Neuropathological assessment of artemether-treated severe malaria

Lancet

Volumn 362, Issue 9380, 2003, Pages 295-296

  Hien, T T ^a   Turner, G D H ^b   Mai, N T H ^a   Phu, N H ^a   Bethell, D ^b,c   Blakemore, W F ^d   Cavanagh, J B ^e   Dayan, A ^f   Medana, I ^b   Weller, R O ^h   Day, N P J ^b,c   White, Nicholas J ^b,g  

^a UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c OXFORD UNIVERSITY CLINICAL RESEARCH UNIT   (Viet Nam)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^g MAHIDOL UNIVERSITY   (Thailand)

^h Mahidol University ^*

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER; QUININE;

ADULT; ARTICLE; AXONAL INJURY; BRAIN EDEMA; BRAIN NECROSIS; BRAIN STEM INJURY; CHROMATIN; CLINICAL ARTICLE; CONTROLLED STUDY; DEATH; DISEASE SEVERITY; DRUG MEGADOSE; FEMALE; HUMAN; HUMAN TISSUE; MALARIA FALCIPARUM; MALE; MORTALITY; NERVE CELL LESION; NERVE CELL NECROSIS; NERVE FIBER DEGENERATION; NEUROLOGIC EXAMINATION; NEUROPATHOLOGY; NEUROTOXICITY; PRIORITY JOURNAL; WHITE MATTER;

EID: 10744219769     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)13974-8     Document Type: Article

References (5)

1. A meta-analysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria. Trans R Soc Trop Med Hyg. 95:2001;637-650.
2. Hien T.T., Day N.P.J., Phu N.H., et al. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. N Engl J Med. 335:1996;76-83.
3. Petras J.M., Kyle D.E., Gettatacamin M., et al. Arteether: risks of two week administration in Macaca mulatta. Am J Trop Med Hyg. 56:1997;390-396.
4. Medana I.M., Mai N.T.H., Day N.P.J., et al. Cellular stress and injury responses in the brains of adult Vietnamese patients with fatal Plasmodium falciparum malaria. Neuropathol Appl Neurobiol. 27:2001;421-433.
5. Nontprasert A., Pukrittayakamee S., Nosten-Bertrand M., Vanijanonta S., White N.J. Studies of the neurotoxicity of oral artemisinin derivatives in mice. Am J Trop Med Hyg. 62:2000;409-412.