Application of hydrophilic interaction chromatography for simultaneous separation of six impurities of mildronate substance

Journal of Pharmaceutical and Biomedical Analysis

Volumn 48, Issue 3, 2008, Pages 649-656

  Hmelnickis, Juris ^a,b   Pugovičs, Osvalds ^c   Kažoka, Helena ^c   Viksna, Arturs ^b   Susinskis, Igors ^a   Kokums, Kaspars ^a  

^a Join stock company Grindeks   (Latvia)

^b UNIVERSITY OF LATVIA   (Latvia)

^c LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

Author keywords

HILIC; HPLC; Mildronate; Polar stationary phases; Retention factor

Indexed keywords

AMINE; AMPHOLYTE; BETAINE DERIVATIVE; MILDRONATE; NITRILE; SILICON DIOXIDE; SULFOBETAINE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CHEMICAL STRUCTURE; CHROMATOGRAPHY; DRUG IMPURITY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; HYDROPHILICITY; PH; PRIORITY JOURNAL; SEPARATION TECHNIQUE; SOLUTE; VALIDATION PROCESS;

ACETONITRILES; BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; HYDROGEN-ION CONCENTRATION; METHYLHYDRAZINES; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TIME FACTORS; WATER;

EID: 53049086817     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.06.011     Document Type: Article

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