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Volumn 17, Issue 10, 2008, Pages 1501-1516

Novel drugs for Renal cell carcinoma

Author keywords

Axitinib; Bevacizumab; Ceditanib; Everolimus; Mammalian target of rapamycin kinase; Pazopanib; Renal cell carcinoma; Sorafenib; Sunitinib; Targeted therapy; Temsirolimus; Tyrosine kinase inhibitors; VEGF; Volociximab

Indexed keywords

AFLIBERCEPT; ALPHA INTERFERON; ALPHA2A INTERFERON; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; AXITINIB; BEVACIZUMAB; CANCER VACCINE; CEDIRANIB; CYTOTOXIC AGENT; DOXORUBICIN; ERLOTINIB; EVEROLIMUS; GEMCITABINE; INTERLEUKIN 2; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PAZOPANIB; PLACEBO; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; TEMSIROLIMUS; UNCLASSIFIED DRUG; VASCULOTROPIN ANTIBODY; VASCULOTROPIN INHIBITOR; VOLOCIXIMAB;

EID: 52949089716     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.17.10.1501     Document Type: Review
Times cited : (4)

References (88)
  • 1
    • 52949089993 scopus 로고    scopus 로고
    • International Agency for Research on Cancer
    • International Agency for Research on Cancer
  • 5
    • 16644373473 scopus 로고    scopus 로고
    • Role of VHL gene mutation in human cancer
    • Kim WY, Kaelin WG. Role of VHL gene mutation in human cancer. J Clin Oncol 2004;22(24):4991-5004
    • (2004) J Clin Oncol , vol.22 , Issue.24 , pp. 4991-5004
    • Kim, W.Y.1    Kaelin, W.G.2
  • 6
    • 0031776704 scopus 로고    scopus 로고
    • Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumourigenesis
    • Clifford SC, Prowse AH, Affara NA, et al. Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis. Genes Chromosomes Cancer 1998;22(3):200-9
    • (1998) Genes Chromosomes Cancer , vol.22 , Issue.3 , pp. 200-209
    • Clifford, S.C.1    Prowse, A.H.2    Affara, N.A.3
  • 7
    • 0034682783 scopus 로고    scopus 로고
    • Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
    • Cockman ME, Masson N, Mole DR, et al. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem 2000;275(33):25733-41
    • (2000) J Biol Chem , vol.275 , Issue.33 , pp. 25733-25741
    • Cockman, M.E.1    Masson, N.2    Mole, D.R.3
  • 8
    • 0036645598 scopus 로고    scopus 로고
    • Vascular endothelial growth factor overexpression is correlated with von Hippel-Lindau tumor suppressor gene inactivation in patients with sporadic renal cell carcinoma
    • Igarashi H, Esumi M, Ishida H, et al. Vascular endothelial growth factor overexpression is correlated with von Hippel-Lindau tumor suppressor gene inactivation in patients with sporadic renal cell carcinoma. Cancer 2002;95(1):47-53
    • (2002) Cancer , vol.95 , Issue.1 , pp. 47-53
    • Igarashi, H.1    Esumi, M.2    Ishida, H.3
  • 9
    • 85047688292 scopus 로고    scopus 로고
    • Expression of platelet-derived growth factor-alpha alpha receptor is associated with tumor progression in clear cell renal cell carcinoma
    • Sulzbacher I, Birner P, Traxler M, et al. Expression of platelet-derived growth factor-alpha alpha receptor is associated with tumor progression in clear cell renal cell carcinoma. Am J Clin Pathol 2003;120(1):107-12.
    • (2003) Am J Clin Pathol , vol.120 , Issue.1 , pp. 107-112
    • Sulzbacher, I.1    Birner, P.2    Traxler, M.3
  • 10
    • 0034680008 scopus 로고    scopus 로고
    • The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila
    • Scanga SE, Ruel L, Binari RC, et al. The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 2000;19(35):3971-7
    • (2000) Oncogene , vol.19 , Issue.35 , pp. 3971-3977
    • Scanga, S.E.1    Ruel, L.2    Binari, R.C.3
  • 11
    • 40949118437 scopus 로고    scopus 로고
    • an inhibitor of mammalian target of rapamycin
    • Rini BI. Temsirolimus, an inhibitor of mammalian target of rapamycin. Clin Cancer Res 2008;14(5):1286-90
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1286-1290
    • Temsirolimus, R.B.I.1
  • 13
    • 0037468875 scopus 로고    scopus 로고
    • Discovery of 5-[5-fl uoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2, 4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase
    • Sun L, Liang C, Shirazian S, et al. Discovery of 5-[5-fl uoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2, 4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem 2003;46(7):1116-9
    • (2003) J Med Chem , vol.46 , Issue.7 , pp. 1116-1119
    • Sun, L.1    Liang, C.2    Shirazian, S.3
  • 14
    • 33947423448 scopus 로고    scopus 로고
    • Approval summary: Sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced enal cell carcinoma
    • Goodman VL, Rock EP, Dagher R, et al. Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced enal cell carcinoma. Clin Cancer Res 2007;13(5):1367-73
    • (2007) Clin Cancer Res , vol.13 , Issue.5 , pp. 1367-1373
    • Goodman, V.L.1    Rock, E.P.2    Dagher, R.3
  • 16
    • 14644415949 scopus 로고    scopus 로고
    • Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
    • Rini BI, Small EJ. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J Clin Oncol 2005;23(5):1028-43
    • (2005) J Clin Oncol , vol.23 , Issue.5 , pp. 1028-1043
    • Rini, B.I.1    Small, E.J.2
  • 17
    • 34250156738 scopus 로고    scopus 로고
    • Sunitinib (Sutent): A novel agent for the treatment of metastatic renal cell carcinoma
    • Chouhan JD, Zamarripa DE, Lai PH, et al. Sunitinib (Sutent): a novel agent for the treatment of metastatic renal cell carcinoma. J Oncol Pharm Pract 2007;13(1):5-15
    • (2007) J Oncol Pharm Pract , vol.13 , Issue.1 , pp. 5-15
    • Chouhan, J.D.1    Zamarripa, D.E.2    Lai, P.H.3
  • 18
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003;9(1):327-37
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 19
    • 23844524757 scopus 로고    scopus 로고
    • Early antiangiogenic activity of SU11248 evaluated in vivo by dynamic contrast-enhanced magnetic resonance imaging in an experimental model of colon carcinoma
    • Marzola P, Degrassi A, Calderan L, et al. Early antiangiogenic activity of SU11248 evaluated in vivo by dynamic contrast-enhanced magnetic resonance imaging in an experimental model of colon carcinoma. Clin Cancer Res 2005;11(16):5827-32
    • (2005) Clin Cancer Res , vol.11 , Issue.16 , pp. 5827-5832
    • Marzola, P.1    Degrassi, A.2    Calderan, L.3
  • 20
    • 33746625622 scopus 로고    scopus 로고
    • Effect of SU11248 on gastrointestinal stromal tumor-T1 cells: Enhancement of growth inhibition via inhibition of 3-kinase/Akt/mammalian target of rapamycin signaling
    • Ikezoe T, Yang Y, Nishioka C, et al. Effect of SU11248 on gastrointestinal stromal tumor-T1 cells: enhancement of growth inhibition via inhibition of 3-kinase/Akt/mammalian target of rapamycin signaling. Cancer Sci 2006;97(9):45-951
    • (2006) Cancer Sci , vol.97 , Issue.9 , pp. 45-951
    • Ikezoe, T.1    Yang, Y.2    Nishioka, C.3
  • 21
    • 33749544080 scopus 로고    scopus 로고
    • An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases
    • Kim DW, Jo YS, Jung HS, et al. An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases. J Clin Endocrinol Metab 2006;91(10):4070-6
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.10 , pp. 4070-4076
    • Kim, D.W.1    Jo, Y.S.2    Jung, H.S.3
  • 22
    • 33748293111 scopus 로고    scopus 로고
    • SU14813: A novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity
    • Patyna S, Laird AD, Mendel DB, et al. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther 2006; 5 (7): 1774-82
    • (2006) Mol Cancer Ther , vol.5 , Issue.7 , pp. 1774-1782
    • Patyna, S.1    Laird, A.D.2    Mendel, D.B.3
  • 23
    • 52949101310 scopus 로고    scopus 로고
    • Anonymous. Sutent-package insert, Pfizer; 2006
    • Anonymous. Sutent-package insert, Pfizer; 2006
  • 25
    • 33646108821 scopus 로고    scopus 로고
    • Effect of food on the pharmacokinetics of sunitinib malate (SU11248), a multi-targeted receptor tyrosine kinase inhibitor: Results from a phase I study in healthy subjects
    • Bello CL, Sherman L, Zhou J, et al. Effect of food on the pharmacokinetics of sunitinib malate (SU11248), a multi-targeted receptor tyrosine kinase inhibitor: results from a phase I study in healthy subjects. Anticancer Drugs 2006;17(3):353-8
    • (2006) Anticancer Drugs , vol.17 , Issue.3 , pp. 353-358
    • Bello, C.L.1    Sherman, L.2    Zhou, J.3
  • 26
    • 33644847440 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
    • Faivre S, Delbaldo C, Vera K, et al. Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 2006;24(1):25-35
    • (2006) J Clin Oncol , vol.24 , Issue.1 , pp. 25-35
    • Faivre, S.1    Delbaldo, C.2    Vera, K.3
  • 27
    • 19944431093 scopus 로고    scopus 로고
    • A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease
    • Fiedler W, Serve H, Dohner H, et al. A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Blood 2005;105(3):986-93
    • (2005) Blood , vol.105 , Issue.3 , pp. 986-993
    • Fiedler, W.1    Serve, H.2    Dohner, H.3
  • 28
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer RJ, Michaelson MD, Redman BG, et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006;24(1):16-24
    • (2006) J Clin Oncol , vol.24 , Issue.1 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3
  • 29
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • Motzer RJ, Rini BI, Bukowski RM, et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006;295(21):2516-24
    • (2006) JAMA , vol.295 , Issue.21 , pp. 2516-2524
    • Motzer, R.J.1    Rini, B.I.2    Bukowski, R.M.3
  • 30
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356(2):115-24
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 31
    • 48649094719 scopus 로고    scopus 로고
    • Overall survival with sunitinib versus interferon (IFN)-alfa as first-line treatment of metastatic renal cell carcinoma (mRCC)
    • Suppl
    • Figlin RA, Hutson TE, Tomczak P, et al. Overall survival with sunitinib versus interferon (IFN)-alfa as first-line treatment of metastatic renal cell carcinoma (mRCC). ASCO annual meeting proceedings [abstrart 5024]. J Clin Oncol 2008; 26 (Suppl)
    • (2008) ASCO annual meeting proceedings [abstrart 5024]. J Clin Oncol , vol.26
    • Figlin, R.A.1    Hutson, T.E.2    Tomczak, P.3
  • 32
    • 34147161209 scopus 로고    scopus 로고
    • Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006)
    • Murphy DA, Makonnen S, Lassoued W, et al. Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006). Am J Pathol 2006;169(5):1875-85
    • (2006) Am J Pathol , vol.169 , Issue.5 , pp. 1875-1885
    • Murphy, D.A.1    Makonnen, S.2    Lassoued, W.3
  • 33
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64(19):7099-109
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 34
    • 20044382799 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
    • Strumberg D, Richly H, Hilger RA, et al. Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J Clin Oncol 2005;23(5):965-72
    • (2005) J Clin Oncol , vol.23 , Issue.5 , pp. 965-972
    • Strumberg, D.1    Richly, H.2    Hilger, R.A.3
  • 35
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Christopher C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-109
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Christopher, C.2    Tang, L.3
  • 36
    • 23044510046 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors
    • Clark JW, Eder JP, Ryan D, et al. Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors. Clin Cancer Res 2005;11(15):5472-80
    • (2005) Clin Cancer Res , vol.11 , Issue.15 , pp. 5472-5480
    • Clark, J.W.1    Eder, J.P.2    Ryan, D.3
  • 37
    • 20344362911 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours
    • Awada A, Hendlisz A, Gil T, et al. Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours. Br J Cancer 2005;92(10):1855-61
    • (2005) Br J Cancer , vol.92 , Issue.10 , pp. 1855-1861
    • Awada, A.1    Hendlisz, A.2    Gil, T.3
  • 38
    • 27144527372 scopus 로고    scopus 로고
    • Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors
    • Moore M, Hirte HW, Siu L, et al. Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors. Ann Oncol 2005;16(10):1688-94
    • (2005) Ann Oncol , vol.16 , Issue.10 , pp. 1688-1694
    • Moore, M.1    Hirte, H.W.2    Siu, L.3
  • 39
    • 34250168681 scopus 로고    scopus 로고
    • Phase I trial of sorafenib in combination with IFN alpha-2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma
    • Escudier B, Lassau N, Angevin E, et al. Phase I trial of sorafenib in combination with IFN alpha-2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma. Clin Cancer Res 2007;13(6):1801-9
    • (2007) Clin Cancer Res , vol.13 , Issue.6 , pp. 1801-1809
    • Escudier, B.1    Lassau, N.2    Angevin, E.3
  • 40
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
    • Ratain MJ, Eisen T, Stadler WM, et al. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 2006;24(16):2505-12
    • (2006) J Clin Oncol , vol.24 , Issue.16 , pp. 2505-2512
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3
  • 41
    • 52949109162 scopus 로고    scopus 로고
    • Szczylik C, Demkow T, Staehler M, et al. Randomized phase II trial of first-line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: final results. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 25 (18S Suppl): 5025
    • Szczylik C, Demkow T, Staehler M, et al. Randomized phase II trial of first-line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: final results. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 25 (18S Suppl): 5025
  • 42
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007;356(2):125-34
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 43
    • 34250026980 scopus 로고    scopus 로고
    • Sorafenib TARGETs Clinical Trial Group. Effects of sorafenib on symptoms and quality of life: Results from a large randomized placebo-controlled study in renal cancer
    • Bukowski R, Cella D, Gondek K, et al. Sorafenib TARGETs Clinical Trial Group. Effects of sorafenib on symptoms and quality of life: results from a large randomized placebo-controlled study in renal cancer. Am J Clin Oncol 2007;30(3):220-7
    • (2007) Am J Clin Oncol , vol.30 , Issue.3 , pp. 220-227
    • Bukowski, R.1    Cella, D.2    Gondek, K.3
  • 45
    • 56249088721 scopus 로고    scopus 로고
    • A prospective trial of sorafenib in patients (pts) with metastatic clear cell renal cell carcinoma (mccRCC) refractory to prior sunitinib or bevacizumab
    • abstract 346
    • Rini BI, Hutson TE, Elson P, et al. A prospective trial of sorafenib in patients (pts) with metastatic clear cell renal cell carcinoma (mccRCC) refractory to prior sunitinib or bevacizumab [abstract 346]. 2008 ASCO Genitourinary Cancers Symposium
    • 2008 ASCO Genitourinary Cancers Symposium
    • Rini, B.I.1    Hutson, T.E.2    Elson, P.3
  • 46
    • 24944453855 scopus 로고    scopus 로고
    • Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results
    • Rugo HS, Herbst RS, Liu G, et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J Clin Oncol 2005;23(24):5474-83
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5474-5483
    • Rugo, H.S.1    Herbst, R.S.2    Liu, G.3
  • 47
    • 35448934762 scopus 로고    scopus 로고
    • Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study
    • Rixe O, Bukowski RM, Michaelson MD, et al. Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study. Lancet Oncol 2007;8(11):975-84
    • (2007) Lancet Oncol , vol.8 , Issue.11 , pp. 975-984
    • Rixe, O.1    Bukowski, R.M.2    Michaelson, M.D.3
  • 48
    • 55249127491 scopus 로고    scopus 로고
    • Sequential axitinib (AG-013736) therapy of patients (pts) with metastatic clear cell renal cell cancer (RCC) refractory to sunitinib and sorafenib, cytokines and sorafenib, or sorafenib alone [abstract 5127]
    • Dutcher JP, Wilding G, Hudes GR, et al. Sequential axitinib (AG-013736) therapy of patients (pts) with metastatic clear cell renal cell cancer (RCC) refractory to sunitinib and sorafenib, cytokines and sorafenib, or sorafenib alone [abstract 5127]. J Clin Oncol 2008;26(Suppl)
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Dutcher, J.P.1    Wilding, G.2    Hudes, G.R.3
  • 49
    • 52949147747 scopus 로고    scopus 로고
    • Axitinib (AG-013736) as second line therapy for metastatic renal cell cancer: AXIS trial, clinical protocol A4061032, Pfizer
    • Axitinib (AG-013736) as second line therapy for metastatic renal cell cancer: AXIS trial, clinical protocol A4061032, Pfizer
  • 50
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge SR, Kendrew J, Laurent F, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005;65(10):4389-400
    • (2005) Cancer Res , vol.65 , Issue.10 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Laurent, F.3
  • 52
    • 63449138139 scopus 로고    scopus 로고
    • Activity of cediranib (AZD2171) in patients (pts) with previously untreated metastatic renal cell cancer (RCC). A phase II trial of the PMH Consortium [abstract 5047]
    • Sridhar SS, MacKenzie MJ, Hotte SJ, et al. Activity of cediranib (AZD2171) in patients (pts) with previously untreated metastatic renal cell cancer (RCC). A phase II trial of the PMH Consortium [abstract 5047]. J Clin Oncol 2008;26(Suppl)
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Sridhar, S.S.1    MacKenzie, M.J.2    Hotte, S.J.3
  • 53
    • 34447322566 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
    • Kumar R, Knick VB, Rudolph SK, et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther 2007;6(7):2012-21
    • (2007) Mol Cancer Ther , vol.6 , Issue.7 , pp. 2012-2021
    • Kumar, R.1    Knick, V.B.2    Rudolph, S.K.3
  • 54
    • 33646258383 scopus 로고    scopus 로고
    • Safety, tolerability and pharmacokinetics of oral administration of GW786034 in pts with solid tumors [abstract 3012]
    • 195s
    • Hurwitz H, Dowlati A, Savage S, et al. Safety, tolerability and pharmacokinetics of oral administration of GW786034 in pts with solid tumors [abstract 3012]. J Clin Oncol 2005;23:195s
    • (2005) J Clin Oncol , vol.23
    • Hurwitz, H.1    Dowlati, A.2    Savage, S.3
  • 56
    • 0037392444 scopus 로고    scopus 로고
    • Issues and progress with protein kinase inhibitors for cancer treatment
    • Dancey J, Sausville EA. Issues and progress with protein kinase inhibitors for cancer treatment. Nat Rev Drug Discov 2003;2(4):296-313
    • (2003) Nat Rev Drug Discov , vol.2 , Issue.4 , pp. 296-313
    • Dancey, J.1    Sausville, E.A.2
  • 57
    • 17944377486 scopus 로고    scopus 로고
    • Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
    • Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci USA 2001;98(18):10314-9
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.18 , pp. 10314-10319
    • Neshat, M.S.1    Mellinghoff, I.K.2    Tran, C.3
  • 58
    • 2942735384 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
    • Raymond E, Alexandre J, Faivre S, et al. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 2004;22(12):2336-47
    • (2004) J Clin Oncol , vol.22 , Issue.12 , pp. 2336-2347
    • Raymond, E.1    Alexandre, J.2    Faivre, S.3
  • 59
    • 1542398693 scopus 로고    scopus 로고
    • Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
    • Atkins MB, Hidalgo M, Stadler WM, et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 2004;22(5):909-18
    • (2004) J Clin Oncol , vol.22 , Issue.5 , pp. 909-918
    • Atkins, M.B.1    Hidalgo, M.2    Stadler, W.M.3
  • 60
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • Motzer RJ, Bacik J, Murphy BA, et al. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002;20(1):289-96
    • (2002) J Clin Oncol , vol.20 , Issue.1 , pp. 289-296
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3
  • 61
    • 34249779568 scopus 로고    scopus 로고
    • Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007;356(22)-1271-81
    • Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007;356(22)-1271-81
  • 62
    • 33749002279 scopus 로고    scopus 로고
    • Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
    • Yee KW, Zeng Z, Konopleva M, et al. Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res 2006;12(17):5165-73
    • (2006) Clin Cancer Res , vol.12 , Issue.17 , pp. 5165-5173
    • Yee, K.W.1    Zeng, Z.2    Konopleva, M.3
  • 63
    • 43249086546 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors
    • O'Donnell A, Faivre S, Burris HA, et al. Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors. J Clin Oncol 2008;26(10):1588-95
    • (2008) J Clin Oncol , vol.26 , Issue.10 , pp. 1588-1595
    • O'Donnell, A.1    Faivre, S.2    Burris, H.A.3
  • 65
    • 52949150040 scopus 로고    scopus 로고
    • RAD001 vs placebo in patients with metastatic renal cell carcinoma (RCC) after progression on VFGFr-TKI therapy: Results from a randomized, double-blind, multicenter phase-III study [abstr LBA5026]
    • Motzer RJ, Escudier B, Oudard S, et al. RAD001 vs placebo in patients with metastatic renal cell carcinoma (RCC) after progression on VFGFr-TKI therapy: results from a randomized, double-blind, multicenter phase-III study [abstr LBA5026]. J Clin Oncol 2008;26(Suppl)
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 66
    • 0032848409 scopus 로고    scopus 로고
    • Neutralizing anti-vascular endothelial growth factor antibody inhibits further growth of established prostate cancer and merastases in a pre-clinical model
    • Melnyk O, Zimmerman M, Kim KJ, et al. Neutralizing anti-vascular endothelial growth factor antibody inhibits further growth of established prostate cancer and merastases in a pre-clinical model. J Urol 1999;161(3):960-3
    • (1999) J Urol , vol.161 , Issue.3 , pp. 960-963
    • Melnyk, O.1    Zimmerman, M.2    Kim, K.J.3
  • 67
    • 0035253739 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • Gordon MS, Margolin K, Talpaz M, et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 2001;19(3):843-50
    • (2001) J Clin Oncol , vol.19 , Issue.3 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3
  • 68
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC, Haworth L, Sherry RM, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003;349(5):427-34
    • (2003) N Engl J Med , vol.349 , Issue.5 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 69
    • 35648938219 scopus 로고    scopus 로고
    • Randomized phase II study of erlotinib, combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer
    • Bukowski RM, Kabbinavar FF, Figlin RA, et al. Randomized phase II study of erlotinib, combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer. J Clin Oncol 2007;25(29):4536-41
    • (2007) J Clin Oncol , vol.25 , Issue.29 , pp. 4536-4541
    • Bukowski, R.M.1    Kabbinavar, F.F.2    Figlin, R.A.3
  • 70
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
    • Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007;370(9605):2103-11
    • (2007) Lancet , vol.370 , Issue.9605 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 71
    • 48749092867 scopus 로고    scopus 로고
    • First-line bevacizumab combined with reduced dose interferon-alpha2a is active in patients with metastatic renal cell carcinoma
    • Melichar B, Koralewski P, Ravaud A, et al. First-line bevacizumab combined with reduced dose interferon-alpha2a is active in patients with metastatic renal cell carcinoma. Ann Oncol 2008;19(8):1470-6
    • (2008) Ann Oncol , vol.19 , Issue.8 , pp. 1470-1476
    • Melichar, B.1    Koralewski, P.2    Ravaud, A.3
  • 72
    • 43249085165 scopus 로고    scopus 로고
    • CALGB 90206: A phase III trial of bevacizumab plus interferon-alpha versus interferon-alpha monotherapy in metastatic renal cell carcinoma
    • abstract 350
    • Rini BL, Halabi S, Rosenberg JE, et al. CALGB 90206: a phase III trial of bevacizumab plus interferon-alpha versus interferon-alpha monotherapy in metastatic renal cell carcinoma [abstract 350]. 2008 ASCO Genitourinary Cancers Symposium
    • 2008 ASCO Genitourinary Cancers Symposium
    • Rini, B.L.1    Halabi, S.2    Rosenberg, J.E.3
  • 73
    • 21244475869 scopus 로고    scopus 로고
    • A phase I dose-escalation study of anti-α5β1 integrin monoclonal antibody (M200) in patients with refractory solid tumors [abstract 166]
    • Ricart A, Liu G, Tolcher A, et al. A phase I dose-escalation study of anti-α5β1 integrin monoclonal antibody (M200) in patients with refractory solid tumors [abstract 166]. Eur J Cancer 2004;2(Suppl):52
    • (2004) Eur J Cancer , vol.2 , Issue.SUPPL. , pp. 52
    • Ricart, A.1    Liu, G.2    Tolcher, A.3
  • 74
    • 52949127295 scopus 로고    scopus 로고
    • Figlin RA, Kondagunta GV, Yazji S, et al. Phase II study of volociximab (M200), an α5β1 anti-integrin antibody in refractory metastatic dear cell renal cell cancer (RCC) 2006 ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol 2006;24(18S Suppl):535
    • Figlin RA, Kondagunta GV, Yazji S, et al. Phase II study of volociximab (M200), an α5β1 anti-integrin antibody in refractory metastatic dear cell renal cell cancer (RCC) 2006 ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol 2006;24(18S Suppl):535
  • 75
    • 33749433380 scopus 로고    scopus 로고
    • The pathology of renal epithelial neoplasms
    • Reuter VE. The pathology of renal epithelial neoplasms. Semin Oncol 2006;33(5):534-43
    • (2006) Semin Oncol , vol.33 , Issue.5 , pp. 534-543
    • Reuter, V.E.1
  • 76
    • 37849001813 scopus 로고    scopus 로고
    • Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma
    • Choueiri TK, Plantade A, Elson P, et al. Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. J Clin Oncol 2008;26(1):127-31
    • (2008) J Clin Oncol , vol.26 , Issue.1 , pp. 127-131
    • Choueiri, T.K.1    Plantade, A.2    Elson, P.3
  • 77
    • 52949136961 scopus 로고    scopus 로고
    • Metastatic renal cell carcinoma (mRCC) patients (pts) with sarcomatoid features treated with VEGF-targeted therapy [abstract 5102]
    • Golshayan AR, George S, Heng DY, et al. Metastatic renal cell carcinoma (mRCC) patients (pts) with sarcomatoid features treated with VEGF-targeted therapy [abstract 5102]. J Clin Oncol 2008:26(20 Suppl)
    • (2008) J Clin Oncol , vol.26 , Issue.20 SUPPL.
    • Golshayan, A.R.1    George, S.2    Heng, D.Y.3
  • 78
    • 4844231761 scopus 로고    scopus 로고
    • Active chemotherapy for sarcomatoid and rapidly progressing renal cell carcinoma
    • Nanus DM, Garino A, Milowsky MI, et al. Active chemotherapy for sarcomatoid and rapidly progressing renal cell carcinoma. Cancer 2004;101(7):1545-51
    • (2004) Cancer , vol.101 , Issue.7 , pp. 1545-1551
    • Nanus, D.M.1    Garino, A.2    Milowsky, M.I.3
  • 79
    • 52949115615 scopus 로고    scopus 로고
    • Effect of temsirolimus versus interferon-α on survival of patients with advanced renal cell carcinoma of different tumor histologies [abstract 384)
    • Dutcher JP, De Souza P, Figlin R, et al. Effect of temsirolimus versus interferon-α on survival of patients with advanced renal cell carcinoma of different tumor histologies [abstract 384). 2008 ASCO Genitourinary Cancers Symposium
    • (2008) ASCO Genitourinary Cancers Symposium
    • Dutcher, J.P.1    De Souza, P.2    Figlin, R.3
  • 80
    • 0028928749 scopus 로고
    • Chemotherapy for advanced renal-cell carcinoma: 1983-1993
    • Yagoda A, Abi-Rached B, Petrylak D. Chemotherapy for advanced renal-cell carcinoma: 1983-1993. Semin Oncol 1995;22(1):42-60
    • (1995) Semin Oncol , vol.22 , Issue.1 , pp. 42-60
    • Yagoda, A.1    Abi-Rached, B.2    Petrylak, D.3
  • 81
    • 75649117254 scopus 로고    scopus 로고
    • Phase I trial of a PSMA DNA vaccine for patients (pts) with good risk renal cell carcinoma (RCC) [abstract 16073]
    • Slovin SF, Motzer RJ, Jefferson M, et al. Phase I trial of a PSMA DNA vaccine for patients (pts) with good risk renal cell carcinoma (RCC) [abstract 16073]. J Clin Oncol 2008;26(20 Suppl)
    • (2008) J Clin Oncol , vol.26 , Issue.20 SUPPL.
    • Slovin, S.F.1    Motzer, R.J.2    Jefferson, M.3
  • 82
    • 52949141821 scopus 로고    scopus 로고
    • Phase I/II study of the tumor-targeting human L19-IL2 monoclonal antibody-cytokine fusion protein in patients with advanced renal cell carcinoma [abstract 16032]
    • Suppl
    • Johannsen M, Roemer A, Spitaleri G, et al. Phase I/II study of the tumor-targeting human L19-IL2 monoclonal antibody-cytokine fusion protein in patients with advanced renal cell carcinoma [abstract 16032]. J Clin Oncol 1008;26(Suppl)
    • J Clin Oncol 1008 , vol.26
    • Johannsen, M.1    Roemer, A.2    Spitaleri, G.3
  • 83
    • 52949119885 scopus 로고    scopus 로고
    • Dupont J, Schwartz L, Koutcher J, et al. Phase I and pharmacokinetic study of VEGF Trap administered subcutaneously (sc) to patients (pts) with advanced solid malignancies. 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol22(14S Suppl):3009
    • Dupont J, Schwartz L, Koutcher J, et al. Phase I and pharmacokinetic study of VEGF Trap administered subcutaneously (sc) to patients (pts) with advanced solid malignancies. 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol22(14S Suppl):3009
  • 84
    • 52949112592 scopus 로고    scopus 로고
    • Dupont J, Rothenberg ML, Spriggs DR, et al. Safety and pharmacokinetics of intravenous VEGT Trap in a phase I clinical trial of patients with advanced solid tumors. 2005 ASCO Annual Meeting Proceedings. J Clin Oncol23(16S Suppl) (Pt I of II):3029
    • Dupont J, Rothenberg ML, Spriggs DR, et al. Safety and pharmacokinetics of intravenous VEGT Trap in a phase I clinical trial of patients with advanced solid tumors. 2005 ASCO Annual Meeting Proceedings. J Clin Oncol23(16S Suppl) (Pt I of II):3029
  • 85
    • 34548263735 scopus 로고    scopus 로고
    • Phase II trial of sorafenib plus interferon alfa-2b as first- or second-line therapy in patients with metastatic renal cell cancer
    • Gollob JA, Rathmell WK, Richmond TM, et al. Phase II trial of sorafenib plus interferon alfa-2b as first- or second-line therapy in patients with metastatic renal cell cancer. J Clin Oncol 2007;25(22):3288-95
    • (2007) J Clin Oncol , vol.25 , Issue.22 , pp. 3288-3295
    • Gollob, J.A.1    Rathmell, W.K.2    Richmond, T.M.3
  • 86
    • 84872801066 scopus 로고    scopus 로고
    • Temsirolimus (TEM) in metastatic renal cell carcinoma (mRCC): Safety and efficacy in patients (pts) previously treated with VEGF-targeted therapy
    • abstract 3531
    • Wood L, Bukowski RM, Dreicer R, et al. Temsirolimus (TEM) in metastatic renal cell carcinoma (mRCC): safety and efficacy in patients (pts) previously treated with VEGF-targeted therapy [abstract 3531. 2008 ASCO Genitourinary Cancers Symposium
    • 2008 ASCO Genitourinary Cancers Symposium
    • Wood, L.1    Bukowski, R.M.2    Dreicer, R.3
  • 87
    • 65749102918 scopus 로고    scopus 로고
    • Neoadjuvant therapy with sorafenib for locally advanced renal cell carcinoma (RCC)
    • abstract 370
    • Radimell K, Amin C, Wallen E, et al. Neoadjuvant therapy with sorafenib for locally advanced renal cell carcinoma (RCC) [abstract 370]. 2008 ASCO Genitourinary Cancers Symposium
    • 2008 ASCO Genitourinary Cancers Symposium
    • Radimell, K.1    Amin, C.2    Wallen, E.3
  • 88
    • 52949148141 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF) 1α and 2α levels in cell lines and human tumor predicts response to sunitinib in renal cell carcinoma (RCC) [abstract 5008]
    • Patel PH, Chadalavada RS, Ishill NM, et al. Hypoxia-inducible factor (HIF) 1α and 2α levels in cell lines and human tumor predicts response to sunitinib in renal cell carcinoma (RCC) [abstract 5008]. J Clin Oncol 2008;26(Suppl)
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Patel, P.H.1    Chadalavada, R.S.2    Ishill, N.M.3


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