Design, synthesis and evaluation of new 6-substituted-5-benzyloxy-4- oxo-4H-pyran-2-carboxamides as potential Src inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 23, Issue 5, 2008, Pages 629-640

  Farard, Julien ^a   Lanceart, Gaëtan ^a   Logé, Cedric ^a   Nourrisson, Marie Renée ^a   Cruzalegui, Francisco ^b   Pfeiffer, Bruno ^b   Duflos, Muriel ^a  

^a UNIVERSITÉ DE NANTES   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Amide bond formation; Cancer; Drug design; Pyran 4 one; Src

Indexed keywords

3 BENZYLOXY 2 HYDROXYMETHYL 6 [(TETRAHYDRO 2H PYRAN 2 YLOXY)METHYL] 4H PYRAN 4 ONE; 3 BENZYLOXY 2,6 BIS(HYDROXYMETHYL) 4H PYRAN 4 ONE; 3 BENZYLOXY 6 HYDROXYMETHYL 2 (1 HYDROXY 2 METHYLPROPYL) 4H PYRAN 4 ONE; 3 BENZYLOXY 6 HYDROXYMETHYL 2 ISOBUTYL 4H PYRAN 4 ONE; 3 BENZYLOXY 6 HYDROXYMETHYL 2 METHYL 4H PYRAN 4 ONE; 3 HYDROXY 2 HYDROXYMETHYL 6 [(TETRAHYDRO 2H PYRAN 2 YLOXY)METHYL] 4H PYRAN 4 ONE; 3 HYDROXY 2,6 BIS(HYDROXYMETHYL) 4H PYRAN 4 ONE; 3 HYDROXY 6 HYDROXYMETHYL 2 (1 HYDROXY 2 METHYLPROPYL) 4H PYRAN 4 ONE; 5 BENZYLOXY 4 OXO 4H PYRAN 2 CARBOXAMIDE DERIVATIVE; 5 BENZYLOXY 4 OXO 4H PYRAN 2 CARBOXYLIC ACID; 5 BENZYLOXY 4 OXO N PHENYL 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY 6 ISOBUTYL 4 OXO 4H PYRAN 2 CARBOXYLIC ACID; 5 BENZYLOXY 6 ISOBUTYL 4 OXO N PHENYL 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY 6 ISOBUTYL N (2 CHLORO 6 METHYLPHENYL) 4 OXO 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY 6 ISOBUTYL N (2 CHLOROPHENYL) 4 OXO 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY 6 ISOBUTYL N (2,6 DICHLOROPHENYL) 4 OXO 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY 6 ISOBUTYL N (2,6 DIMETHYLPHENYL) 4 OXO 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY 6 METHYL 4 OXO N PHENYL 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY 6 METHYL N (2 CHLORO 6 METHYLPHENYL) 4 OXO 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY 6 METHYL N (2 CHLOROPHENYL) 4 OXO 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY 6 METHYL N (2,6 DICHLOROPHENYL) 4 OXO 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY 6 METHYL N (2,6 DIMETHYLPHENYL) 4 OXO 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY N (2 CHLORO 6 METHYLPHENYL) 4 OXO 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY N (2 CHLOROPHENYL) 4 OXO 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY N (2,6 DICHLOROPHENYL) 4 OXO 4H PYRAN 2 CARBOXAMIDE; 5 BENZYLOXY N (2,6 DIMETHYLPHENYL) 4 OXO 4H PYRAN 2 CARBOXAMIDE; 5 HYDROXY 2 [(TETRAHYDRO 2H PYRAN 2 YLOXY)METHYL] 4H PYRAN 4 ONE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; PRIORITY JOURNAL;

AMIDES; ANTINEOPLASTIC AGENTS; CATALYTIC DOMAIN; DRUG DISCOVERY; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 53249093798     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360802205299     Document Type: Article

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