Design, synthesis, and docking studies of novel benzopyrone derivatives as H1-antihistaminic agents

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 19, 2008, Pages 9009-9017

  Farag, Nahla A ^a   Mohamed, Shadia R ^a   Soliman, Gamal A H ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b Cairo University   (Egypt)

Author keywords

2H 1 benzopyran 2 one; Docking; Histamine binding protein; Histamine H1 antagonists; Histamine N methyltransferase; Internal coordinate mechanics (ICM)

Indexed keywords

AMODIAQUINE; BENZOPYRONE DERIVATIVE; CYCLIZINE; DIPHENHYDRAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE METHYLTRANSFERASE; METODICLOROFEN; PHENIRAMINE; PYRONE DERIVATIVE; TACRINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; GUINEA PIG; ILEUM CONTRACTION; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ALGORITHMS; ANIMALS; BINDING SITES; COUMARINS; DRUG DESIGN; GUINEA PIGS; HISTAMINE; HISTAMINE ANTAGONISTS; HISTAMINE H1 ANTAGONISTS; HISTAMINE N-METHYLTRANSFERASE; MALE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 52949124802     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.039     Document Type: Article

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