Mechanisms of heartburn

Nature Clinical Practice Gastroenterology and Hepatology

Volumn 5, Issue 7, 2008, Pages 383-392

  Ang, Daphne ^a   Sifrim, Daniel ^b   Tack, Jan ^b  

^a CHANGI GENERAL HOSPITAL   (Singapore)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; OMEPRAZOLE; PROTON PUMP INHIBITOR; STOMACH SECRETION INHIBITOR; VANILLOID RECEPTOR 1;

ANXIETY; BARRETT ESOPHAGUS; BILE REFLUX; CHEMORECEPTOR; COMORBIDITY; DEPRESSION; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG RESPONSE; ESOPHAGEAL PH MONITORING; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMAN; MECHANICAL STIMULATION; MECHANORECEPTOR; NONHUMAN; PANIC; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REFLUX ESOPHAGITIS; REVIEW; SOMATIZATION; STIMULUS RESPONSE; STOMACH PH; THORAX PAIN;

ANIMALS; BILE REFLUX; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMANS;

EID: 47249083793     PISSN: 17434378     EISSN: 17434386     Source Type: Journal    
DOI: 10.1038/ncpgasthep1160     Document Type: Review

References (78)

1. Vakil N et al. Global Consensus Group. (2006) The Montreal definition and classification of gastroesophageal reflux disease: A global evidence-based consensus. Am J Gastroenterol 101: 1900-1920
2. Fass R and Tougas G (2002) Functional heartburn: The stimulus, the pain and the brain. Gut 51, 885-892
3. Fass R et al. (2001) Nonerosive reflux disease. Current concepts and dilemmas. Am J Gastroenterol 96: 303-314
4. Kahrilas PJ (2003) Clinical vignette: Refractory heartburn. Gastroenterology 124: 1941-1945
5. Silny J (1991) Intraluminal multiple electrical impedance procedure for measurement of gastrointestinal motility. J Gastrointest Motil 3: 151-162
6. Bredenoord AJ et al. (2005) Reproducibility of multichannel intraluminal electrical impedance monitoring of gastroesophageal reflux. Am J Gastroenterol 100: 265-269
7. Bechi P et al. (1993) Long term ambulatory enterogastric reflux monitoring. Validation of a new fiberoptic technique. Dig Dis Sci 38: 1297-1306
8. Sifrim D et al. (2001) Composition of the postprandial refluxate in patients with gastroesophageal reflux disease. Am J Gastroenterol 96: 647-655
9. Sifrim D et al. (2001) Acid, nonacid, and gas reflux in patients with gastroesophageal reflux disease during ambulatory 24-hr pH-impedance recordings. Gastroenterology 120: 1588-1598
10. Smith JL et al. (1989) Sensitivity of the esophageal mucosa to pH in gastroesophageal reflux disease. Gastroenterology 96: 683-689
11. Carlsson R et al. (1998) The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease. Scand J Gastroenterol 33: 1023-1029
12. Holzer P (2003) Acid-sensitive ion channels in gastrointestinal function. Current Opin Pharmacol 3: 618-625
13. Tominaga M et al. (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21: 531-543
14. Caterina MJ and Julius D (2001) The vanilloid receptor: A molecular gateway to the pain pathway. Annu Rev Neurosci 24: 487-517
15. Hwang SW and Oh U (2002) Hot channels in airways: Pharmacology of the vanilloid receptor. Curr Opin Pharmacol 2: 235-242
16. Trevisani M et al. (2002) Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. Nat Neurosci 5: 546-551
17. Matthews PJ et al. (2004) Increased capsaicin receptor TRPV1 nerve fibres in the inflamed human oesophagus. Eur J Gastroenterol Hepatol 16: 897-902
18. Abdel-Salam Omar ME et al. (1999) Capsaicin sensitive afferent sensory nerves in modulating gastric mucosal defense against noxious agents. J Physiol (Paris) 93: 443-454
19. Kindt S et al. (2006) Influence of intra-esophageal capsaicin on heartburn induction and desensitization in man [abstract]. Gastroenterology 130 (Suppl 2): A392
20. Orlando RC (1998) Esophageal mucosal resistance. Aliment Pharmacol Ther 12: 191-197
21. Hopwood D et al. (1979) Electron microscopic changes in human esophageal epithelium in esophagitis. J Pathol 129: 161-167
22. Orlando RC (2006) Current understanding of the mechanisms of gastro-oesophageal reflux disease. Drugs 66 (Suppl 11): 1-5
23. Villanacci V et al. (2001) Dilated intercellular spaces as markers of reflux disease: Histology, semiquantitative scroe and morphometry upon light microscopy. Digestion 64: 1-8
24. Orlando RC et al. (1981) Pathophysiology of acute acid injury in rabbit esophageal epithelium. J Clin Invest 68: 286-293
25. Tobey NA et al. (1997) HCl-induced cell edema in primary cultured rabbit esophageal epithelium. Gastroenterology 112: 847-854
26. Farre R et al. (2007) Critical role of stress in increased esophageal mucosal permeability and dilated intercellular spaces. Gut 56: 1191-1197
27. Tobey NA et al. (2004) Dilated intercellular spaces and shunt permeability in nonerosive acid-damaged esophageal epithelium. Am J Gastroenterol 99: 13-22
28. Tobey NA et al. (1996) Dilated intercellular spaces: A morphological feature of acid reflux-damaged human esophageall epithelium. Gastroenterology 111: 1200-1205
29. Calabrese C et al. (2003) Dilated intercellular spaces as a marker of oesophageal damage: Comparative results in gastro-oesophageal reflux disease with or without bile reflux. Aliment Pharmacol Ther 18 525-532
30. Barlow WJ and Orlando RC (2005) The pathogenesis of heartburn in nonerosive reflux disease: A unifying hypothesis. Gastroenterology 128: 771-778
31. Calabrese C et al. (2002) Omeprazole and ultrastructural modications occurring in reflux esophagitis. Gastroenterology 122: 837
32. Marrero JM et al. (1994) Effect of famotidine on esophageal sensitivity in gastro-esophageal reflux disease. Gut 35: 447-450
33. Jung B et al. (2004) Lack of association between esophageal acid sensitivity detected by prolonged pH monitoring and Bernstein testing. Am J Gastroenterol 99: 410-415
34. Wiener GJ et al. (1988) The symptom index: A clinically important parameter of ambulatory 24-hour esophageal pH monitoring. Am J Gastroenterol 83: 358-361
35. Hewson EG et al. (1989) Acid perfusion test: Does it have a role in the assessment of non cardiac chest pain? Gut 30: 305-310
36. Koek GH et al. (2001) The role of acid and duodenal gastroesophageal reflux in symptomatic GERD. Am J Gastroenterol 96: 2033-2040
37. Weusten BL et al. (1995) Symptom perception in gastroesophageal reflux disease is dependent on spatiotemporal reflux characteristics. Gastroenterology 108: 1739-1744
38. Cicala M et al. (2003) Intraoesophageall distribution and perception of acid reflux in patients with non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther 18 605-613
39. Johnson LF and De Meester TR (1986) Development of the 24-hour intraesophageal pH monitoring composite scoring system. J Clin Gastroenterol 1: 747-767
40. Emerenziani S et al. (2005) Gastric fullness, physical activity, and proximal extent of gastroesophageal reflux. Am J Gastroenterol 100: 1251-1256
41. Schenk BE et al. (1997) Omeprazole as a diagnostic tool in gastroesophageal reflux disease. Am J Gastroenterol 92: 1997-2000
42. Smout AJ (1997) Endoscopy-negative acid reflux disease. Aliment Pharmacol Ther 11 (Suppl 2): 81-85
43. Martinez SD et al. (2003) Non erosive reflux disease (NERD) - acid reflux and symptom patterns. Aliment Pharmacol Ther 17: 537-545
44. Bredenoord AJ et al. (2006) Determinants of perception of heartburn and regurgitation. Gut 55:313-318
45. Vela MF et al. (2001) Simultaneous intraesophageal impedance and pH measurement of acid and nonacid gastroesophageal reflux: Effect of omeprazole. Gastroenterology 120: 1599-1606
46. Mainie I et al. (2006) Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: A multicentre study using combined ambulatory impedance-pH monitoring. Gut 55 1398-1402
47. Zerbib F et al. (2006) Esophageal pH impedance monitoring and symptom analysis in GERD: A study in patients off and on therapy. Am J Gastroenterol 101: 1956-1963
48. Stipa F et al. (1997) Assessment of non-acidic esophageal reflux: comparison between long-term reflux aspiration test and fiberoptic bilirubin monitoring. Dis Esophagus 10: 24-28
49. Vaezi MF and Richter JE (1996) Role of acid and duodenogastroesophageal reflux disease. Gastroenterology 111: 1992-1999
50. Tack J et al. (2004) Gastroesophageal reflux disease poorly responsive to single-dose proton pump inhibitors in patients without Barrett's esophagus: Acid reflux, bile reflux or both? Am J Gastroenterol 99: 981-988
51. Siddiqui A et al. (2005) Esophageal visceral sensitivity to bile salts in patients with functional heartburn and in healthy control subjects. Dig Dis Sci 50: 81-85
52. Tack J (2006) Review article: The role of bile and pepsin in the pathophysiology and treatment of gastroesophageal reflux disease. Aliment Pharmacol Ther 24(Suppl): 10-16
53. Gelbmann CM (1995) Mast cells and histamine contribute to bile acid stimulated secretion in the mouse colon. J Clin Invest 95: 2831-2839
54. Lanas AI et al. (1997) Adaptation of esophageal mucosa to acid- and pepsin-induced damage: Role of nitric oxide and epidermal growth factor. Dig Dis Sci 42: 1003-1012
55. Tobey NA et al. (2001) The role of pepsin in acid injury to esophageal epithelium. Am J Gastroenterol 96: 3062-3070
56. Farre R et al. (2007) Weakly acidic solutions containing pepsin and bile acids can significantly increase esophageal mucosa permeability [abstract]. Gastroenterology 132 (Suppl 2): A274
57. Hopwood D et al. (1981) Effects of bile acids and hydrogen ions on the fine structure of esophageal epithelium. Gut 22: 306-311
58. Fass R et al. (1998) Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 115: 1363-1373
59. Patel S and Rao S (1998) Biomechanical and sensory parameters of the human esophagus at four levels. Am J Physiol Gastrointest Liver Physiol 275: G187-G191
60. Mehta AJ et al. (1995) Sensitization to painful distension and abnormal sensory perception in the esophagus. Gastroenterology 108: 311-319
61. Peghini PL et al. (1996) Mucosal acid exposure sensitizes a subset of normal subjects to intraoesophageal balloon distension. Eur J Gastroenterol Hepatol 8: 979-983
62. DeVault KR (1997) Acid infusion does not affect intraesophageal balloon distension induced sensory and pain thresholds. Am J Gastroenterol 92: 947-949
63. Balaban DH et al. (1999) Sustained esophageal contraction: A marker of esophageal chest pain identified by intraluminal ultrasonography. Gastroenterology 116: 29-37
64. De Caestecker JS et al. (1992) Site and mechanism of pain perception with esophageal balloon distension and intravenous edrophonium in patients with esophageal chest pain. Gut 33: 580-586
65. Rao S et al. (1996) Unexplained chest pain: The hypersensitive, hyperreactive, and poorly compliant esophagus. Ann Intern Med 124: 950-958
66. Pehlivanov N et al. (2001) Relationship between esophageal muscle thickness and intraluminal pressure: An ultrasonographic study. Am J Physiol Gastrointest Liver Physiol 280: G1093-G1098
67. Pehlivanov N et al. (2001) Sustained esophageal contraction: A motor correlate of heartburn symptom. Am J Physiol Gastrointest Liver Physiol G743-G751
68. Sifrim D et al. (2003) Ambulatory continuous monitoring of esophageal shortening in man. Preliminary observations in patients with chest pain [abstract]. Gastroenterology 124 (Suppl 1): A121
69. Trimble K et al. (1995) Lowered esophageal sensory thresholds in patients with symptomatic but not excess gastro-oesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD. Gut 37 7-12
70. Mayer E and Gebhart GF (1994) Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 107: 271-293
71. Aziz Q (2001) Acid sensors in the gut: A taste of things to come. Eur J Gastroenterol Hepatol 13: 885-888
72. Sarkar S et al. (2000) Contribution of central sensitization to the development of non cardiac chest pain. Lancet 356: 1154-1159
73. Smout A et al. (1992) Cerebral potentials evoked by esophageal distension in patients with non-cardiac chest pain. Gut 33: 298-302
74. Aziz Q et al. (1997) Identification of human brain loci processing esophageal sensation using positron emission tomography. Gastroenterology 113: 50-59
75. Sarkar S (2001) Central neural mechanisms mediating human visceral hypersensitivity. Am J Physiol Gastrointest Liver Physiol 281 G1196-G1202
76. Richter J et al. (1986) Psychologic comparison of patients with nutcracker esophagus and irritable bowel syndrome. Dig Dis Sci 31: 131-138
77. Bradley LA et al. (1993) The relationship between stress and symptoms of gastroesophageal reflux: The influence of psychological factors. Am J Gastroenterol 88: 11-19
78. Naliboff BD et al. (2004) The effect of life stress on symptoms of heartburn. Psych Med 66: 426-434