Simultaneous determination of udenafil and its active metabolite, DA-8164, in human plasma and urine using ultra-performance liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study

Biomedical Chromatography

Volumn 22, Issue 9, 2008, Pages 939-946

  Bae, Soo Kyung ^a   Kang, Min Jeong ^b   Yeo, Chang Woo ^b   Kim, Min Jung ^b   Shon, Ji Hong ^a,b   Liu, Kwang Hyeon ^b,c   Shin, Jae Gook ^a,b  

^a Inje University College of Medicine   (South Korea)

^b Inje University College of Medicine   (South Korea)

^c Inje University   (South Korea)

Author keywords

DA 8164; Human plasma and urine; Udenafil; UPLC MS MS

Indexed keywords

LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PHARMACOKINETICS; PLASMA (HUMAN); PRECIPITATION (CHEMICAL);

ACTIVE METABOLITES; DA-8164; HUMAN PLASMAS; HUMAN URINE; INTERNAL STANDARDS; PHARMACOKINETIC STUDIES; SIMULTANEOUS DETERMINATIONS; UDENAFIL; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPLC-MS/MS;

ACETONITRILE;

ACETONITRILE; DA 8164; DRUG METABOLITE; FORMIC ACID; SILDENAFIL; UDENAFIL; UNCLASSIFIED DRUG;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; KOREA; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRECIPITATION; PROCESS DEVELOPMENT; QUANTITATIVE ANALYSIS; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS; VOLUNTEER;

EID: 53349096005     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1011     Document Type: Article

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