Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men

American Journal of Physiology - Endocrinology and Metabolism

Volumn 295, Issue 2, 2008, Pages

  Moro, Cedric ^a,d   Pillard, Fabien ^a,c,d   De Glisezinski, Isabelle ^a,c,d   Klimcakova, Eva ^d   Crampes, Francois ^a,c,d   Thalamas, Claire ^a,e   Harant, Isabelle ^a,c,d   Marques, Marie Adeline ^a   Lafontan, Max ^a,d   Berlan, Michel ^a,b,d  

^a INSERM   (France)

^b TOULOUSE UNIVERSITY HOSPITAL   (France)

^c CHU PURPAN   (France)

^d Franco Czech Laboratory for Clinical Research on Obesity   (Czech Republic)

^e Hôpital Pur Pan   (France)

Author keywords

Atrial natriuretic peptide; Insulin; Microdialysis; Tertatolol

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BETA ADRENERGIC RECEPTOR; FATTY ACID; GLYCEROL; INSULIN; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; PHENTOLAMINE; PROPANOLAMINE DERIVATIVE; TERTATOLOL; THIOPHENE DERIVATIVE;

ADULT; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CATECHOLAMINE BLOOD LEVEL; CLINICAL ARTICLE; EXERCISE; FATTY ACID BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIPID METABOLISM; LIPOLYSIS; MALE; MICRODIALYSIS; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SUBCUTANEOUS FAT; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; GLUCOSE BLOOD LEVEL; METABOLISM; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ADULT; ATRIAL NATRIURETIC FACTOR; BLOOD GLUCOSE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; EXERCISE; GLYCEROL; HUMANS; INSULIN; LIPID MOBILIZATION; MALE; OVERWEIGHT; PHENTOLAMINE; PROPANOLAMINES; SUBCUTANEOUS FAT; THIOPHENES;

EID: 52649133377     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90227.2008     Document Type: Article

References (38)

1. Arner P, Kriegholm E, Engfeldt P, Bolinder J. Adrenergic regulation of lipolysis in situ at rest and during exercise. J Clin Invest 85: 893-898, 1990.
2. Berlan M, Lafontan M. The alpha 2-adrenergic receptor of human fat cells: comparative study of alpha 2-adrenergic radioligand binding and biological response. J Physiol 78: 279-287, 1982.
3. Berlin I, Lechat P, Deray G, Landault C, Maistre G, Chermat V, Brouard R, Ressayre C, Puech AJ. Beta-adrenoceptor blockade potentiates acute exercise-induced release of atrial natriuretic peptide by increasing atrial diameter in normotensive healthy subjects. Eur J Clin Pharmacol 44: 127-133, 1993.
4. Bernst E, Gutmann I. Ethanol determination with alcohol deshydrogenase and NAD. In: Methods of Enzymatic Analysis, edited by Bergmeyer HU. Weinheim, Germany: Verlag Chemie, 1974, vol. 3, p.1499-1505.
5. Birkenfeld AL, Boschmann M, Moro C, Adams F, Heusser K, Franke G, Berlan M, Luft FC, Lafontan M, Jordan J. Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans. J Clin Endocrinol Metab 90: 3622-3628, 2005.
6. Bousquet-Melou A, Galitzky J, Lafontan M, Berlan M. Control of lipolysis in intra-abdominal fat cells of non-human primates: comparison with humans. J Lipid Res 36: 451-461, 1995.
7. Bradley DC, Kaslow HR. Radiometric assays for glycerol, glucose, and glycogen. Anal Biochem 180: 11-16, 1989.
8. De Glisezinski I, Marion-Latard F, Berlan M, Hejnova J, Cottetemard JM, Riviere D, Stich V, Crampes F. Lack of α2-adrenergic antilipolytic effect during exercise in subcutaneous adipose tissue of trained men. J Appl Physiol 91: 1760-1765, 2001.
9. Felländer G, Linde B, Bolinder J. Evaluation of the microdialysis ethanol technique for monitoring of subcutaneous adipose tissue blood flow in humans. Int J Obes Relat Metab Disord 20: 220-226, 1996.
10. Galbo H, Richter EA, Hilsted J, Holst JJ, Christensen NJ, Henriksson J. Hormonal regulation during prolonged exercise. Ann NY Acad Sci 301: 72-80, 1977.
11. Galitzky J, Sengenès C, Thalamas C, Marques M, Senard J, Lafontan M, Berlan M. The lipid-mobilizing effect of atrial natriuretic peptide is unrelated to sympathetic nervous system activation or obesity in young men. J Lipid Res 42: 536-544, 2001.
12. Hagström-Toft E, Arner P, Johansson U, Erikson L, Ungerstedt U, Bolinder J. Effect of insulin on human adipose tissue metabolism in situ. Interactions with beta-adrenoceptors. Diabetologia 35: 664-670, 1992.
13. Hansen TK. Pharmacokinetics, and acute lipolytic actions of growth hormone. Impact of age, body composition, binding proteins, and other hormones. Growth Horm IGF Res 12: 342-358, 2002.
14. Hellström L, Blaak E, Hagstrom-Toft E. Gender differences in adrenergic regulation of lipid mobilization during exercise. Int J Sports Med 17: 439-447, 1996.
15. Henderson SA, Graham HK, Mollan RA, Riddoch C, Sheridan B, Johnston H. Calcium homeostasis and exercise. Int Orthop 13: 69-73, 1989.
16. Hodgetts V, Coppack SW, Frayn KN, Hockaday TD. Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise. J Appl Physiol 71: 445-451, 1991.
17. Horowitz JF. Fatty acid mobilization from adipose tissue during exercise. Trends Endocrinol Metab 14: 386-392, 2003.
18. Jansson PA, Larsson A, Smith U, Lonnroth P. Glycerol production in subcutaneous adipose tissue in lean and obese humans. J Clin Invest 89: 1610-1617, 1992.
19. Jesek JK, Martin NB, Broeder CE, Thomas EL, Wambsgans KC, Hofman Z, Ivy JL, Wilmore JH. Changes in plasma free fatty acids and glycerols during prolonged exercise in trained and hypertensive persons taking propranolol and pindolol. Am J Cardiol 66: 1336-1341, 1990.
20. Kanaley JA, Weltman JY, Veldhuis JD, Rogol AD, Hartman ML, Weltman A. Human growth hormone response to repeated bouts of aerobic exercise. J Appl Physiol 83: 1756-1761, 1997.
21. Lafontan M, Berlan M. Characterization of physiological agonist selectivity of human fat cell alpha 2-adrenoceptors: adrenaline is the major stimulant of the alpha 2-adrenoceptors. Eur J Pharmacol 82: 107-111, 1982.
22. Lafontan M, Berlan M. Fat cell adrenergic receptors and the control of white and brown fat cell function. J Lipid Res 34: 1057-1091, 1993.
23. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
24. Moller N, Jorgensen JO, Schmitz O, Moller J, Christiansen J, Alberti KG. and Orskov H Effect of growth hormone pulse on total and forearm substrate fluxes in humans. Am J Physiol Endocrinol Metab 258: E86-E91, 1990.
25. Moller N, Schmitz O, Porksen J, Moller J, Jorgensen JO. Dose-response studies on the metabolic effects of a growth hormone pulse in humans. Metabolism 41: 172-175, 1992.
26. Moro C, Crampes F, Sengenes C, De Glisezinski I, Galitzky J, Thalamas C, Lafontan M, Berlan M. Atrial natriuretic peptide contributes to physiological control of lipid mobilization in humans. FASEB J 18: 908-910, 2004.
27. Ottosson M, Lonnroth P, Bjorntorp P, Eden S. Effects of cortisol and growth hormone on lipolysis in human adipose tissue. J Clin Endocrinol Metab 85: 799-803, 2000.
28. Samra JS, Clark ML, Humphreys SM, Macdonald IA, Matthews DR, Frayn KN. Effects of morning rise in cortisol concentration on regulation of lipolysis in subcutaneous adipose tissue. Am J Physiol Endocrinol Metab 271: E996-E1002, 1996.
29. Sengenès C, Berlan M, de Glisezinski I, Lafontan M, Galitzky J. Natriuretic peptides: a new lipolytic pathway in human adipocytes. FASEB J 14: 1345-1351, 2000.
30. Sengenès C, Bouloumié A, Hauner H, Berlan M, Busse R, Lafontan M, Galitzky J. Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes. J Biol Chem 278: 48617-48626, 2003.
31. Sengenès C, Zakaroff-Girard A, Moulin A, Berlan M, Bouloumié A, Lafontan M, Galitzky J. Natriuretic peptide-dependent lipolysis in fat cells is a primate specificity. Am J Physiol Regul Integr Comp Physiol 283: R257-R265, 2002.
32. Stich V, de Glisezinski I, Berlan M, Bulow J, Galitzky J, Harant I, Suljkovicova H, Lafontan M, Riviere D, Crampes F. Adipose tissue lipolysis is increased during a repeated bout of aerobic exercise. J Appl Physiol 88: 1277-1283, 2000.
33. 2-adrenergic receptors by epinephrine during exercise in human adipose tissue. Am J Physiol Regul Integr Comp Physiol 277: R1076-R1083, 1999.
34. 2-adrenergic receptors impairs exercise-induced lipolysis in SCAT of obese subjects. Am J Physiol Regul Integr Comp Physiol 279: R499-R504, 2000.
35. Taniguchi A, Kataoka K, Kono T, Oseko F, Okuda H, Nagata I, Imura H. Parathyroid hormone-induced lipolysis in human adipose tissue. J Lipid Res 28: 490-494, 1987.
36. Tsai KS, Lin JC, Chen CK, Cheng WC, Yang CH. Effect of exercise, and exogenous glucocorticoid on serum level of intact parathyroid hormone. Int J Sports Med 18: 583-587, 1997.
37. Wahrenberg H, Engfeldt P, Bolinder J, Arner P. Acute adaptation in adrenergic control of lipolysis during physical exercise in humans. Am J Physiol Endocrinol Metab 253: E383-E390, 1987.
38. Wijnen JA, Van Baak MA, De Haan C, Boudier HA, Tan FS, Van Bortel LM. Beta-blockade and lipolysis during endurance exercise. Eur J Clin Pharmacol 45: 101-105, 1993.