Induction of apoptosis by phenethyl isothiocyanate in cells overexpressing Bcl-XL

Cancer Letters

Volumn 271, Issue 2, 2008, Pages 215-221

  Cuddihy, Sarah L ^a   Brown, Kristin K ^a   Thomson, Susan J ^a   Hampton, Mark B ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Apoptosis; Bcl 2; Bcl XL; Caspases; Phenethyl isothiocyanate

Indexed keywords

CASPASE; CYSTEINE; PHENFORMIN; PROTEIN BCL 2; PROTEIN BCL XL;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LD 50; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTICARCINOGENIC AGENTS; APOPTOSIS; BCL-X PROTEIN; HUMANS; ISOTHIOCYANATES; JURKAT CELLS; MUTATION;

EID: 53249149116     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.06.002     Document Type: Article

References (24)

1. Amundson S.A., Myers T.G., Scudiero D., Kitada S., Reed J.C., and Fornace Jr. A.J. An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res. 60 (2000) 6101-6110
2. Addeo R., Caraglia M., Baldi A., D'Angelo V., Casale F., Crisci S., et al. Prognostic role of bcl-xl and p53 in childhood acute lymphoblastic leukemia (all). Cancer Biol. Ther. 4 (2005) 32-38
3. Oltersdorf T., Elmore S.W., Shoemaker A.R., Armstrong R.C., Augeri D.J., Belli B.A., et al. An inhibitor of bcl-2 family proteins induces regression of solid tumours. Nature 435 (2005) 677-681
4. Shoemaker A.R., Oleksijew A., Bauch J., Belli B.A., Borre T., Bruncko M., et al. A small-molecule inhibitor of bcl-xl potentiates the activity of cytotoxic drugs in vitro and in vivo. Cancer Res. 66 (2006) 8731-8739
5. Fowke J.H., Chung F.-L., Jin F., Qi D., Cai Q., Conaway C., et al. Urinary isothiocyanate levels, brassica, and human breast cancer. Cancer Res. 63 (2003) 3980-3986
6. Munday R., Mhawech-Fauceglia P., Munday C.M., Paonessa J.D., Tang L., Munday J.S., et al. Inhibition of urinary bladder carcinogenesis by broccoli sprouts. Cancer Res. 68 (2008) 1593-1600
7. Chen Y.-R., Wang W., Kong A.-N.T., and Tan T.-H. Molecular mechanisms of c-jun n-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates. J. Biol. Chem. 273 (1998) 1769-1775
8. Yu R., Mandlekar S., Harvey K.J., Ucker D.S., and Kong A.N. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Res. 58 (1998) 402-408
9. Thomson S.J., Brown K.K., Pullar J.M., and Hampton M.B. Phenethyl isothiocyanate triggers apoptosis in Jurkat cells made resistant by the overexpression of bcl-2. Cancer Res. 66 (2006) 6772-6777
10. Pullar J.M., Thomson S.J., King M.J., Turnbull C.I., Midwinter R.G., and Hampton M.B. The chemopreventive agent phenethyl isothiocyanate sensitizes cells to fas-mediated apoptosis. Carcinogenesis 25 (2004) 765-772
11. Gemeiner P., Augustin J., and Drobnica L. Reactions of cellulose isothiocyanates with thiol and amino compounds. Carbohydr. Res. 53 (1977) 217-222
12. Zhang Y., Kolm R.H., Mannervik B., and Talalay P. Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases. Biochem. Biophys. Res. Co. 206 (1995) 748-755
13. Thornalley P.J. Isothiocyanates: mechanism of cancer chemopreventive action. Anti-Cancer Drug 13 (2002) 331-338
14. Martin S.J., and Green D.R. Apoptosis and cancer: the failure of controls on cell death and cell survival. Crit. Rev. Oncol. Hemat. 18 (1995) 137-153
15. Azad N., Vallyathan V., Wang L., Tantishaiyakul V., Stehlik C., Leonard S.S., et al. S-nitrosylation of bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptotic mechanism that suppresses apoptosis. J. Biol. Chem. 281 (2006) 34124-34134
16. Wu S.-J., Ng L.T., and Lin C.-C. Effects of antioxidants and caspase-3 inhibitor on the phenethyl isothiocyanate-induced apoptotic signaling pathways in human plc/prf/5 cells. Eur. J. Pharmacol. 518 (2005) 96-106
17. Xiao D., Vogel V., and Singh S.V. Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by bax and bak. Mol. Cancer Ther. 5 (2006) 2931-2945
18. Makmura L., Hamann M., Areopagita A., Furuta S., Munoz A., and Momand J. Development of a sensitive assay to detect reversibly oxidized protein cysteine sulfhydryl groups. Antioxid. Redox Signal. 3 (2001) 1105-1118
19. Xiao D., Lew K.L., Zeng Y., Xiao H., Marynowski S.W., Dhir R., et al. Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential. Carcinogenesis 27 (2006) 2223-2234
20. Pellecchia M., and Reed J.C. Inhibition of anti-apoptotic bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy. Curr. Pharm. Design 10 (2004) 1387-1398
21. Xiao D., Zeng Y., Choi S., Lew K.L., Nelson J.B., and Singh S.V. Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by bak and bax. Clin. Cancer Res. 11 (2005) 2670-2679
22. Miyoshi N., Uchida K., Osawa T., and Nakamura Y. A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in bcl-2 phosphorylation. Cancer Res. 64 (2004) 2134-2142
23. Tang L., and Zhang Y. Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells. Mol. Cancer Ther. 4 (2005) 1250-1259
24. Basu A., and Haldar S. Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis. FEBS Lett. 538 (2003) 41-47