, Rinker C. Cardiopulmonary bypass reduces pulmonary surfactant activity in infants. J Thorac Cardiovasc Surg 1999;118:237-244.
7. Bream-Rouwenhorst HR, Beltz EA, Ross MB, Moores KG. Recent developments in the management of acute respiratory distress syndrome in adults. Am J Health Syst Pharm 2008;65:29-36.
8. Gessler P, Hohl V, Carrel T, Pfenninger J, Schmid ER, Baenziger O, Prètre R. Administration of steroids in pediatric cardiac surgery: impact on clinical outcome and systemic inflammatory response. Pediatr Cardiol 2005;26:595-600.
9. Paśnik J, Siniewicz K, Moll JA, Moll J, Baj Z, Sysa A, Zeman K. Effect of cardiopulmonary bypass on neutrophil activity in pediatric open-heart surgery. Arch Immunol Ther Exp (Warsz) 2005;53:272-277.
10. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 1989;320:365-375.
11. Ryugo M, Sawa Y, Takano H, Matsumiya G, Iwai S, Ono M, Hata H, Yamauchi T, Nishimura M, Fujino Y, Matsuda H. Effect of a polymorphonuclear elastase inhibitor (sivelestat sodium) on acute lung injury after cardiopulmonary bypass: findings of a double-blind randomized study. Surg Today 2006;36:321-326.
12. Endo S, Sato N, Yaegashi Y, Suzuki Y, Kojika M, Yamada Y, Yoshida Y, Nakadate T, Aoki H, Inoue Y. Sivelestat sodium hydrate improves septic acute lung injury by reducing alveolar dysfunction. Res Commun Mol Pathol Pharmacol 2006;119:53-65.
13. Suda K, Kitagawa Y, Ozawa S, Miyasho T, Okamoto M, Saikawa Y, Ueda M, Yamada S, Tasaka S, Funakoshi Y, Hashimoto S, Yokota H, Maruyama I, Ishizaka A, Kitajima M. Neutrophil elastase inhibitor improves postoperative clinical courses after thoracic esophagectomy. Dis Esophagus 2007;20:478-486.
14. Wakayama F, Fukuda I, Suzuki Y, Kondo N. Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model. Ann Thorac Surg 2007;83:153-160.
15. Ishizaka A, Watanabe M, Yamashita T, Ogawa Y, Koh H, Hasegawa N, Nakamura H, Asano K, Yamaguchi K, Kotani M, Kotani T, Morisaki H, Takeda J, Kobayashi K, Ogawa S. New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome. Crit Care Med 2001;29:896-898.