Binding of C/EBPβ to the C-reactive protein (CRP) promoter in Hep3B cells is associated with transcription of CRP mRNA

Journal of Immunology

Volumn 181, Issue 4, 2008, Pages 2420-2427

  Young, Duprane Pedaci ^a,c   Kushner, Irving ^b   Samols, David ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; PROTEIN P50; STAT3 PROTEIN; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR REL; AUTACOID;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; KINETICS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; RNA TRANSCRIPTION; BIOSYNTHESIS; CHROMATIN; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; IMMUNOPRECIPITATION; LIVER CELL; METABOLISM; TUMOR CELL LINE;

C-REACTIVE PROTEIN; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL LINE, TUMOR; CHROMATIN; HEPATOCYTES; HUMANS; IMMUNOPRECIPITATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 53149109760     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.4.2420     Document Type: Article

References (36)

1. Volanakis, J. E. 2001. Human C-reactive protein: expression, structure, and function. Mol. Immunol. 38: 189-197.
2. Black, S., I. Kushner, and D. Samols. 2004. C-reactive Protein. J. Biol. Chem. 279: 48487-48490.
3. Ganapathi, M., D. Rzewnicki, D. Samols, S. Jiang, and I. Kushner. 1991. Effect of combinations of cytokines and hormones on synthesis of serum amyloid A and C-reactive protein in Hep 3B cells. J. Immunol. 147: 1261-1265.
4. Ganter, U., R. Arcone, C. Toniatti, G. Morrone, and G. Ciliberto. 1989. Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J. 8: 3773-3779.
5. Jiang, S. L., G. Lozanski, D. Samols, and I. Kushner. 1995. Induction of human serum amyloid A in Hep 3B cells by IL-6 and IL-1β involves both transcriptional and post-transcriptional mechanisms. J. Immunol. 154: 825-831.
6. Li, S. P., T. Y. Liu, and N. D. Goldman. 1990. cis-Acting elements responsible for interleukin-6 inducible C-reactive protein gene expression. J. Biol. Chem. 265: 4136-4142.
7. Zhang, D., S. Jiang, D. Rzewnicki, D. Samols, and I. Kushner. 1995. The effect of interleukin-1 on C-reactive protein expression in Hep3B cells is exerted at the transcriptional level. Biochem. J. 310(Pt. 1): 143-148.
8. Majello, B., R. Arcone, C. Toniatti, and G. Ciliberto. 1990. Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter. EMBO J. 9: 457-465.
9. Cha-Molstad, H., A. Agrawal, D. Zhang, D. Samols, and I. Kushner. 2000. The Rel family member P50 mediates cytokine-induced C-reactive protein expression by a novel mechanism. J. Immunol. 165: 4592-4597.
10. Li, S. P., and N. D. Goldman. 1996. Regulation of human C-reactive protein gene expression by two synergistic IL-6 responsive elements. Biochemistry 35: 9060-9068.
11. Agrawal, A., D. Samols, and I. Kushner. 2003. Transcription factor c-Rel enhances C-reactive protein expression by facilitating the binding of C/EBPβ to the promoter. Mol. Immunol. 40: 373-380.
12. Cha-Molstad, H., D. P. Young, I. Kushner, and D. Samols. 2007. The interaction of C-Rel with C/EBPβ enhances C/EBPβ binding to the C-reactive protein gene promoter. Mol. Immunol. 44: 2933-2942.
13. Agrawal, A., H. Cha-Molstad, D. Samols, and I. Kushner. 2001. Transactivation of C-reactive protein by IL-6 requires synergistic interaction of CCAAT/enhancer binding protein β (C/EBPβ) and Rel p50. J. Immunol. 166: 2378-2384.
14. Agrawal, A., H. Cha-Molstad, D. Samols, and I. Kushner. 2003. Overexpressed nuclear factor-κB can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBPβ and signal transducer and activator of transcription-3. Immunology 108: 539-547.
15. Zhang, D., M. Sun, D. Samols, and I. Kushner. 1996. STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6. J. Biol. Chem. 271: 9503-9509.
16. Kushner, I., S. L. Jiang, D. Zhang, G. Lozanski, and D. Samols. 1995. Do posttranscriptional mechanisms participate in induction of C-reactive protein and serum amyloid A by IL-6 and IL-1? Ann. NY Acad. Sci. 762: 102-107.
17. Guenther, M. G., S. S. Levine, L. A. Boyer, R. Jaenisch, and R. A. Young. 2007. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 130: 77-88.
18. Reid, G., M. R. Hubner, R. Metivier, H. Brand, S. Denger, D. Manu, J. Beaudouin, J. Ellenberg, and F. Gannon. 2003. Cyclic, proteasome-mediated turnover of unliganded and liganded ERα on responsive promoters is an integral feature of estrogen signaling. Mol. Cell. 11: 695-707.
19. Nagaich, A. K., D. A. Walker, R. Wolford, and G. L. Hager. 2004. Rapid periodic binding and displacement of the glucocorticoid receptor during chromatin remodeling. Mol. Cell. 14: 163-174.
20. Hager, G. L., C. Elbi, T. A. Johnson, T. Voss, A. K. Nagaich, R. L. Schiltz, Y. Qiu, and S. John. 2006. Chromatin dynamics and the evolution of alternate promoter states. Chromosome Res. 14: 107-116.
21. Poli, V. 1998. The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J. Biol. Chem. 273: 29279-29282.
22. Alam, T., M. R. An, and J. Papaconstantinou. 1992. Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response. J. Biol. Chem. 267: 5021-5024.
23. Luedde, T., M. Duderstadt, K. L. Streetz, F. Tacke, S. Kubicka, M. P. Manns, and C. Trautwein. 2004. C/EBPβ isoforms LIP and LAP modulate progression of the cell cycle in the regenerating mouse liver. Hepatology 40: 356-365.
24. Yu, S. H., W. C. Chiang, H. M. Shih, and K. J. Wu. 2004. Stimulation of c-Rel transcriptional activity by PKA catalytic subunit β. J. Mol. Med. 82: 621-628.
25. Sanchez-Valdepenas, C., A. G. Martin, P. Ramakrishnan, D. Wallach, and M. Fresno. 2006. NF-κB-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activity. J. Immunol. 176: 4666-4674.
26. Sanchez-Valdepenas, C., C. Punzon, B. San-Antonio, A. G. Martin, and M. Fresno. 2007. Differential regulation of p65 and c-Rel NF-κB transactivating activity by Cot, protein kinase C - and NIK protein kinases in CD3/CD28 activated T cells. Cell Signal 19: 528-537.
27. Choi, Y. S., J. Hur, and S. Jeong. 2007. Beta-catenin binds to the downstream region and regulates the expression C-reactive protein gene. Nucleic Acids Res. 35: 5511-5519.
28. Ridker, P., N. Rifai, W. Koenig, and R. S. Blumenthal. 2006. C-reactive protein and cardiovascular risk in the Framingham Study. Arch. Intern. Med. 166: 1327-1328.
29. Jialal, I., S. Devaraj, and U. Singh. 2006. C-reactive protein and the vascular endothelium: implications for plaque instability. J. Am. Coll. Cardiol. 47: 1379-1381.
30. Pepys, M. B., G. M. Hirschfield, G. A. Tennent, J. R. Gallimore, M. C. Kahan, V. Bellotti, P. N. Hawkins, R. M. Myers, M. D. Smith, A. Polara, et al. 2006. Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 440: 1217-1221.
31. Chang, M. K., C. J. Binder, M. Torzewski, and J. L. Witztum. 2002. C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids. Proc. Natl. Acad. Sci. USA 99: 13043-13048.
32. Paul, A., K. W. Ko, L. Li, V. Yechoor, M. A. McCrory, A. J. Szalai, and L. Chan. 2004. C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation 109: 647-655.
33. Nissen, S. E., E. M. Tuzcu, P. Schoenhagen, T. Crowe, W. J. Sasiela, J. Tsai, J. Orazem, R. D. Magorien, C. O'Shaughnessy, and P. Ganz. 2005. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N. Engl. J. Med. 352: 29-38.
34. Mold, C., and H. Gewurz. 1981. Inhibitory effect of C-reactive protein on alternative C pathway activation by liposomes and Streptococcus pneumoniae. J. Immunol. 127: 2089-2092.
35. Szalai, A. J., D. E. Briles, and J. E. Volanakis. 1995. Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in transgenic mice. J. Immunol. 155: 2557-2563.
36. Yother, J., J. E. Volanakis, and D. E. Briles. 1982. Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in mice. J. Immunol. 128: 2374-2376.