Simultaneous determination of a new phosphodiesterase-5 inhibitor DA-8159 and its active metabolite in human plasma by high performance liquid chromatography with tandem mass spectrometry

Chromatographia

Volumn 57, Issue 7-8, 2003, Pages 447-450

  Kim, J ^a   Kim, S J ^b   Ji, H Y ^b   Jin, J K ^b   Lee, S S ^b   Kim, D S ^c   Yoo, M ^c   Kim, W B ^c   Lee, H S ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Wonkwang University   (South Korea)

^c Dong A Pharmaceutical Company   (South Korea)

Author keywords

Column liquid chromatography; DA 8159 and metabolite; Plasma; Tandem mass spectrometry

Indexed keywords

5 (2 PROPOXY 5 AMINOSULFONYLPHENYL) 1 METHYL 3 PROPYL 1,6 DIHYDRO 7H PYRAZOLO[4,3 D]PYRIMIDIN 7 ONE; 5 [2 PROPYLOXY 5 (1 METHYL 2 PYRROLIDINYLETHYLAMIDOSULFONYL)PHENYL] 1 METHYL 3 PROPYL 1,6 DIHYDRO 7H PYRAZOLO[4,3 D]PYRIMIDIN 7 ONE; DA 8164; PHOSPHODIESTERASE INHIBITOR; SILDENAFIL; UDENAFIL; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BLOOD ANALYSIS; CHEMICAL REACTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; HUMAN; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STANDARD; TANDEM MASS SPECTROMETRY;

EID: 0037394652     PISSN: 00095893     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02492539     Document Type: Article

References (3)

1. Oh, T.Y.; Kang, K.K.; Ahn, B.O.; Yoo, M.; Kim, W.B. Arch. Pharm. Res. 2000, 23, 471-476.
2. Choi, S.J.; Ji, H.Y.; Lee, H.-Y.; Kim, D.S.; Kim, W.B.; Lee, H.S. Biomed. Chromatogr. 2002, 16, 395-399.
3. Shim, H.J.; Lee, E.J.; Jung, Y.H.; Kim, S.H.; Kim, S.H.; Yoo, M.; Kwon, J.W.; Kim, W.B.; Lee, M.G. J. Pharm. Biomed. Anal. 2002, 30, 527-533.