Effects of a low oral dose of diethylstilbestrol (DES) on reproductive tract development in F1 female CD-1 mice

Reproductive Toxicology

Volumn 26, Issue 2, 2008, Pages 146-150

  Maranghi, Francesca ^a   Tassinari, Roberta ^a   Moracci, Gabriele ^a   Macrì, Caterina ^a   Mantovani, Alberto ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Early exposure; Endocrine disrupting chemicals; Female reproductive system; Long term effects; Model compound

Indexed keywords

DIETHYLSTILBESTROL; ENDOCRINE DISRUPTOR; ESTROGEN RECEPTOR; OLIVE OIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENDOMETRIUM ATROPHY; FEMALE; FEMALE GENITAL SYSTEM; GESTATION PERIOD; HISTOPATHOLOGY; LACTATION; MOUSE; NONHUMAN; OVARY FOLLICLE; PREGNANCY; PUBERTY; REPRODUCTIVE TOXICITY; SEXUAL DEVELOPMENT; SEXUAL MATURATION; TOXICITY TESTING; UTERUS WEIGHT; WEIGHT REDUCTION;

ADMINISTRATION, ORAL; ANIMALS; DIETHYLSTILBESTROL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGENS, NON-STEROIDAL; FEMALE; GENITALIA, FEMALE; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED STRAINS; OVARY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; UTERUS; VAGINA;

MUS;

EID: 53249091931     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2008.07.002     Document Type: Article

References (33)

1. Folmar L.C., Hemmer M.J., Denslow N.D., Kroll K., Chen J., Cheek A., et al. A comparison of the estrogenic potencies of estradiol, ethynylestradiol, diethylstilbestrol, nonylphenol and methoxychlor in vivo and in vitro. Aquat Toxicol 60 (2002) 101-110
2. Delbès G., Duquenne C., Szenker J., Taccoen J., Habert R., and Levacher C. Developmental changes in testicular sensitivity to estrogens throughout fetal and neonatal life. Toxicol Sci 99 (2007) 234-243
3. Haney A.F., Newbold R.R., and McLachlan J.A. Prenatal diethylstilbestrol exposure in the mouse: effects on ovarian histology and steroidogenesis in vitro. Biol Reprod 30 (1984) 471-478
4. Couse J.F., and Korach K.S. Estrogen receptor-alpha mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract. Toxicology 205 (2004) 55-63
5. Schrager S., and Potter B.E. Diethylstilbestrol exposure. Am Fam Physician 15 69 (2004) 2395-2400
6. Mericskay M., Carta L., and Sassoon D. Diethylstilbestrol exposure in utero: a paradigm for mechanisms leading to adult disease. Birth Defects Res A Clin Mol Teratol 73 (2005) 133-135
7. Hammes B., and Laitman C.J. Diethylstilbestrol (DES) update: recommendations for the identification and management of DES-exposed individuals. J Midwifery Women Health 48 (2003) 19-29
8. Herbst A.L., Ulfelder H., and Poskanzer D.C. Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 284 15 (1971) 878-881
9. Opinion of the Scientific Panel on contaminants in the food chain (CONTAM) related to hormone residues in bovine meat and meat products). EFSA Journal Question number: EFSA-Q-2005-048, 2007. http://www.efsa.europa.eu/EFSA/efsa_locale-1178620753812_1178622336805.htm.
10. Iguchi T., Takasugi N., Bern H.A., and Mills K.T. Frequent occurrence of polyovular follicles in ovaries of mice exposed neonatally to diethylstilbestrol. Teratology 34 1 (1986) 29-35
11. Newbold R.R., Padilla-Banks E., and Jefferson W.N. Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinology 147 (2006) S11-S17
12. Yin Y., and Ma L. Development of the mammalian female reproductive tract. J Biochem (Tokyo) 137 (2005) 677-683
13. Newbold R.R., Hanson R.B., Jefferson W.N., Bullock B.C., Haseman J., and McLachlan J.A. Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis 21 (2000) 1355-1363
14. Kubo K., Arai O., Omura M., Watanabe R., Ogata R., and Aou S. Low dose effects of bisphenol A on sexual differentiation the brain and behavior in rats. Neurosci Res 45 (2003) 345-356
15. Maranghi F., Rescia M., Macrì C., Di Consiglio E., De Angelis G., Testai E., et al. Lindane may modulate the female reproductive development through the interaction with ER-beta: an in vivo-in vitro approach. Chem Biol Interact 169 (2007) 1-14
16. Fortune J.E. The early stages of follicular development: activation of primordial follicles and growth of preantral follicles. Anim Reprod Sci 78 (2003) 135-163
17. Barnett K.R., Schilling C., Greenfeld C.R., Tomic D., and Flaws J.A. Ovarian follicle development and transgenic mouse models. Hum Reprod Update 12 (2006) 537-555
18. Nikaido Y., Yoshizawa K., Danbara N., Tsujita-Kyutoku M., Yuri T., Uehara N., et al. Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring. Reprod Toxicol 18 (2004) 803-811
19. Schonfelder G., Friedrich K., Paul M., and Chahoud I. Developmental effects of prenatal exposure to bisphenol a on the uterus of rat offspring. Neoplasia 6 (2004) 584-594
20. Yoshida A., Newbold R.R., and Dixon D. Effects of neonatal diethylstilbestrol (DES) exposure on morphology and growth patterns of endometrial epithelial cells in CD-1 mice. Toxicol Pathol 27 (1999) 325-333
21. Fong C.J., Burgoon L.D., Williams K.J., Forgacs A.L., and Zacharewski T.R. Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice. BMC Genom 8 June 7 (2007) 151
22. Lewis J.S., and Jordan V.C. Selective estrogen receptor modulators (SERMs): mechanisms of anticarcinogenesis and drug resistance. Mutat Res 591 (2005) 247-263
23. Karlsson S. Histopathology and histomorphometry of the urogenital tract in 15-month old male and female rats treated neonatally with SERMs and estrogens. Exp Toxicol Pathol 58 (2006) 1-12
24. Pocar P., Brevini T.A., Fischer B., and Gandolfi F. The impact of endocrine disruptors on oocyte competence. Reproduction 125 (2003) 313-325
25. Suzuki A., Sugihara A., Uchida K., Sato T., Ohta Y., Katsu Y., et al. Developmental effects of perinatal exposure to bisphenol-A and diethylstilbestrol on reproductive organs in female mice. Reprod Toxicol 16 (2002) 107-116
26. Fenton S.E. Endocrine-disrupting compounds and mammary gland development: early exposure and later life consequences. Endocrinology 147 6 Suppl (2006) S18-S24
27. Murray T.J., Maffini M.V., Ucci A.A., Sonnenschein C., and Soto A.M. Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure. Reprod Toxicol 23 (2007) 383-390
28. Vandenberg L.N., Maffini M.V., Wadia P.R., Sonnenschein C., Rubin B.S., and Soto A.M. Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland. Endocrinology 148 (2007) 116-127
29. Marselos M., and Tomatis L. Diethylstilboestrol: I, pharmacology, toxicology and carcinogenicity in humans. Eur J Cancer 28 (1992) 1182-1189
30. Marselos M., and Tomatis L. Diethylstilboestrol: II, pharmacology, toxicology and carcinogenicity in experimental animals. Eur J Cancer 29 (1992) 149-155
31. Miller K.P., Borgeest C., Greenfeld C., Tomic D., and Flaws J.A. In utero effects of chemicals on reproductive tissues in females. Toxicol Appl Pharmacol 198 (2004) 111-131
32. Kanno J., Onyon L., Haseman J., Fenner-Crisp P., Ashby J., and Owens W. Organisation for Economic Co-operation and Development. The OECD program to validate the rat uterotrophic bioassay to screen compounds for in vivo estrogenic responses: phase 1. Environ Health Perspect 109 (2001) 785-794
33. Moggs J.G., Tinwell H., Spurway T., Chang H.S., Pate I., Lim F.L., et al. Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth. Environ Health Perspect 112 (2004) 1589-1606