Acetaminophen: The case for a link to neurodegenerative diseases

Medical Hypotheses

Volumn 71, Issue 5, 2008, Pages 813-814

  Sharpe, Richard J ^a  

^a Bridgewater State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL;

AGING; ALZHEIMER DISEASE; CELL LOSS; DEGENERATIVE DISEASE; DRUG MECHANISM; DRUG OVERDOSE; DRUG PENETRATION; GASTROINTESTINAL TOXICITY; HEREDITY; HUMAN; LETTER; LIVER FAILURE; LIVER TOXICITY; NERVE CELL LESION; OSTEOARTHRITIS; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; REYE SYNDROME;

ACETAMINOPHEN; AGING; ANALGESICS; ANIMALS; HUMANS; MODELS, BIOLOGICAL; MODELS, THEORETICAL; NEURODEGENERATIVE DISEASES; NEURONS; RETINAL DEGENERATION;

EID: 52949131540     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2008.07.002     Document Type: Letter

References (10)

1. Silverman J.M., Raiford K., Edland S., Fillenbaum G., Morris J.C., Clark C.M., et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part VI. Family history assessment: a multicenter study of first-degree relatives of Alzheimer's disease probands and nondemented spouse controls. Neurology 44 7 (1994) 1253-1259
2. Bennett D.A., Beckett L.A., Murray A.M., Shannon K.M., Goetz C.G., Pilgrim D.M., et al. Prevalence of parkinsonian signs and associated mortality in a community population of older people. N Engl J Med 334 2 (1996) 71-76
3. Lim A., Tsuang D., Kukull W., Nochlin D., Leverenz J., McCormick W., et al. Clinico-neuropathological correlation of Alzheimer's disease in a community-based case series. J Am Geriatr Soc 47 5 (1999) 564-569
4. Dunnett S.B., and Björklund A. Prospects for new restorative and neuroprotective treatments in Parkinson's disease. Nature 399 6738 Suppl (1999) A32-A39
5. Hurwitz E.S., Barrett M.J., Bregman D., Gunn W.J., Schonberger L.B., Fairweather W.R., et al. Public Health Service study on Reye's syndrome and medications. Report of the pilot phase. N Engl J Med 313 14 (1985) 849-857
6. Flegal K.M., Carroll M.D., Ogden C.L., and Johnson C.L. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 288 14 (2002) 1723-1727
7. Makin A.J., Wendon J., and Williams R. A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987-1993). Gastroenterology 109 6 (1995) 1907-1916
8. Smith M.A., and Perry G. Free radical damage, iron, and Alzheimer's disease. J Neurol Sci Suppl. 134 (1995) 92-94
9. de la Asuncion J.G., Millan A., Pla R., Bruseghini L., Esteras A., Pallardo F.V., et al. Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. FASEB J 10 2 (1996) 333-338
10. Benzi G., and Moretti A. Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system. Free Radic Biol Med 19 1 (1995) 77-101