A novel LQT-3 mutation disrupts an inactivation gate complex with distinct rate-dependent phenotypic consequences

Channels

Volumn 1, Issue 4, 2007, Pages 273-280

  Bankston, John R ^a   Sampson, Kevin J ^a   Kateriya, Suneel ^a   Glaaser, Ian W ^a   Malito, David L ^a   Chung, Wendy K ^b   Kass, Robert S ^a  

^a NewYork Presbyterian Hospital   (United States)

^b College of Physicians and Surgeons of Columbia University ^*  (United States)

Author keywords

Arrhythmia; Channelopathy; Heritable; Inactivation; Sodium

Indexed keywords

MUSCLE PROTEIN; SCN5A PROTEIN, HUMAN; SODIUM; SODIUM CHANNEL;

ACTION POTENTIAL; AMINO ACID SUBSTITUTION; ARTICLE; BIOLOGICAL MODEL; CASE REPORT; CHANNEL GATING; CHEMISTRY; CHILD; ELECTROCARDIOGRAPHY; GENETIC PREDISPOSITION; GENETICS; HEART ARRHYTHMIA; HEART MUSCLE CONDUCTION SYSTEM; HEART RATE; HUMAN; KINETICS; LONG QT SYNDROME; MALE; METABOLISM; MUTATION; PATHOPHYSIOLOGY; PEDIGREE; PHENOTYPE; PROBABILITY; PROTEIN CONFORMATION;

ACTION POTENTIALS; AMINO ACID SUBSTITUTION; ARRHYTHMIAS, CARDIAC; CHILD; ELECTROCARDIOGRAPHY; GENETIC PREDISPOSITION TO DISEASE; HEART CONDUCTION SYSTEM; HEART RATE; HUMANS; ION CHANNEL GATING; KINETICS; LONG QT SYNDROME; MALE; MARKOV CHAINS; MODELS, CARDIOVASCULAR; MUSCLE PROTEINS; MUTATION; PEDIGREE; PHENOTYPE; PROTEIN CONFORMATION; SODIUM; SODIUM CHANNELS;

EID: 53049109133     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.4956     Document Type: Article

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