Effects of different glycerol feeding strategies on S-adenosyl-l-methionine biosynthesis by PGAP-driven Pichia pastoris overexpressing methionine adenosyltransferase

Journal of Biotechnology

Volumn 137, Issue 1-4, 2008, Pages 44-49

  Hu, Xiao Qing ^a   Chu, Ju ^a   Zhang, Zhuo ^a   Zhang, Si Liang ^a   Zhuang, Ying Ping ^a   Wang, Yong Hong ^a   Guo, Mei Jin ^a   Chen, Hua Xin ^a   Yuan, Zhong Yi ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Oxygen transfer rate; PGAP; Pulsed feeding; Residual glycerol; S adenosyl l methionine; Volumetric oxygen transfer coefficient

Indexed keywords

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; GLYCEROL;

ADENOSYLTRANSFERASE; FEEDING STRATEGIES; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; OXYGEN TRANSFER RATE; PGAP; PICHIA PASTORIS; PULSED FEEDING; RESIDUAL GLYCEROL; S-ADENOSYL-L-METHIONINE; VOLUMETRIC OXYGEN TRANSFER COEFFICIENT;

GALLIUM ALLOYS;

DISSOLVED OXYGEN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCEROL; METHIONINE ADENOSYLTRANSFERASE; S ADENOSYLMETHIONINE;

ANALYTIC METHOD; ARTICLE; BIOMASS; BIOREACTOR; BIOSYNTHESIS; CARBON SOURCE; CELL DENSITY; FED BATCH CULTURE; INOCULATION; NONHUMAN; OXYGEN CONSUMPTION; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BIOREACTORS; CULTURE MEDIA; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; GLYCEROL; METHIONINE ADENOSYLTRANSFERASE; OXYGEN; PICHIA; S-ADENOSYLMETHIONINE;

PICHIA PASTORIS;

EID: 52949134791     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2008.04.009     Document Type: Article

References (23)

1. Brierley R.A. Secretion of recombinant human insulin-like growth factor I (IGF-I). In: Higgins D.R., and Cregg J.M. (Eds). Methods in Molecular Biology (1998), Humana Press, Totowa, NJ 149-177
2. Chen H., Chu J., Zhang S., Zhuang Y., Qian J., Wang Y., and Hu X. Intracellular expression of Vitreoscilla hemoglobin improves S-adenosylmethionine production in a recombinant Pichia pastoris. Appl. Microbiol. Biotechnol. 74 6 (2007) 1205-1212
3. Chiruvolu V., Eskridge K., Cregg J., and Meagher M. Effects of glycerol concentration and pH on growth of recombinant Pichia pastoris yeast. Appl. Biochem. Biotechnol. 75 (1998) 163-173
4. Chung J.D. Design of metabolic feed controllers: application to high density fermentations of Pichia pastoris. Biotechnol. Bioeng. 68 (2000) 298-307
5. Dorresteijn R.C., Gooijer C.D., Tramper J., and Beuvery E.C. A method for simultaneous determination of solubility and transfer coefficient of oxygen in aqueous media. Biotechnol. Bioeng. 34 (1994) 149-154
6. He J., Deng J., Zheng Y., and Gu J. A synergistic effect on the production of S-adenosyl-l-methionine in Pichia pastoris by knocking in of S-adenosyl-l-methionine synthase and knocking out of cystathionine-β synthase. J. Biotechnol. 126 4 (2006) 519-527
7. Heo J.H., Hong W.K., Cho E.Y., Kim M.W., Kim J.Y., Kim C.H., Rhee S.K., and Kang H.A. Properties of the Hansenula polymorpha-derived constitutive GAP promoter, assessed using an HSA reporter gene. FEMS Yeast Res. 4 (2003) 175-184
8. Higgins D.R., and Cregg J.M. Introduction to Pichia pastoris. Pichia Protocols (1998), Humana Press, Totowa, NJ pp. 1-16
9. Hu X.Q., Chu J., Zhang S.L., Zhuang Y.P., Wang Y.H., Zhu S., Zhu Z.G., and Yuan Z.Y. A novel feeding strategy during the production phase for enhancing the enzymatic synthesis of S-adenosyl-l-methionine by methylotrophic Pichia pastoris. Enzyme Microb. Technol. 40 (2007) 669-674
10. Li Z.J., Shukla V., Fordyce A.P., Pedersen A.G., Wenger K.S., and Marten M.R. The agitation effects on productivity in a production-scale fed-batch Aspergillus oryzae fermentation. Biotechnol. Prog. 18 (2002) 437-444
11. Lin J.P., Tian J., You J.F., Jin Z.H., Xu Z.N., and Cen P.L. An effective strategy for the co-production of S-adenosyl-l-methionine and glutathione by fed-batch fermentation. Biochem. Eng. J. 21 (2004) 19-25
12. Miller S.A., Cooper C.M., Fernstrom G.A., and Miller S.A. Performance of agitated gas-liquid contactors. Ind. Eng. Chem. 36 (1944) 504-509
13. Minning S., Serrano A., Ferrer P., Sola C., Schmid R.D., and Valero F. Optimization of the high-level production of Rhizopus oryzae lipase in Pichia pastoris. J. Biotechnol. 86 (2001) 59-70
14. Oolman T.O., and Blanch H.W. Bubble coalescence in stagnant liquids. Chem. Eng. Commun. 43 (1986) 237-261
15. Pierro D.D., Tavazzi B., Perno C.F., Bartolini M., Balestra E., Calio R., Giardina B., and Lazzarino G. An ion-pairing high-performance liquid chromatographic method for the direct simultaneous determination of nucleotides, deoxynucleotides, nicotinic coenzymes, oxypurines, nucleosides, and bases in perchloric acid cell extracts. Anal. Biochem. 231 (1995) 407-412
16. Shiozaki S., Shimizu S., and Yamada H. Unusual intracellular accumulation of S-adenosyl-l-methionine by microorganisms. Agric. Biol. Chem. 48 (1984) 2293-2300
17. Stratton J., Chiruvolu V., and Meagher M. High cell-density fermentation. In: Higgins D.R., and Cregg J.M. (Eds). Methods in Molecular Biology (1998), Humana Press, Totowa, NJ 107-120
18. Verschoor H. Some aspects of the motion of swarm of gas bubbles rising through a vertical liquid column. Chem. Eng. R 28a (1952) 52-62
19. Wagner J., Danzin C., Huot-Olivier S., Claverie N., and Palfreyman M.G. High-performance liquid chromatographic analysis of S-adenosylmethionine and its metabolites in rat tissues: interrelationship with changes in biogenic catechol levels following treatment with l-DOPA. J. Chromatogr. 290 (1984) 247-262
20. Waterham H.R., Digan M.E., Koutz P.J., Lair S.V., and Cregg J.M. Isolation of the Pichia pastoris glyceraldehyde-3-phosphate dehydrogenase gene and regulation and use of its promoter. Gene 186 (1997) 37-44
21. Yu Z.L., Wu X.J., Li D.Y., Yang S., Zhou Z., Cai J., and Yuan Z.Y. Enhancement of the production of SAM by overexpression of SAM synthetase in Pichia pastoris. Acta Biochem. Biophys. Sin. 35 (2002) 127-132
22. Zhang W., Li Z.J., and Agblevor F.A. Microbubble fermentation of recombinant Pichia pastoris for human serum albumin production. Process Biochem. 40 (2005) 2073-2078
23. Zhou, J., Chu, J., Wang, Y.H., Zhang, S.L., Zhuang, Y.P., Yuan, Z.Y., 2007. Purification and properties of Saccharomyces cerevisiae S-adenosylmethionine synthetase expressed in recombinant Pichia pastoris. World J. Microbiol. Biotechnol. published online.