Transport of valproate at intestinal epithelial (Caco-2) and brain endothelial (RBE4) cells: Mechanism and substrate specificity

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 2, 2008, Pages 486-492

  Fischer, Wiebke ^a   Praetor, Katrin ^a   Metzner, Linda ^a   Neubert, Reinhard H H ^a   Brandsch, Matthias ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Caco 2 cells; Drug delivery; Membrane transport; RBE4 cells; Valproate; Valproic acid

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ACETIC ACID; ANTICONVULSIVE AGENT; ASPARTIC ACID; BENZOIC ACID; BUTYRIC ACID; CALCIUM ION; CARBOXYLIC ACID DERIVATIVE; CARNITINE; CEFADROXIL; CHLORIDE; CLONIDINE; CODEINE; DICLOFENAC; DIPYRONE; ESTRONE SULFATE; GLUTAMIC ACID; HEXANOIC ACID; IBUPROFEN; MAGNESIUM ION; MONOCARBOXYLATE TRANSPORTER 1; POTASSIUM ION; PROPIONIC ACID; RIFAMPICIN; SALICYLIC ACID; SODIUM ION; TETRYLAMMONIUM; UNINDEXED DRUG; VALPROIC ACID; VERAPAMIL;

APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; BLOOD BRAIN BARRIER; CELL STRAIN CACO 2; CELL TYPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG TRANSPORT; DRUG UPTAKE; ENDOTHELIUM CELL; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; MONOLAYER CULTURE; TARGET CELL;

ANTICONVULSANTS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CACO-2 CELLS; ENDOTHELIAL CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MONOCARBOXYLIC ACID TRANSPORTERS; SUBSTRATE SPECIFICITY; SYMPORTERS; VALPROIC ACID;

EID: 52949115270     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.05.022     Document Type: Article

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