PMMA is superior to hydroxyapatite for colony reduction in induced osteomyelitis

Clinical Orthopaedics and Related Research

Volumn 462, Issue , 2007, Pages 190-194

  Zelken, Jonathan ^a   Wanich, Tony ^a   Gardner, Michael ^a   Griffith, Matthew ^a   Bostrom, Mathias ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYAPATITE; POLY(METHYL METHACRYLATE); VANCOMYCIN; ANTIINFECTIVE AGENT; BIOMATERIAL; BONE CEMENT; DRUG CARRIER; POLYMETHACRYLIC ACID; POLYMETHACRYLIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIUM COLONY; BONE; COLONY FORMING UNIT; CONTROL GROUP; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; HYPOTHESIS; LOW DRUG DOSE; NONHUMAN; OSTEOMYELITIS; PRIORITY JOURNAL; RAT; TREATMENT DURATION; ANIMAL; BACTERIAL COUNT; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; INJURY; MICROBIAL VIABILITY; MICROBIOLOGY; RADIOGRAPHY; SPRAGUE DAWLEY RAT; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; TIBIA; TREATMENT OUTCOME;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOCOMPATIBLE MATERIALS; BONE CEMENTS; COLONY COUNT, MICROBIAL; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DURAPATITE; FEMALE; MICROBIAL VIABILITY; OSTEOMYELITIS; POLYMETHACRYLIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TIBIA; TREATMENT OUTCOME; VANCOMYCIN;

EID: 34548403405     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/BLO.0b013e3180ca9521     Document Type: Article

References (18)

1. An YH, Friedman RJ. Animal models of orthopedic implant infection. J Invest Surg. 1998;11:139-146.
2. Chohfi M, Langlais F, Fourastier J, Minet J, Thomazeau H, Cormier M. Pharmacokinetics, uses, and limitations of vancomycin-loaded bone cement. Int Orthop. 1998;22:171-177.
3. Dickson KF, Friedman J, Buchholz JG, Flandry FD. The use of BoneSource hydroxyapatite cement for traumatic metaphyseal bone void filling. J Trauma. 2002;53:1103-1108.
4. Eron LJ. Prevention of infection following orthopedic surgery. Antibiot Chemother. 1985;33:140-164.
5. Ganguli A, Steward C, Butler SL, Philips GJ, Meikle ST, Lloyd AW, Grant MH. Bacterial adhesion to bisphosphonate coated hydroxyapatite. J Mater Sci Mater Med. 2005;16:283-287.
6. Hanssen AD, Spangehl MJ. Practical applications of antibioticloaded bone cement for treatment of infected joint replacements. Clin Orthop Relat Res. 2004;427:79-85.
7. Joosten U, Joist A, Gosheger G, Liljenqvist U, Brandt B, von Eiff C. Effectiveness of hydroxyapatite-vancomycin bone cement in the treatment of Staphylococcus aureus induced chronic osteomyelitis. Biomaterials. 2005;26:5251-5258.
8. Korkusuz F, Uchida A, Shinto Y, Araki N, Inoue K, Ono K. Experimental implant-related osteomyelitis treated by antibiotic-calcium hydroxyapatite ceramic composites. J Bone Joint Surg Br. 1993;75:111-114.
9. Lucke M, Schmidmaier G, Sadoni S, Wildemann B, Schiller R, Steinberger A, Haas NP, Raschke M. A new model of implantrelated osteomyelitis in rats. J Biomed Mater Res B Appl Biomater. 2003;67:593-602.
10. McLaren AC. Alternative materials to acrylic bone cement for delivery of depot antibiotics in orthopaedic infections. Clin Orthop Relat Res. 2004;427:101-106.
11. Miclau T, Dahners LE, Lindsey RW. In vitro pharmacokinetics of antibiotic release from locally implantable materials. J Orthop Res. 1993;11:627-632.
12. Penner MJ, Duncan CP, Masri BA. The in vitro elution characteristics of antibiotic-loaded CMW and Palacos® bone cements. J Arthroplasty. 1999;14:209-214.
13. Penner MJ, Masri BA, Duncan CP. Elution characteristics of vancomycin and tobramycin combined in acrylic bone-cement. J Arthroplasty. 1996;11:939-944.
14. Shirtliff ME, Calhoun JH, Mader JT. Experimental osteomyelitis treatment with antibiotic-impregnated hydroxyapatite. Clin Orthop Relat Res. 2002;401:239-247.
15. Solberg BD, Gutow AP, Baumgaertner MR. Efficacy of gentamicin-impregnated resorbable hydroxyapatite cement in treating osteomyelitis in a rat model. J Orthop Trauma. 1999;13:102-106.
16. Southorn PA, Plevak DJ, Wright AJ, Wilson WR. Adverse effects of vancomycin administered in the perioperative period. Mayo Clin Proc. 1986;61:721-724.
17. Wahlig H, Dingeldein E. Antibiotics and bone cements: experimental and clinical long-term observations. Acta Orthop Scand. 1980;51:49-56.
18. Wood MJ. The comparative efficacy and safety of teicoplanin and vancomycin. J Antimicrob Chemother. 1996;37:209-222.